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Biomedical subjects

W L Fritz

Publications and source records attributed to W L Fritz.

7 recordsLinked to original sources

Fluorescein blue, light-assisted capsulorhexis for mature or hypermature cataract.

This technique is for use in eyes with mature or hypermature cataract resulting in lack of fundus reflex during capsulorhexis. Fluorescein staining is performed before the capsulorhexis is made. A blue filter in the coaxial light accentuates the remaining rim of bright blue fluorescence and aids in exact formation of the anterior opening. Seven eyes with a postoperative visual acuity of light perception had surgery using this technique. Visual acuity ranged from 20/200 to 20/20 up to 3 months postoperatively. No untoward reaction to the fluorescein was observed; however, the long ultrasound exposure for very hard nuclei (up to 4 minutes) caused corneal edema in two eyes. This technique is regularly used in all eyes with insufficient fundus reflex caused by lens opacity or vitreous disease.

Capsulorhexis↗

Kinetics of theophylline; variability and effect of arterial pH in chronic obstructive lung disease.

The pharmacokinetic behavior of theophylline was determined in 12 patients during an acute exacerbation of their chronic obstructive pulmonary disease. A 5.6 mg/kg loading dose of aminophylilne was administered, followed three hours later by a 0.9 mg/kg/hr continuous infusion. The loading dose increased the serum theophylline level an average of only 5.77 microgram/ml. After the loading dose, only five patients had levels greater than 10 microgram/ml. Mean initial drug clearance was 0.77 L/kg/hr, half-life 9.1 hr, and apparent volume of drug distribution .887 L/kg. Wide inter- and intrapatient pharmacokinetic variability was observed. The variability of drug distribution was inversely correlated with the arterial pH. These patients with chronic obstructive pulmonary disease appeared to require more theophylline when acidemic than when alkalemic to achieve similar serum theophylline concentrations.

Aged↗