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W Kent Anger

Publications and source records attributed to W Kent Anger.

11 recordsLinked to original sources
PubMed2006

Neurobehavioral performance of adult and adolescent agricultural workers.

There are many occupational hazards associated with working in agriculture including risk of injury and exposure to pesticides. Research examining neurobehavioral effects of pesticide exposure have focused primarily on the acute effects in adults working in agriculture. Organophosphate poisoned populations have shown a consistent pattern of deficits when compared to a non-exposed or non-poisoned population on measures of motor speed and coordination, sustained attention, and information processing speed. Fewer studies have examined the effect of long-term low-level exposure on nervous system functioning in agricultural workers. Pesticides are thought to pose a considerably higher risk to children than to adults, yet little is known about the extent or magnitude of health problems related to occupational exposure to pesticides in children and adolescents. The present study compared the neurobehavioral performance of adolescents and adults working in agriculture and examined the impact of years working in agriculture on neurobehavioral performance. One hundred seventy-five Hispanic adolescent and adults completed a neurobehavioral test battery consisting of 10 computer-based tests measuring attention, response speed, coordination and memory. Age, gender, school experience, and years working in agriculture all impacted performance on the neurobehavioral tests. Comparison of adult and adolescents did not reveal decreased neurobehavioral performance in adolescents. On several tests the adolescents performed better than adult counterparts. The adolescents and adults were engaged in comparable agricultural working environments at the time of the neurobehavioral testing. These findings suggest that, at the time of exposure to pesticides, adolescents are not more vulnerable to the effects of working in agriculture. Evidence from this study suggests that cumulative exposure to low levels of pesticides over many years of agricultural work is associated with neurological impairment as measured by the Selective Attention, Symbol-Digit, Reaction Time tests. Experience handling pesticides was also associated with deficits in neurobehavioral performance.

Adolescent↗
PubMed2006

Studying health outcomes in farmworker populations exposed to pesticides.

A major goal of studying farmworkers is to better understand how their work environment, including exposure to pesticides, affects their health. Although a number of health conditions have been associated with pesticide exposure, clear linkages have yet to be made between exposure and health effects except in cases of acute pesticide exposure. In this article, we review the most common health end points that have been studied and describe the epidemiologic challenges encountered in studying these health effects of pesticides among farmworkers, including the difficulties in accessing the population and challenges associated with obtaining health end point data. The assessment of neurobehavioral health effects serves as one of the most common and best examples of an approach used to study health outcomes in farmworkers and other populations exposed to pesticides. We review the current limitations in neurobehavioral assessment and strategies to improve these analytical methods. Emerging techniques to improve our assessment of health effects associated with pesticide exposure are reviewed. These techniques, which in most cases have not been applied to farmworker populations, hold promise in our ability to study and understand the relationship between pesticide exposure and a variety of health effects in this population. Key words: biomarkers, cancer, epidemiology, health outcomes, immigrants, neurobehavioral, neuropathy, pesticides.

Agriculture↗
PubMed2004

Neurobehavioral evaluation for a community with chronic exposure to hydrogen sulfide gas.

In May 2000, the Agency for Toxic Substances and Disease Registry of the US government conducted a health investigation in response to community concerns regarding ambient and indoor hydrogen sulfide (H(2)S), odor, and health symptoms in Dakota City, Nebraska. The objective was to determine whether adult residents in an area with repeated exposure to H(2)S showed poorer performance on neurobehavioral tests than unexposed residents. Study participants were required to meet age (#10878;16 years of age) and length of residency (2 years) eligibility requirements. A battery of computer-assisted standardized neurobehavioral tests was administered in English or Spanish. A questionnaire was used to collect information about participants, demographic and health status. Three hundred forty-five people agreed to participate. After the exclusion of 10 persons, analyses were conducted on 335 participants; 171 residents in the target area and 164 residents in the comparison area. The two groups were comparable in demographic characteristics and various health conditions. Overall, neurobehavioral test results for the target and comparison groups were similar. Residence in the H(2)S-exposed area was associated with marginally poorer performance on a test of memory, namely, match to sample score, and a test of grip strength. However, these differences were not significant. Deficits in overall neurobehavioral performance were not associated with exposure to H(2)S in this study.

