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Biomedical subjects

W L Henley

Publications and source records attributed to W L Henley.

At least 19 recordsLinked to original sources
PubMed1989

Longitudinal study of serum antibody response to bovine corneal protein (BCP 54) in Behçet's disease.

Serum samples from a patient diagnosed as having active Behçet's syndrome with iritis were evaluated by the enzyme-linked immunosorbent assay for antibodies against a purified bovine corneal protein, molecular weight 54,000 daltons (BCP 54). Significantly elevated antibody levels to BCP 54 were found in all serum samples collected over a 2-year period. Anti-BCP 54 antibody levels remained within a very narrow range, at least twofold higher than those of controls. In contrast, no antibody to retinal S antigen was detected. These results indicate the presence of specific anti-BCP 54 autoantibodies in sera from a Behçet's patient and suggest that autoantibodies may play a role in the etiopathogenesis of uveitis.

Adolescent↗
PubMed1983

Focal convulsions associated with subclinical measles infection.

A patient with focal convulsions of sudden onset had cerebrospinal pleocytosis and electroencephalographic evidence of a focal lesion in the right hemisphere. Except for fever, there was no clinical evidence of a viral infection. Measles antibodies were detected in the serum and CSF. The CSF abnormalities resolved, and the patient has been well for 4 years. This case is unusual because of the focal CNS involvement and the lack of any other clinical features of measles infection.

Adolescent↗
PubMed1982

Leucocyte responsiveness to corticosteroids in diabetic retinopathy.

The in vitro response of white blood cells of maturity onset diabetics to corticosteroids was the subject of these experiments; the response was assessed with the leucocyte migration inhibition assay. Leucocytes from patients with nonproliferative retinopathy demonstrated increased responsiveness to corticosteroids in comparison with the white cell response of both controls and patients with proliferative retinopathy. Similarly leucocyte migration inhibition was greater in the insulin independent than in insulin dependent diabetics. Furthermore leucocyte migration responsiveness may be related to duration of the diabetic state. This preliminary study points to the possible importance of corticosteroids and their receptors in retinopathy and angiopathy.

Adrenal Cortex Hormones↗
PubMed1976

Histocompatibility (HL-A) antigens and primary open-angle glaucoma.

To assess the association between open-angle glaucoma and HL-A antigens, the frequencies of 25 HL-A antigens were determined in 49 patients with OAG, and 22 patients with increased intraocular pressure, due to causes other than OAG, using the microcytotoxicity method. The results were compared to 250 individuals from the general population who were tested in the same laboratory at the same period of time. Using rigid statistical analysis, the incidence of the Bw35 antigen was found to be significantly (less than 0.012) higher among OAG patients. In a group of 27 first relatives of OAG patients who were tested at the same time, the frequency of Bw35 antigen was increased compared to the general population. The biological importance of the association between Bw35 and OAG, which may still be a chance deviation, is not yet fully understood. It may indicate that the Bw35 antigen or the HLA loci are among the genetic factors which produce susceptibility to open-angle glaucoma.

Aged↗
PubMed1976

Leucocyte-migration inhibition induced by uveoretinal antigen in patients with diabetic retinopathy.

Leucocyte-migration inhibition was to determine the state of hypersensitivity in 65 diabetic patients with different stages of retinopathy and 21 nondiabetic controls. About one third of the patients with simple or proliferative retinopathy exhibited significant leucocyte-migration inhibition of 0.2 mg/ml. protein concentration of uvreoretinal antigen. In contrast, only one of 15 patients with minimal retinopathy and none of the controls showed significant leucocyte-migration inhibition. Corneal and lenticular antigens did not evoke a cellular immune response in any of the tested individuals. These findings suggest that cell-mediated hypersensitivity to uveoretinal antigen may develop in diabetic patients with prolonged, progressive, simple or proliferative retinopathy.

Adult↗
PubMed1976

Leucocyte migration test in patients after corneal transplantation.

Twenty-four patients with corneal homografts were repeatedly evaluated by the leucocyte migration test using pooled human corneal extract 0.2 mg/ml as antigen. All patients were treated with small doses of local or systemic steroids. If cloudiness of the graft developed, the doses were increased up to 40 mg methylprednisolone or 48 mg triamcinolone daily. Before transplantation, two patients showed inhibition of leucocyte migration. During the third postoperative week seventeen responded with migration inhibition. The grafts remained clear in all but one patient during this period of time. After the second postoperative month, leucocyte migration inhibition was found in none of sixteen patients whose grafts remained clear. Three of seven patients with late graft rejection exhibited migration inhibition and in two of them this response was demonstrated repeatedly several months prior to the clinical reaction. These findings suggest that the test may predict graft failure in some patients.

Adolescent↗