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Biomedical subjects

W L Marshall

Publications and source records attributed to W L Marshall.

At least 19 recordsLinked to original sources

Recovering memories of the offense in "amnesic" sexual offenders.

This paper describes a technique designed to assist sexual offenders to recover memories of their offense. We have consistently observed that some sexual offenders present as having no recall of their offense although they are able to remember other events of the day of the offense. This failure to recall offense details prevents the offenders from making an appropriate disclosure which, in turn, blocks attempts to identify their offense pathways and develop relapse prevention plans. The memory recovery technique we describe is based on experimental literature on memory and we outline its use with 22 clients, 20 of whom showed satisfactory recovery of their memories.

Amnesia↗

Therapist style in sexual offender treatment: influence on indices of change.

This paper describes the results of our review of the broad process literature as well as summarizing two studies examining the influence of the therapist in generating changes in treatment targets among sexual offenders. We conclude that displays of empathy and warmth by the therapist as well as the provision of rewards for progress and some degree of directiveness, maximize the benefits derived from the procedures employed in treating sexual offenders. We also suggest the need for flexibility and encourage program designers not to so overly detail their treatment manuals that the influence of the therapist is minimized.

Attitude of Health Personnel↗

Effect sizes in the treatment of sexual offenders.

This article considers the benefits of sexual offender treatment in terms of the magnitude of the effect size produced by these interventions. Comparisons are made of the effect sizes with those generated by treatment of other offenders, by treatment for mental health problems, and by treatment for physical health problems. In all cases, effect sizes with sexual offenders are comparable to (and in some cases better than) effect sizes for the treatment of the other groups. As a final note, it is suggested that using a harm reduction index to estimate effect sizes for treatment with sexual offenders would produce more meaningful results.

Humans↗

Victim empathy, social self-esteem, and psychopathy in rapists.

The purpose of the present study was to compare the responses of 27 incarcerated rapists and 27 incarcerated nonsexual offenders using the Rapist Empathy Measure (targeting victim specific empathy deficits) and to examine the relationship between empathy with self-esteem and psychopathy for both groups. The Social Self-Esteem Inventory was used as a measure of perceived social competence and the Psychopathy Checklist-Revised (PCL-R; Hare, 1991) was used as a measure of psychopathy. All participants completed the two self-report questionnaires on empathy and self-esteem; in addition, the rapists were required to complete an extra section of the empathy measure that assessed their empathic responses to their own victims. Demographic information and psychopathy scores were obtained by reviewing institutional files. When psychopathy scores were not available, subjects participated in a semi-structured interview and were scored on the Psychopathy Checklist-Revised by the researcher. Rapists demonstrated more empathy than the nonsexual offenders toward women in general and the same degree of empathy as the nonsexual offenders toward a woman who had been a victim of a sexual assault by another male. Of particular importance were the within-group comparisons across victim type for the rapists which revealed significant empathy deficits toward their own victim(s). Interestingly, no differences were found between the rapists and nonsexual offenders in terms of self-esteem and psychopathy, and neither self-esteem nor psychopathy significantly predicted empathy for either group. It was concluded from the present study that rapists may suppress empathy primarily toward their own victim rather than suffer from a generalized empathy deficit. It is suggested that empathy deficits in rapists might better be construed as cognitive distortions specific to their victims and should be addressed in that manner in treatment.

Adult↗

A brief history of behavioral and cognitive behavioral approaches to sexual offenders: Part 1. Early developments.

This is the first of two papers which briefly outline the development of behavioral and cognitive behavioral treatment of sexual offenders from the mid-1800s to 1969. We first consider the historic role of Sigmund Freud and note that a broad scientific interest in deviant sexual behaviour was well established by 1900. In the early to mid-20th century, two psychologies were prominent in the development of behaviorial approaches, those of John B. Watson and Alfred Kinsey. Behavior therapy for a variety of problems emerged in the 1950s and soon found application to deviant sexuality. The development of penile plethysmography helped to focus interest on deviant sexual preference and behavior. While nonbehavioral approaches to sexual offenders paralleled these developments, a combination of behavioral and cognitive behavioral treatments began to emerge in the late 1960s which ultimately developed into the approaches more commonly seen today.