Adolescent↗
PubMed2004

Computer-based training for food services workers at a hospital.

INTRODUCTION: Interactive computer-based safety instruction (CBI) was given to 73 workers in the food services department of an urban hospital. RESULTS: Post-test accuracy (95%) improved significantly (p < or = 0.0001) from the pre-test (74.5 %), d = 1.09. Generalization was confirmed by increased accuracy in answering questions, posed on-the-job, that required application of knowledge to the work setting (from 46% to 79%; p < 0.0001). Problematic kitchen conditions such as puddles increased slightly after training, but adjustment for increasing production/workload revealed an overall post-training decline in problems from 0.58 to 0.32 (p = 0.0001, d = 0.89). Work practice improvement was seen in 79% of workers (p < 0.0001, d = 1.00). Effect sizes (d) of knowledge, location, and work practice improvements are large and demonstrate that the benefits of CBI extend to the workplace floor. Further, the decrease between knowledge and behavior change (d = 0.09-0.2) is less than reported following other forms of training.

Adult↗
PubMed2003

Neurobehavioral effects of exposure to trichloroethylene through a municipal water supply.

We studied a population-based sample of 143 residents of a community in which the municipal water supply had been contaminated with trichloroethylene (TCE) and related chemicals from several adjacent hazardous waste sites between 1981 and 1986. A hydraulic simulation model was used in conjunction with a geographic information system (GIS) to estimate residential water supply exposures to TCE; 80% of the participants had potential TCE exposure exceeding the maximum contaminant level (5 ppb). The Neurobehavioral Core Test Battery (NCTB), tests of visual contrast sensitivity, and the profile of mood states (POMS) were administered approximately 6 years following peak concentrations of TCE in municipal drinking water. Multivariate analysis of variance adjusted for potential confounders was used to compare mean test scores of residents classified by estimated TCE exposure (< or =5, >5-10, >10-15, >15 ppb). TCE exposure >15 ppb was associated with poorer performance on the digit symbol, contrast sensitivity C test, and contrast sensitivity D test and higher mean scores for confusion, depression, and tension. We found evidence of a strong interaction between exposure to TCE and alcohol consumption; the associations for the NCTB and POMS among persons in the high-exposure group who also consumed alcohol were stronger and were statistically significant for the Benton, digit symbol, digit span, and simple reaction time tests, as well as for confusion, depression, and tension. This study adds to the evidence that long-term exposure to low concentrations of TCE is associated with neurobehavioral deficits and demonstrates the usefulness of GIS-based modeling in exposure assessment.

Adult↗
PubMed2003

Development of the Behavioral Assessment and Research System (BARS) to detect and characterize neurotoxicity in humans.

The Behavioral Assessment and Research System (BARS) is a computer-based testing system designed to assess neurobehavioral function in humans. It was developed to provide a series or battery of neurobehavioral tests optimized for the detection of neurotoxicity in non-mainstream human populations, specifically people with limited education or literacy. Key to meeting this goal were simply-stated instructions divided into an elemental series of steps, a 9BUTTON response unit to replace the computer keyboard for responding, and spoken instructions. Modifications all underwent serial testing in target populations to successively hone the changes to be more effective. A similar process was followed when developing adjustable parameters, test reliability assessments, and when implementing these tests with populations from different cultural groups and children. The principles and experiences that guided the development of BARS should inform the development of future testing systems to ensure that the new tests can be used with non-mainstream populations, which may be increasingly subject to neurotoxic exposures.

Adolescent↗
PubMed2003

Measures of short-term test-retest reliability of computerized neurobehavioral tests.

