Biomedical subjects

W L Mason

Publications and source records attributed to W L Mason.

4 recordsLinked to original sources

PubMed1993

Carbohydrate ingestion during exercise: liquid vs solid feedings.

Six trained men were studied during 2 h of exercise at 65% VO2max to examine the influence of the physical form of carbohydrate supplementation on blood glucose and insulin responses. Three exercise tests were performed in randomized order, at least 1 wk apart. Subjects ingested 25 g of carbohydrate or 500 ml of a sweet placebo (CON) at 0, 30, 60, and 90 min of exercise. Carbohydrate was ingested as 500 ml of a 5% rice-based liquid (L-CHO) or as a 31-g food bar (S-CHO). No differences in oxygen uptake, respiratory exchange ratio, or heart rate were observed between trials. Blood glucose levels were higher (P < 0.05) throughout exercise when carbohydrate was ingested, compared with CON. No differences in blood glucose during exercise were observed between L-CHO and S-CHO. Plasma insulin levels were higher (P < 0.05) after 120 min of exercise when carbohydrate was ingested. The results of this study indicate that carbohydrate supplements with differing physical form (liquid vs solid) but equal carbohydrate content produce similar blood glucose and insulin responses during exercise.

Adult↗

PubMed1980

Treatment of tularemia, including pulmonary tularemia, with gentamicin.

An alternative to streptomycin for treatment of possible tularemia would be useful on occasions when a patient develops a perplexing pneumonia that does not respond to initial treatment. In geographic areas where tularemia is endemic, an antimicrobial drug that is bactericidal for Francisella tularensis and is also effective against a spectrum of common pulmonary pathogens, including the Enterobacteriaceae and most strains of Pseudomonas aeruginosa, would be desirable. The purposes of this report are (1) to describe observations regarding the in vitro susceptibility of Francisella tularensis to streptomycin, kanamycin, and gentamicin; (2) to describe in vivo efficacy of these drugs in mouse tularemia; (3) to describe the results in 10 patients with tularemia treated with gentamicin. Gentamicin was bactericidal for Francisella tularensis in vitro, was effective in mouse tularemia when given in large doses, and was effective in humans when given in the standard recommended dose.

Aged↗

PubMed1978

Steroid hydroxylase induction in cultured human lymphocytes: effects of the menstrual cycle.

Steroid hydroxylases (SAH) are inducible in cultured human lymphocytes following treatment with estradiol-17beta. The enzyme systems induced are carbon monoxide sensitive and convert estradiol-17beta to a metabolite chromatographically indistinguishable from estriol. The level of inducibility of SAH varies drastically over a normal menstrual cycle with maximum induction in the late follicular phase and minimum induction during the luteal phase. The use of an oral contraceptive containing both a synthetic progestogen and ethynyl estradiol reduced SAH induction levels to those typically seen during the luteal phase of the menstrual cycle.

Cells, Cultured↗

PubMed1968

Vaginal agenesis.

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Adolescent↗