Biomedical subjects

W Kawalec

Publications and source records attributed to W Kawalec.

At least 19 recordsLinked to original sources

PubMed1996

[Vasoactive peptides, endothelin 1 and neuropeptide Y, and total peripheral vascular resistance in children with essential hypertension].

Cardiac function was evaluated in rest and after exercise on a cycloergometer in 20 patients with essential hypertension (EH) aged 14 to 19 years and 12 age-matched healthy volunteers. Selected parameters of ECHO examination and mitral flow were assessed, including SV, CO, CI, %SF, EF, LIVDd, IVSd, LVPWd, LVMI, total peripheral vascular resistance, ESS, velocity of wave E. A and E/A index. In all cases, serum ET1 and NPY levels were measured in rest and after exercise, before and after 6-month enalapril therapy. The ETI serum level in hypertensive patients did not differ from controls, while the NPY level was significantly higher in hypertensives. Exercise did not affect the ETI serum concentration, however, it did increase the NPY level. Enalapril therapy had no effect on serum peptide concentrations. Correlation of the ETI serum level with ECHO parameters, including CO, Cl, SV, LIVDd, LVPWd, %SF, TPRI and wave E velocity, as well as correlation of NPY concentration with LIVDd, LVPWd, LVMI, ESS and wave E and A velocity may suggest that these peptides influence left ventricle function and structure disturbances in children with EH.

Adolescent↗

PubMed1995

[Evaluation of the efficacy and safety of monotherapy for significant essential hypertension in adolescents with use of enalapril].

Clinical evaluation of hypotensive effectiveness and the cardiovascular and side effects of enalapril monotherapy of significant essential hypertension (SEH) in adolescents was performed. The studied group included 30 pts., aged from 12 to 18 years. The mean enalapril dose was 0.22 mg/kg/24 hours. Significant decrease of systolic, diastolic and mean arterial blood pressure was observed. ECHO examination performed after 6 months of therapy demonstrated significant decrease of intraventricular septum thickness, cardiac index and percentage of LV fractional shortening. Only a few minor side effects involving the GI tract were observed during therapy. We conclude that enalapril monotherapy is effective in adolescents with SEH and exerts a beneficial influence on sodium and purine balance and no adverse effect on the lipid profile. It can therefore be safely used in hypertensive patients with hyperuricemia and hypercholesterolemia. It causes regression of LV hypertrophy and improves exercise capacity.

Adolescent↗

PubMed1995

[Risk factors of late ventricular arrhythmias after total correction of tetralogy of Fallot in children].

The authors present an analysis of pre-, intra- and postoperative risk factors of late ventricular arrhythmias in 100 children in 5-12 years after total correction of the tetralogy of Fallot. Complex arrhythmias (III-V class according to Lown classification) were found in 19% of patients. Risk factors were: in the pre- and intraoperative period--marked endocardial fibrosis of the right ventricular outflow tract, long bypass time (> 180 min) and aortic cross-clamp (> 90 min), in the post-operative period-left ventricular dysfunction in echocardiographic examination and age > 10 years at time of the study. Complex ventricular arrhythmias were more frequent in patients with associated supraventricular arrhythmias and with progressive bundle branch block.

Arrhythmias, Cardiac↗

PubMed1994

Cardiac tumours in tuberous sclerosis: their incidence and course.

Cardiac tumours have been frequently reported in patients with tuberous sclerosis but their incidence at different ages has been evaluated in only a few studies. We performed echocardiography in 47 children with tuberous sclerosis and found tumours in 22 (47%). In none, except one newborn, did we observe any clinical symptoms of heart failure. Tumours were more frequent in children below 2 years of age (91%) than in older children. As other signs of tuberous sclerosis are often absent in infants, echocardiography may be regarded as the most useful diagnostic test at this age. Follow up studies were done in 12 children and tumour regression occurred in 6 patients.

Adolescent↗

PubMed1994