Neurobehavioral test batteries are often administered repeatedly to evaluate changes over time or effects of clinical interventions or neurotoxic exposures. Time intervals between test sessions range from very short (hours) to very long (decades). The aim of this study was to compare the impact of two brief time intervals on the test-retest reliability of frequently used neurobehavioral tests. Fifty healthy adults were recruited through newspaper advertisements in Portland, Oregon. Participants were divided into either a 6h (same-day) or 1-week retest group. All participants completed a battery of tests from the computerized Behavioral Assessment and Research System (BARS). Reliability was assessed by Pearson product-moment correlation and by intraclass correlation coefficient (ICC). The test battery generally showed adequate reliability in the short-term (week) and very short-term (day) and stability in performance over repeated administration when examined by multiple measures. Intraclass correlation coefficient ranged from 0.35 to 0.85. The magnitude of variation of performance in the administered tests was equally distributed around zero (i.e. no difference). The findings suggest that neurobehavioral tests such as BARS may be a useful tool for the assessment of acute exposures and clinical status where short-term evaluation is required (e.g. in the same-day or within 1 week).

Adult↗
PubMed2003

Neurobehavioral performance and work experience in Florida farmworkers.

Farmworkers experience many work-related hazards, including exposure to neurotoxicants. We compared neurobehavioral performance of 288 farmworkers in central Florida who had done farm work for at least 1 month with 51 controls who had not. Most of the farmworkers had worked in one or more of three types of agriculture: ornamental ferns, nurseries, or citrus fruit. We collected information on farm work history in a structured interview and evaluated neurobehavioral performance using a battery of eight tests. Analyses were adjusted for established confounders including age, sex, education, and acculturation. Ever having done farm work was associated with poor performance on four tests--digit span [odds ratio (OR) = 1.90; 95% confidence interval (CI), 1.02-3.53], tapping (coefficient = 4.13; 95% CI, 0.00-8.27), Santa Ana test (coefficient = 1.34; 95% CI, 0.29-2.39), and postural sway (coefficient = 4.74; 95% CI, -2.20 to 11.7)--but had little effect on four others: symbol digit latency, vibrotactile threshold, visual contrast sensitivity, and grip strength. Associations with farm work were similar in magnitude to associations with personal characteristics such as age and sex. Longer duration of farm work was associated with worse performance. Associations with fern work were more consistent than associations with nursery or citrus work. Deficits related to the duration of work experience were seen in former as well as current farmworkers, and decreased performance was related to chronic exposure even in the absence of a history of pesticide poisoning. We conclude that long-term experience of farm work is associated with measurable deficits in cognitive and psychomotor function.

Adult↗
PubMed2002

Interactive training versus reading to teach respiratory protection.

A tenet of behavioral education is that interactive training produces superior retention compared with reading. However, this has not often been directly tested and never with practical occupational information in working adults. Adults from diverse occupational backgrounds learned the principles of proper respiratory protection presented (a) in a book, (b) on a computer monitor, (c) through interactive computerized training consisting of textual information and illustrative pictures followed by quizzes and feedback, or (d) passively viewing the information and quizzes in Condition c on a computer monitor. Interactive training produced significantly more correct test answers at immediate posttraining, 1 week, and 2 months. This study demonstrated the superiority of interactive training for teaching occupational safety and health information in working adults.

Adult↗
PubMedDate not supplied

Transferring behavioral technology across applications.

Application flows naturally from good science, and behavioral toxicology is no exception. Phenomena discovered and procedures developed in behavioral laboratories are being applied on a wide scale in commercial, industrial, and governmental settings. In behavioral toxicology, this transfer of technology has occurred in an ad hoc manner, albeit with a degree of sophistication. The development of technology transfer in other disciplines is instructive. A symposium at the May 2001 meeting of the Behavioral Toxicology Society examined this issue, and some participants provide their contributions here. Henry Pennypacker examines the issue of whether behavioral procedures can meet the demanding standards required to transfer technology to commercial endeavors and concludes that, under some conditions, they can. He notes that the shortage of well-developed and transferred behavioral technologies results from a lack of understanding of the process of technology transfer on the part of behavior analysts. In the field of engineering, the results of basic research are transformed to candidate technologies that meet standardized criteria with respect to three properties: quantification, repetition, and verification. Kent Anger describes the challenging steps in the trail from the laboratory to wide-scale application-steps that are essential for the scaling up of any behavioral technique. Finally, Paul Mele describes the legal background to patenting and copyrighting ideas, a process that behaviorists have rarely used. Together, these topics identify the requirements and warn of the challenges and intricacies that await those who seek to transfer behavioral technology beyond the laboratory.

Animals↗