Behavior Therapy↗

Distorted attitudes and perceptions, and their relationship with self-esteem and coping in child molesters.

Two studies were conducted to compare various aspects of child molesters, non-sexual offenders, and community-based nonoffenders. These studies were aimed at examining some implications of our general model of sexual offending. Study 1 compared the responses of these 3 groups on measures of self-esteem, attitudes toward women and children, and social desirability tendencies. The only observed difference was that child molesters had significantly lower self-esteem than did the other 2 groups. In Study 2, child molesters displayed more cognitive distortions about sex between adults and children than did nonsexual offenders or nonoffenders. However in this study child molesters scored in the same range as the other participants on self-esteem and the tendency to use sex as a way of coping with problems. The results are discussed in terms of the differences between the present findings and earlier studies, and their implications for future research.

Adaptation, Psychological↗

Diagnosing sexual sadism in sexual offenders: reliability across diagnosticians.

On the basis of detailed accounts of offences committed by 12 dangerous sexual offenders and of descriptions of their life histories, their responses to various tests, self-reports of offenders' sexual interests and activities, and results of phallometric evaluations, 15 expert forensic psychiatrists diagnosed whether each offender met the criteria for sexual sadism. The psychiatrists also indicated their confidence in the diagnoses they made and rated the relevance to the diagnosis of sexual sadism for various features of the offence and the offender. Results revealed unsatisfactory levels of diagnostic agreement among the psychiatrists. On the other hand, they agreed quite well on the importance for the diagnosis of several of the offence features described. Suggestions are offered for clinical practice.

Humans↗

Issues concerning the reliability and validity of the diagnosis of sexual sadism applied in prison settings.

This study examined limited aspects of the diagnoses of sexual sadism among incarcerated sexual offenders. The diagnoses examined in this study were made by experienced forensic psychiatrists following DSM-III-R or DSM-IV criteria. Archival data was extracted on 51 sexual offenders for whom a psychiatric evaluation had been requested. Analyses of offense history and features, offender self-reports, and phallometric data, indicated few differences between those offenders diagnosed as sadists and those not so diagnosed. In fact, where there were differences, the data indicated that the nonsadists were the most deviant. The results are discussed in terms of their meaning for both forensic practice in prisons and the value of the diagnosis of sexual sadism.

Antisocial Personality Disorder↗

Empathy deficits and cognitive distortions in child molesters.

An attempt was made to examine the thesis that the apparent empathy deficits in child molesters are simply another aspect of their self-serving tendency to distort information by, in this case, failing to recognize victim harm. Thirty-four child molesters were compared on a victim empathy measure and a measure of cognitive distortions, with 24 nonsex offenders and 28 nonoffending males. Child molesters displayed greater cognitive distortions than the other subjects and their greatest empathy deficits were toward their own victims. Consistent with the theory being examined it was found that the empathy scores of the child molesters toward their own victims were significantly correlated with the responses to the cognitive distortions scale. The results are discussed in terms of their implications for theory and practice.

Adult↗

Treatment of sexual offenders who are in categorical denial: a pilot project.

This paper describes an approach to treatment for sexual offenders who are in categorical denial. Other efforts to have them, at least partially, admit responsibility had failed and they were to be released from prison without any treatment. Evidence that suggests denial is not predictive of risk and that treatment may reduce the risk of these offenders is reviewed. Essentially, this paper offers a possible approach to dealing with these intractable deniers which, it is suggested, is better than not trying to modify their risk, and that may prove to be effective.

Adaptation, Psychological↗

Hostility toward women and victim empathy in rapists.

The present study examined empathy and hostility toward women among 32 rapists, 28 nonsex offenders, and 40 nonoffender males. Results indicated that rapists were significantly less empathic than either of the other two groups toward women who had been sexually assaulted by an unknown assailant. They were also significantly less empathic toward their own victims than toward any other women, and they were markedly more hostile toward women than were the other subjects. Finally, among the rapists, hostility toward women was significantly negatively related to their empathy toward their own victims.

Adult↗

Phallometric testing with sexual offenders: limits to its value.

