Biomedical subjects

W L DONOHUE

Publications and source records attributed to W L DONOHUE.

At least 19 recordsLinked to original sources

PubMed1964

SUBACUTE INCLUSION ENCEPHALITIS: A CLINICAL AND PATHOLOGICAL REVIEW.

Subacute inclusion encephalitis has been reported most frequently from Western Europe; only 16 cases have been described in North America. During the past eight years the authors have encountered 14 cases in the Toronto area, and histological confirmation has been obtained in seven of these.The disease most often presents as a combination of progressive personality and intellectual deterioration combined with myoclonic seizures or drop attacks and focal neurological deficits, although extrapyramidal symptoms or evidence of raised intracranial pressure may also occur.At the time of the initial presentation the EEG was characteristic in only nine of the 14 cases, but a first-zone rise in the colloidal gold curve was present in all cases in which it was carried out.From the pathological features of the disease, as described, and its absence of familial occurrence, it is concluded that a viral origin is most probable, although its rarity and predilection for a particular age group are unusual.

Canada↗

PubMed1964

EFFECT OF ABO INCOMPATIBILITY ON PREGNANCY-INDUCED RH ISOIMMUNIZATION.

The protective effect of ABO incompatibility between mother and fetus in respect of pregnancy-induced Rh isoimmunization has been recognized for approximately 20 years. Many have tacitly assumed that this protection was absolute and that when an infant was born with Rh hemolytic disease of the newborn, who was also ABO-incompatible with its mother, there must have been a previous ABO-compatible pregnancy in which the mother was initially sensitized. It has also been assumed that pregnancy-induced Rh isoimmunization could not occur if the father was AB and the mother O. Data are presented to show that both of these assumptions are not universally true. In a detailed study of a large number of families with pregnancy-induced Rh iso-immunization, nine families were found in which sensitization occurred and in which ABO incompatibility was present in every pregnancy. In addition, three families are documented in which pregnancy-induced Rh immunization had occurred and in which the father was AB and the mother O.

ABO Blood-Group System↗

PubMed1963

LIGHT AND ELECTRON MICROSCOPIC STUDIES OF "MYOGRANULES" IN A CHILD WITH HYPOTONIA AND MUSCLE WEAKNESS.

Examination by light and electron microscopy of more than 100 muscle biopsies revealed one very unusual case. A 4-year-old boy with non-progressive muscle weakness and hypotonia was found to have small particles, termed "myogranules", in many muscle fibres from two gastrocnemius biopsies. Paraffin sections and thin sections of plastic-embedded muscle showed that the rod-shaped myogranules measured between 0.1 and 5 microns in length, and were usually orientated in the long axis of the fibre. Normal cross-striations could not be seen in areas occupied by myogranules, although adjacent parts of the same fibre were normal. Electron micrographs showed myofilaments running through the myogranules and a periodicity similar to sections of recrystallized muscle protein paramyosin. It is possible that this child has a disturbance of muscle proteins.

Actin Cytoskeleton↗

PubMed1962