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Biomedical subjects

W Kurz

Publications and source records attributed to W Kurz.

At least 19 recordsLinked to original sources
PubMed1991

[Treatment of Monteggia fracture in children].

Described in this paper is a therapeutic concept by which to cope with Monteggia's fracture in childhood. It is based on experience obtained from 72 cases with injuries of that kind and their evaluation in a group study. Therapeutic approach to the individual case was determined by the following criteria: age of infant, localisation and shape of ulnar fracture, reducibility of capitulum radii, and accompanying injuries requiring treatment on the same arm. The need for surgical stabilisation of ulnar fracture was found to increase along with growing age of the affected child. High-stability anatomic reduction of the ulnar fracture proved to be a prerequisite for safe stabilisation of the radial capitulum. Close reduction has proved to be sufficient in many instances. Open reduction and internal fixation were found to be necessary in cases in which an ulnar fracture was irreducible or instable and/or a radial head was not reducible. Minimal osteosynthesis and plaster cast is considered to be an optional therapy for younger children, whereas ulnar stabilisation by means of plates is preferred for children in somewhat advanced age of childhood. The radial head may be fixed by trans-articular Kirschner's wire (WITT) or primary reconstruction of the annular ligament, using a strip of biceps or triceps tendon, or adaptation around the collum radii and ulna of the proximal radio-ulnar joint by means of a sling of Dexon or Vicryl suture.

Child↗
PubMed1990

[Evaluation of preoperative admission and anesthesia consultation in surgery].

Preoperative consultation with patients on their imminent hospitalisation for surgery and on aspects of necessary anaesthesia was introduced at the Lübben District Hospital for planned operations in 1977. Five categories of diseases which required general surgery have now been evaluated, in this context. That consultation, based on outpatient practice, has proved helpful in reducing the time of hospitalisation, disability, and pre-admission waiting periods. Surgical and bed capacities were more effectively utilised, and duplicated examinations were avoided. Patients were given a say in surgical timing.

Cholecystectomy↗
PubMed1988

[The femoral neck fracture in childhood].

A retrospective study into fracture of the femoral neck in childhood was compiled from 18 hospitals by the Working Group on Paediatric Traumatology, since conditions of that kind were found to be very rare. Thirty-eight fractures were kept under observation, with follow-up checks being made on 29 of them. An account is first given of peculiarities of the proximal femur in childhood. Results are communicated, and therapeutic approaches are compared. A therapeutic proposal has been derived from these findings as well as from literature data.

Child↗
PubMed1988

[Traumatic hip dislocation in childhood].

Twelve children with hip dislocation were recorded from 18 hospitals of the GDR in a collective study conducted on behalf of the Working Group on Paediatric Traumatology. The closed approach was exclusively taken to all reductions, and all of them were performed within the twelve-hour limit. Avascular necrosis of the femoral head or other growth disorders were not observed. Relief periods were conspicuously differentiated, which gave rise to the proposal of unitisation of the therapeutic approach.

Adolescent↗
PubMed1988

[Physical therapy within the scope of fracture treatment in children. Recommendations of the Traumatology in Childhood Study Group].

Physiotherapeutic follow-up treatment is required only in exceptional cases of fractures in childhood. Physiotherapeutic indications are justified for fractures with months of immobilisation, multiple fractures, fractures accompanied by soft-tissue defects and nerve injuries, vertebral fractures, fractures and craniocerebral trauma, and fractures entailing the risk of bone necrosis. Passive exercises are not at all indicated.

Child↗
PubMed1986

Isolation and characterization of a tupaia rhabdovirus.

Liver tumor biopsies of a 9-year-old moribund Tupaia (tree shrew) were explanted and cultured in vitro. The cell cultures degenerated spontaneously. A virus was isolated from the cell-free supernatant of these cultures and subsequent electron microscopy revealed rhabdovirus-like particles. Negative staining showed typical bullet-shaped particles 125-220 nm in length with a diameter of 68 nm studded with a dense layer of surface projections 9-11 nm in length. One end of the virion was flat, the other end was open; a distinct ribonucleoprotein (RNP) core was visible. The pitch of the RNP was 4.5 nm. Virus was assembled and matured by budding primarily into regions of dilated endoplasmic reticulum. The dimensions of the virion also were determined in ultrathin sections: the diameter and length of the virion were 52 and 125-255 nm, respectively, those of the RNP core were 39 and 120-240 nm. Only tupaia embryonic fibroblasts and kidney cells were susceptible to the rhabdovirus. The virus, when plaque-assayed on tupaia embryonic fibroblasts, grew to a titer of 1 X 10(6) PFU.

Animals↗
PubMed1984

Identification of 17 beta-estradiol as the estrogenic substance in Saccharomyces cerevisiae.

