PubMed Health⌕ Search

Biomedical subjects

W Kotte

Publications and source records attributed to W Kotte.

At least 19 recordsLinked to original sources
PubMed1990

[Capillary resistance in premature and newborn infants and its relation to hemostatic potential].

Capillary resistance, platelet count, platelet adhesiveness and aggregation and thrombelastogramm (TEG) were studied in 40 healthy newborn infants (term eutrophic, preterm eutrophic and hypotropic). The capillary resistance was normal in all cases. The physiologic decrease of platelet aggregation in newborns and the prolonged clotting time in TEG (hypotrophic infants) were without influence on the capillary resistance. An important factor of the normal capillary resistance in newborns is normal platelet adhesiveness.

Fetal Growth Retardation↗
PubMed1987

Improved treatment results in childhood acute nonlymphoblastic leukemia with the BFM-AML protocol 78 in a multicenter study in the GDR.

Eighty-seven children with acute nonlymphoblastic leukemia were treated with the AML protocol BFM 78 between June 1979 and February 1986 in a multicenter study in the GDR. Seventeen children (20%) died from early complications, eight did not respond to therapy. Fifty-eight patients (70%) achieved a complete remission. Twenty-three patients relapsed. The life table analysis revealed after 5 years a probability for event-free survival of 36% (SD = 6%) and an event-free interval of 51% (SD = 8%). Six patients were transplanted in first remission. Two of them died; one (M 1) on day + 19 from encephalopathy and one (M 4) on day + 60 from acute GVHD. The overall results are in good correlation with the original BFM study, but there are differences in the subtypes. Results are superior to other AML protocols in our group.

Actuarial Analysis↗
PubMed1983

[Drug effect on the rotation thromboelastogram in newborn infants].

The impact of the antibiotics carbenicilin and gentamycin on the aggregation and adhesiveness of thrombocytes and on the rotation thrombelastogramme is investigated in healthy newborns. Thrombocyte aggregation was markedly inhibited by carbenicilline; gentamycine had no influence. Thrombocyte adhesiveness was less influenced by both medicaments. The parameters of TEG, viz. reaction time, clotforming time, thrombus elasticity and index were compared before and after rotation and with and without medicaments. Under carbenicilline a prolongation of the clotforming time and a decrease of thrombus elasticity could be shown to exist after rotation. The impact of medicaments on the rotation thrombelastogramme can only be conceived by comparing the values before and after rotation in each case with and without medicament and not simply evaluating it, so that the rotation thrombelastogramms cannot be recommended to be used for assessing the disturbance of thrombocyte function induced by medicaments.

Azlocillin↗