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Biomedical subjects

W Królikowski

Publications and source records attributed to W Królikowski.

At least 19 recordsLinked to original sources
PubMed2001

[Intraalveolar hemorrhage as a cause of acute respiratory failure in catastrophic antiphospholipid syndrome].

We report the case of a catastrophic antiphospholipid syndrome (CAPS), which developed without a known cause in a 38-year old man. Primary antiphospholipid syndrome was diagnosed one year earlier. Clinical manifestations of CAPS were dominated by diffuse intraalveolar haemorrhage leading to acute respiratory failure and renal failure. Syndrome of multiorgan failure developed despite the treatment with plasmapheresis, high doses of glycocorticosteroids, an intravenous gammaglobulins. The patient died 6 weeks after the admission.

Adult↗
PubMed2000

Solitons in nonlocal nonlinear media: exact solutions.

We investigate the propagation of one-dimensional bright and dark spatial solitons in a nonlocal Kerr-like media, in which the nonlocality is of general form. We find an exact analytical solution to the nonlinear propagation equation in the case of weak nonlocality. We study the properties of these solitons and show their stability.

Journal Article↗
PubMed1999

Partially coherent solitons of variable shape in a slow Kerr-like medium: exact solutions.

We carry out a theoretical investigation of the properties of partially coherent solitons for media which have a slow Kerr-like nonlinearity. We find exact solutions of the Nth-order Manakov equations in a general form. These describe partially coherent solitons (PCSs) and their collisions. In fact, the exact solutions allow us to analyze important properties of PCSs such as stationary profiles of the spatial beams and effects resulting from their collisions. In particular, we find, analytically, the number of parameters that control the soliton shape. We present profiles which are symmetric as well as those which are asymmetric. We also find that collisions allow the profiles to remain stationary but cause their shapes to change.

Journal Article↗
PubMed1999

Asymmetric partially coherent solitons in saturable nonlinear media.

We investigate theoretically properties of partially coherent solitons in optical nonlinear media with slow saturable nonlinearity. We have found numerically that such a medium can support spatial solitons which are asymmetric in shape and are composed of only a finite number of modes associated with the self-induced waveguide. It is shown that these asymmetric spatial solitons can propagate many diffraction lengths without changes, but that collisions change their shape and may split them apart.

Journal Article↗
PubMed1999

Dynamics of formation and interaction of photorefractive screening solitons.

An experimental and numerical investigation of the dynamical, time-dependent effects accompanying the formation and interaction of two-dimensional spatial screening solitons in a photorefractive strontium barium niobate crystal is performed. These effects include initial diffraction, collapse to the soliton shape, the oscillation of beam diameters, beam bending, and the rotation, twisting, and turning of soliton pairs. The dynamics of complex spiraling of two incoherent solitons is considered in more detail.

Journal Article↗
PubMed1994

Thrombinogenesis and its pharmacological modulation in atherosclerosis.

Appearance of thrombin in circulating blood can be monitored in the clinical setting by measuring specific thrombin markers, such as fibrinopeptide A, thrombin-antithrombin III or prothrombin fragment 1 + 2. In myocardial infarction monitoring of thrombin activity is of growing clinical interest. High levels of thrombin markers indicate an increased risk to a patient with myocardial infarction. Persistent, high thrombin marker levels, despite heparin anticoagulation, point to ongoing thrombin generation that may necessitate more anticoagulation, increased antiplatelet treatment, angioplasty or, in the future, use of new antithrombotic drugs. Recently, new sensitive methods have been developed to study the reaction of thrombin generation in clotting blood. These methods permitted to demonstrate that, aspirin, contrary to several other antiplatelet drugs, delay the process of thrombin formation. Continuous dampening of thrombin formation by aspirin might be one of the mechanisms responsible for its prophylactic and therapeutic efficacy. Hypercholesterolemic subjects might profit less than others from this type of treatment, since aspirin dampening effects are not so evident in hypercholesterolemia.

Animals↗
PubMed1991

[Treatment of respiratory tract infections with pefloxacin].

Pefloxacin, a 4-quinolone derivative, was administered in the dose of 800-1200 mg for the mean of 12 days to 24 patients with respiratory tract infection complicating chronic bronchial asthma or chronic obstructive lung disease. Patients with positive sputum culture and bacteria sensitive to pefloxacin were included in the study. Total eradication of the offending microorganisms was achieved in 54% of patients, and partial--in the next 20%. A poor efficacy of pefloxacin against Streptococcus species has been confirmed. In a few cases we have observed the development of resistance of isolated bacteria to pefloxacin during the course of treatment.

Adult↗
PubMed1985

Prostacyclin for ischemic ulcers in peripheral arterial disease. A random assignment, placebo controlled study.

A 72 h infusion of prostacyclin or placebo was given into femoral artery as a treatment for ischemic ulcers in 30 patients with peripheral arterial disease. Patients were well matched for age, sex, type and localization of disease, rest pain, number and area of ulcers, calf blood flow and previous sympathectomies. They had no diabetes mellitus, gangrene or marked aorto-iliac involvement. Six weeks after the infusion there was a significant difference in ulcer area between the two groups (p less than 0.02, t unpaired test): mean ulcer area decreased (p less than 0.02, t paired test) in the prostacyclin-treated group, but not in the placebo group (p greater than 0.05, t paired test). Thus, intra-arterial infusion of prostacyclin promotes healing of ischemic ulcers in non-diabetic patients with peripheral arterial disease without gangrene.

Adult↗
PubMed1984

Treatment with prostacyclin of various forms of spontaneous angina pectoris not responding to placebo.

We studied the effects of prostacyclin on the frequency, duration and severity of ischemic attacks in spontaneous angina. Twenty-seven patients who did not respond to 48 hours infusion of placebo, received after a two-day observation period, 48 hours infusion of prostacyclin at an average rate of 4.0 ng/kg/min. Prostacyclin decreased number of ischemic attacks in only one of four patients with Prinzmetal angina, and was without any effect in five other patients whose attacks were associated with increase in blood pressure and heart rate. However, in 12 of 18 patients with coronary atherosclerosis, whose attacks were characterized by ST-segment depression without increase in heart rate or blood pressure, and often occurred at night, prostacyclin consistently diminished both frequency of anginal attacks and nitroglycerin consumption. This improvement lasted from 10 days to 3 months. Healing of endothelial damage by prostacyclin could explain the favorable therapeutic response in this subset of patients with spontaneous angina.

Adult↗