Saccharomyces cerevisiae possesses a high-affinity estrogen binding protein and an endogenous ligand that displaces [3H]estradiol from both the yeast binding protein and mammalian estrogen receptors. Semipurified preparations of this ligand have been shown to exhibit estrogenic activity in mammalian systems. We now describe the purification procedure and ultimate identification of the estrogenic substance in extracts of S. cerevisiae as 17 beta-estradiol. Organic solvent extracts of commercially obtained dried yeast were sequentially chromatographed on silica gel columns and then subjected to a series of reversed phase HPLC fractionations. Active ligand was monitored by [3H]estradiol displacement in a rat uterine cytosol assay. After seven chromatography steps, the purified and highly active ligand exhibited a single peak with retention times identical to those of 17 beta-estradiol on both HPLC and GC. The yeast material was identified as 17 beta-estradiol by its UV absorbance and mass spectrometric fragmentation pattern. In addition, radioimmunoassay confirmed the presence of approximately the same mass of 17 beta-estradiol (approximately equal to 800 ng/1.5 kg of yeast) as estimated both by a competitive binding assay with estrogen receptor and by mass spectrometry. Extraneous contamination by estradiol was excluded by repeat experiments with different batches of starting material and demonstration of estradiol by RIA in conditioned medium and cell pellets of laboratory-grown S. cerevisiae whereas non-conditioned medium did not possess the steroid. We conclude that 17 beta-estradiol is a yeast product.

Estradiol↗
PubMed1984

[Tarsal fractures in childhood].

The treatment of tarsal fractures in children was analysed in a joint research project performed in eight GDR surgical clinics of various size. 63 fractures of the tarsal bones were treated over a seven-years period. Each single bone of the tarsus was analysed separately. For reasons of comparison, however, the results were evaluated of all tarsal fractures in the follow-up in connection with Seyfarth's classification as applied with respect to calcaneal fractures. The findings show that tarsal fractures in children can be thoroughly cured by conservative treatment. Operative treatment is indicated only in few cases.

Calcaneus↗
PubMed1982

Intertypic superinfection of herpes simplex virus in vivo leads to reisolation of latent viruses with newly acquired lymphotropic properties.

The susceptibility of juvenile Tupaias to several strains of temperature-sensitive mutants of HSV-1 and 2 was tested. It was found that in all cases the animal survived an infection of 1 X 10(7) PFU of temperature-sensitive mutants which were administered intravenously. In contrast, an infection dose of 1 X 10(3) PFU of wild-type HSV-2 and 1 X 10(2) PFU or HSV-1 was fatal for juvenile Tupaias. Those animals which had initially been infected with the ts-mutants of HSV-1 and/or 2 were protected against a superinfection of a lethal dose of HSV-1 or HSV-2. The state of HSV latency in surviving animals was investigated. The infectious virus was recovered from the spinal cords of those animals which had been initially infected with wild-type HSV-1 or 2 and/or superinfected with HSV-1 or 2. In contrast, the infectious viruses were recovered only from the spleens of those animals which had initially been infected with ts-mutants of HSV-2 and superinfected with HSV-1. These recovered viruses were plaque-purified and analysed in detail. It was found, firstly, that recovered viruses from the spleens of Tupaias lost their pathogenicity and tropism in Tupaias. Secondly, significant changes in the genome of the recovered viruses from the spleen of Tupaias were detected. The results indicate that an intertypic interaction between HSV-1 and 2 occurred in vivo which is responsible for the observed change in organotropism and pathogenicity of the recovered viruses.

Animals↗
PubMed1981

Effect of manual lymphdrainage massage on blood components and urinary neurohormones in chronic lymphedema.

In an earlier paper we have shown that manual lymph drainage massage of edematous limbs can result in the excretion of up to 1 liter urine derived from reabsorption and transport from the interstitial fluid, simultaneously with significant changes in the excretion of urinary neurohormones. These findings indicated that histamine and serotonin were released from the edematous tissue and that circulation improved through increased output of adrenaline and noradrenaline. The results achieved led us to assume that similar changes may have occurred in the blood during treatment, and induced us to study the effect of manual lymphdrainage on various blood constituents and urinary neurohormones.

Adolescent↗
PubMed1981

[Injuries to the epiphyseal groove and bone growth].

Lesions of the epiphyseal cartilage of the growing bone lead to disturbances of growth. Experiments in the proximal epiphyseal cartilage of the rabbit tibia was carried out as an instruction about the disturbances of growth after Küntscher-nailing. The injured plane of the epiphyseal cartilage amounted to 2%. The disturbances of growth were analysed in dependence on the produced diaphysis fracture and the placement period of the osteosynthetic material. Functionally significant disturbances of growth are not caused after the lesion of the epiphyseal cartilage less than 2% of its plane and removal of the metal after the consolidation of the fracture.

Animals↗
PubMed1979

[Tibial fractures in children (author's transl)].

In a collective study of 22 surgical clinics 1235 closed diaphyseal tibial fractures in children from 0 to 14 years were analysed. The incidence of this type of fracture in relation to all fractures in childhood, was 6.2%. In pre-school children isolated tibial fractures and incomplete fractures predominated, while in children from 6 to 14 years tibial plus fibular fractures as well as displaced fractures occurred more frequently. Closed reduction and plaster cast were used as standard treatment. Traction was used only exceptionally. In only 3.0% osteosynthesis was performed under the following indications: irreducible fracture, multiple fractures, concomitant chest or abdominal injury, polytrauma.

Adolescent↗