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Biomedical subjects

W L Becker

Publications and source records attributed to W L Becker.

6 recordsLinked to original sources

Migraine-associated symptoms: clinical significance and management.

Nausea is common in patients with migraine. A number of antiemetic drugs can be useful in migraine treatment, and those with a prokinetic action (metoclopramide and domperidone) may also improve gastrointestinal absorption of analgesics and triptans during a migraine attack. In addition to providing headache relief, the triptans are very effective in relieving migraine-associated nausea. For migraine patients with nausea and/or vomiting severe enough to interfere with the use of oral medications, alternative drug delivery methods can be used. These include the injectable, intranasal and rectal suppository routes, and specialized oral medications such as sublingual tablets and oral wafers that dissolve in the mouth. Fortunately, effective medications that use some of these alternative delivery routes have become more available over the past several years.

Humans↗

Normal eyelid crease position in children.

Proportions of the upper lid were determined based on the following measurements in 33 children: lash-line-lid crease (LC), lashline-lower brow (LB), vertical fissure, and horizontal fissure. Age-matched mean measurements (mean LC/LB ratio = 0.33) for 26 white vs 7 black children, and for 16 males vs 17 females were not significantly different. However, the mean ratio in 15 preschool and school-age children was significantly greater than that in 18 infants and toddlers (less than 4 years old) (P < .01). We conclude that the normal eyelid crease position in children is one third up the lashline to the lower brow. However, the normal eyelid crease position in infants and toddlers is slightly less than, and, in older preschool and school-age children, slightly greater than this distance up the lashline. Thus, age may determine the surgical placement of the eyelid crease in children with indistinct creases.

Adolescent↗

Glaucoma visual field analysis by computed profile of nerve fiber function in optic disc sectors.

Automated perimetry has decreased the subjective aspects of data collection, but analysis has remained largely subjective. A microcomputer permits more objective analysis by regrouping and averaging data points in the threshold static visual field according to their retinotopic projection onto the optic disc rather than according to their eccentricity from the point of fixation. The applications of the technique include (1) following glaucomatous visual field loss, (2) differentiating glaucomatous from other forms of visual loss, and (3) studying the effects of aging on the visual field. Six formulas for data analysis are described, and their relative usefulness discussed. Percent loss or gain seemed to convey the most diagnostic information to the clinician. Percent of expected sensitivity was less than the decimal visual acuity when the diagnosis was glaucoma but greater when the diagnosis was cataract. In some cases this analytic method should provide information that could favorably affect patient management.

Adolescent↗