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Biomedical subjects

W L Annable

Publications and source records attributed to W L Annable.

10 recordsLinked to original sources
PubMed1989

Endophthalmitis due to Propionibacterium acnes sequestered between IOL optic and posterior capsule.

A 68-year-old woman had delayed onset, persistent uveitis following routine extracapsular cataract extraction with posterior chamber intraocular lens implantation. The patient initially responded to topical steroids, but developed a whitish capsular plaque through to represent possible Propionibacterium acnes endophthalmitis. A vitrectomy and capsular biopsy yielded cultures positive for P. acnes only after nine days. The intraocular lens was left in place. Light and electron microscopy revealed bacteria sequestered within the capsular bag.

Aged↗
PubMed1987

Pigmented corneal rings in neonates with liver disease.

We performed eye examinations in neonates to determine whether pigmented corneal rings were present in infants with hepatic disease, as in adults. None of 16 control infants had pigmented corneal rings, but 10 (71%) of 14 infants with cholestatic liver disease had such rings. Most rings could be seen without slit lamp by direct inspection of the cornea. Furthermore, the rings appeared to resolve over time. Liver dysfunction tended to be more severe in patients with corneal rings. We speculate that abnormal tissue accumulation of copper may be present in many infants with cholestatic liver disease. Ophthalmologic examination for pigmented corneal rings or determination of serum copper levels may need to be performed in patients at high risk with hepatic disease to monitor for excessive copper accumulation.

Copper↗
PubMed1984

Torulopsis glabrata sepsis appearing as necrotizing enterocolitis and endophthalmitis.

Torulopsis glabrata causes an increasingly frequent infection in immunocompromised adults. In a 1,910-g, 36-week, small-for-gestational-age neonate, T glabrata caused necrotizing enterocolitis and endophthalmitis. The fungus was not grown from cultures obtained from four blood specimens but was seen microscopically in methenamine silver-stained sections of resected bowel.

Candida↗
PubMed1983

Hypertensive retinopathy in the newborn infant.

Hypertension (blood pressure greater than 70 mm Hg on three days) was noted in 1.2% of all neonatal admissions to the intensive and intermediate care nurseries. During this investigation of neonatal hypertension, a retinopathy identical to that seen in hypertensive adults was noted. Indirect ophthalmoscopy was performed in 21 neonates with elevated blood pressure. Eleven of these patients demonstrated some or all of the following abnormalities: increased ratio of venous to arterial caliber, vascular tortuosity (including arteriovenous crossing changes), superficial and deep hemorrhages, and exudates. These findings appeared to resolve after control of the hypertension. The specificity of this constellation of lesions for hypertensive retinopathy and their possible clinical significance are explained in light of what is known about hypertensive retinopathy in adults.

Exudates and Transudates↗
PubMed1981

Candida endophthalmitis in the premature infant.

An attempt was made to determine the incidence and natural history of Candida endophthalmitis in the premature infant with systemic candidiasis. Each of eight premature infants were examined by indirect ophthalmoscopy within one week of their diagnosis. At this stage, four infants had multiple fluffy white lesions on both the retina and the vitreous, together with a diffuse vitreous haze. Three of the infants had interlesional and lesional-retinal vitreous strands. Three infants treated with amphotericin B and 5-fluorocytosine showed gradual disappearance of the lesions. The fourth infant died early in the course of antifungal therapy, when the eye lesions were progressing. Candida sepsis was particularly prevalent in the very low-birth-weight infant with a prolonged hospital course and treated with multiple broad-spectrum antibiotics. The course of the eye lesions indicates a good prognosis for Candida endophthalmitis, although further follow-up is necessary.

Amphotericin B↗
PubMed1977

Intraocular lens surgery on a resident's service.

Twenty-three patients had intraocular lens surgery performed by eight separate ophthalmology residents over an eighteen month period of time. Adequate technical results were achieved in 19 of the 23 cases. Three patients had visual complications directly related to the intraocular lens surgery: two with bullous keratopathy and one with cystoid macular edema. By restricting surgical indications to older patients with good vision in the fellow eye and using general anesthesia in conjunction with the operating microscope, osmotic agents, intracapsular surgery, and close operative supervision, it is hoped that results will justify continued use of intraocular lenses on our resident's service.

Aged↗
PubMedDate not supplied

Long-term follow-up of Candida endophthalmitis in the premature infant.

In the March 1981 issue of the Journal of Pediatrics, Baley, Annable and Kleigman discussed the natural course of Candida endophthalmitis in the premature infant. We now have long-term follow-up on the three surviving infants along with follow-up on an additional eight patients. Though vitrectomy is routinely performed in adults, we recommended that it not be performed in premature infants with systemic candidiasis and associated vitreo-retinal pathology. These 11 infants with candidal endophthalmitis secondary to systemic candidiasis demonstrated minimal residual ocular pathology after having been treated with systemic antifungals alone. Neither vitreous taps nor intravitreal injections should be performed in infants with ocular candidiasis.

Amphotericin B↗
PubMedDate not supplied

Iritis in children with varicella.

A prospective study that included 82 consecutive children seen over 2 years by five pediatricians was undertaken to determine the incidence of iritis in children with chickenpox. Twenty-one (25%) children without pox on their lids were found to have iritis. Follow-up of children with objective evidence of iritis revealed no long-term sequelae.

Adolescent↗