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Biomedical subjects

W L Hanson

Publications and source records attributed to W L Hanson.

At least 73 records · Page 4Linked to original sources
PubMed1983

Changes in acid phosphatase activity during sporulation of Eimeria tenella oocysts.

Extracts of sporulated oocysts of Eimeria tenella have acid phosphatase activity which can be separated into Peak I (basic form) and Peak II (acidic form) on a DEAE-Sepharose Column. 2. Sporulation markedly effects the behavior of Peak I acid phosphatase (basic form) through the DEAE-Sepharose Column. 3. The Km value of Peak I decreases during sporulation. 4. The data obtained suggest that during sporulation the basic form of acid phosphatase (Peak I) undergoes marked degradation and transformation indicating that acid phosphatases may play an important role in the metabolism of E. tenella.

Acid Phosphatase↗
PubMed1982

alpha-Difluoromethylornithine: a promising lead for preventive chemotherapy for coccidiosis.

alpha-Difluoromethylornithine (DFMO; RMI 71,782) given in drinking water in concentrations as low as 0.0625% inhibited infections of Eimeria tenella and minimized the development of lesions in chickens. It had approximately the same activity as a currently used anticoccidial drug, amprolium, and also had the advantage of being relatively nontoxic in chickens. Body weight gains were not reduced in chickens given 0.0635% DFMO or less for 14 days starting 8 days before they were inoculated with oocysts, but were reduced in chickens given drinking water containing 0.125 and 0.25% DFMO. The anticoccidial activity of DFMO was completely reversed by injection (intraabdominal) of putrescine hydrochloride (300 mg/kg of body weight/day), indicating that the drug may act by blocking putrescine biosynthesis. Inoculated chickens, in which coccidial lesion development was suppressed by DFMO, resisted subsequent challenge exposure with E tenella, as did nontreated infected control birds which had recovered from infection.

Animals↗
PubMed1981

Chemotherapy and the immune response in protozoal infections.

Available evidence indicates that many of the antiprotozoal drugs currently in use significantly modify the immune response of the host. The effect depends on both the drug and the host. Some drugs enhance the immune response, some are immunosuppressants, and others enhance some types of immune mechanisms while suppressing others. Future efforts in the development of antiprotozoal drugs should consider their effects on both the parasite and the immune response of the host. Also in the chemotherapy of protozoal infections consideration should be given to the combined usage of immunoenhancing agents and antiprotozoal drugs.

Adjuvants, Immunologic↗
PubMed1981

Occurrence of antibody to Trypanosoma cruzi in dogs in the southeastern United States.

Seven of 365 dogs from Georgia and other southeastern states were seropositive for antibody to Trypanosoma cruzi by the complement-fixation (CF) test. Sera from 24 dogs, including the 7 dogs seropositive by CF test, were reactive at dilutions of 1:128 or 1:256 by the direct-agglutination (DA) test. Dogs with positive CF titers were significantly (P less than 0.05) younger than were the dogs in the total population surveyed. The occurrence of antibody to T cruzi was similar, regardless of the dogs' origin, sex, or length of hair. Dogs with specific antibody to T cruzi did not have clinical signs of disease related to the cardiovascular or gastrointestinal systems, the systems most frequently affected in American trypanosomiasis (Chagas' disease). Sera from an additional 20 dogs from Minnesota were examined by the DA test. One of these sera had a reaction at a dilution of 1:2, and 19 sera had no reaction in the DA test for antibody to T cruzi.

Animals↗
PubMed1980

Leishmaniasis: in search of new chemotherapeutic agents.

Members of a class of compounds designated lepidines (8-amino-6-methoxy-4-methylquinoline derivatives) were tested in a hamster-Leishmania donovani model and found to have activity many-fold that of a reference drug meglumine antimoniate. One of them, 8-(7-isopropylaminoheptylamino)-6-methoxy-4-methylquinoline, was found to be 138 times as effective as the standard antimonial drug used.

Aminoquinolines↗
PubMed1979

Adoptive transfer of protection against Trypanosoma cruzi with lymphocytes and macrophages.

Female C57BL/6J mice were infected with Trypanosoma cruzi and subsequently given macrophages or lymphocytes from syngeneic donors which had recovered from the acute infection. Mice which received immune peritoneal macrophages, splenic lymphocytes, or lymph node lymphocytes developed lower mean parasitemias and cumulative mortalities than did recipients of nonimmune cells. Neither peritoneal lymphocytes nor splenic macrophages were protective, however. These studies indicate that splenic and lymph node lymphocytes are effective in transferring protection against T. cruzi, whereas the macrophage is somewhat less effective.

Animals↗