In many settings phallometric evaluations of sexual arousal are routinely conducted with sexual offenders and these evaluation procedures also serve as research instruments. There are, however, problems with the psychometric bases of these assessments, and studies reporting their use have so many idiosyncratic features that comparisons are of dubious value. Evidence concerning the reliability and criterion validity of phallometric testing leaves a lot to be desired, although the research has suggested an important but limited value in predicting subsequent recidivism. Suggestions are made for further research and for the clinical use of phallometric assessments within more comprehensive evaluations of sexual offenders.

Adult↗

Childhood attachments, sexual abuse, and their relationship to adult coping in child molesters.

The present study examined the parent-child attachments, typical coping styles, and childhood sexual abuse among 30 child molesters, 24 nonsexual offenders, and 29 nonoffenders. The results indicated that all subjects reported greater security in their attachments to their mothers than to their fathers and the insecure patterns of childhood attachments were related to ineffective adult coping. The only difference observed in characteristic coping showed that child molesters were more likely to engage in emotion focused strategies. Child molesters reported having experienced high levels of childhood sexual abuse and these experiences appear to have been more distressing to them than to other subjects. The results are discussed in terms of their implications for theory and treatment.

Adaptation, Psychological↗

Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alpha.

The level of ongoing HIV-1 replication within an individual is critical to HIV-1 pathogenesis. Among host immune factors, the cytokine TNF-alpha has previously been shown to increase HIV-1 replication in various monocyte and T cell model systems. Here, we demonstrate that signaling through the TNF receptor family member, the lymphotoxin-beta (LT-beta) receptor (LT-betaR), also regulates HIV-1 replication. Furthermore, HIV-1 replication is cooperatively stimulated when the distinct LT-betaR and TNF receptor systems are simultaneously engaged by their specific ligands. Moreover, in a physiological coculture cellular assay system, we show that membrane-bound TNF-alpha and LT-alpha1beta2 act virtually identically to their soluble forms in the regulation of HIV-1 replication. Thus, cosignaling via the LT-beta and TNF-alpha receptors is probably involved in the modulation of HIV-1 replication and the subsequent determination of HIV-1 viral burden in monocytes. Intriguingly, surface expression of LT-alpha1beta2 is up-regulated on a T cell line acutely infected with HIV-1, suggesting a positive feedback loop between HIV-1 infection, LT-alpha1beta2 expression, and HIV-1 replication. Given the critical role that LT-alpha1beta2 plays in lymphoid architecture, we speculate that LT-alpha1beta2 may be involved in HIV-associated abnormalities of the lymphoid organs.

Antigens, CD↗

U937 cells overexpressing bcl-xl are resistant to human immunodeficiency virus-1-induced apoptosis and human immunodeficiency virus-1 replication.

Many viruses, including human immunodeficiency virus type 1 (HIV-1), induce apoptosis and are affected by cellular expression of antiapoptotic genes. We sought to examine the effect of antiapoptotic gene expression on HIV replication by transfecting the promyelomonocytic cell line U937 with the bcl-xl gene to obtain clones of U937 cells that overexpressed bcl-xl (designated U937bcl-xl), a negative control U937 clone transfected with vector alone (designated U937neo) and a clone overexpressing bcl-2 (designated U937bcl-2). After infection with HIV-1, U937neo cells underwent apoptosis four times as frequently as the U937bcl-xl cells. Furthermore, U937bcl-xl cells produced 5-fold less HIV-1 protein than U937neo, whereas U937bcl-2 produced at least 2-fold more p24 than the U937neo control. Transient coexpression of bcl-2 or bcl-xl decreased HIV production and transcription from the HIV LTR. To define the mechanism by which bcl-xl, but not bcl-2, inhibits HIV expression, we examined bcl-2 and bcl-xl expression after HIV infection and CD4 cross-linking. Although HIV-1 infection or cross-linking CD4 led to a decrease in expression of bcl-2, it had no effect on bcl-xl expression. These results provide a mechanism for the resistance of U937bcl-xl transfectants, but not U937bcl-2 transfectants, to HIV-1 replication in monocytic cells in vitro. Therapies that up-regulate bcl-xl expression potentially provide a novel means to decrease the destructiveness of HIV-1.

Apoptosis↗