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Biomedical subjects

W L Ng

Publications and source records attributed to W L Ng.

At least 55 records · Page 3Linked to original sources
PubMed1985

Unusual transformations of renal involvement in systemic lupus erythematosus.

The clinical course of a woman with systemic lupus erythematosus demonstrated that renal involvement in this disease can change, both in the predominant site of renal injury and in the pattern of glomerular lesions. Over 50 months she had first tubulo-interstitial lupus nephritis with no glomerular change, then a membranous nephropathy with disappearance of tubulo-interstitial inflammation, and finally crescentic glomerulonephritis. This case emphasizes the need for close follow-up of all lupus patients regardless of their initial renal manifestations and pathology.

Adolescent↗
PubMed1985

Sialadenoma papilliferum.

Sialadenoma papilliferum is a rare benign papillary intraoral tumour most frequently affecting men over the age of 50. The tumour bears many similarities to adenolymphoma of the parotid and may be considered a variant of the latter. A case is presented and the literature is reviewed.

Adenoma, Pleomorphic↗
PubMed1985

Gentamicin nephropathy in a neonate.

The clinical and autopsy findings in a premature baby who died of acute renal failure after therapy with gentamicin (5 mg/kg/day) and penicillin are presented. The serum gentamicin concentration had reached toxic levels when anuria developed. Numerous periodic acid Schiff (PAS) positive, diastase resistant cytoplasmic inclusion bodies which appeared as myelin figures in cytosegresomes under the electron microscope were identified in the proximal convoluted tubules. The pathological changes induced by gentamicin in the human neonatal kidneys have not been previously reported.

Gentamicins↗
PubMed1985

Diethylnitrosamine induced enzyme altered areas in the rat liver: effect of partial hepatectomy.

The effect of partial hepatectomy on the growth of enzyme-altered areas, induced in male albino Wistar rats by giving them diethylnitrosamine (DEN) in their drinking water, was studied. This was performed morphometrically by means of light microscopy and enzyme histochemistry. The results showed that the enzyme-altered areas increased significantly in size for two weeks following the partial hepatectomy but not thereafter. This finding suggested that DEN induced enzyme-altered areas can respond to a proliferative stimulus, but the response appeared transient.

Animals↗
PubMed1985

Acute deterioration in renal function in systemic lupus erythematosus.

In a retrospective study of 196 hospital admissions for systemic lupus erythematosus (SLE) over five years acute deterioration in renal function occurred in 36 admissions (18.4 per cent) and was the commonest mode of deterioration of renal function in SLE patients. Active lupus accounted for the majority of cases, with crescentic WHO IV lupus glomerulonephritis (greater than or equal to 50 per cent crescents) the commonest underlying pathology. In 19 per cent of these 36 admissions, it was most likely that concurrent infections at onset precipitated the episodes. Central nervous system lupus and infections were the major causes of death. Recovery of renal function was, however, achieved in 76 per cent using mainly pulse methylprednisolone and immunosuppressives as well as elimination of provoking factors especially infections.

Acute Disease↗
PubMed1984

Forestomach squamous papillomas in the rat: effect of dietary zinc deficiency on induction.

Administration of N-nitrosodimethylamine (NDMA) to zinc deficient rats intragastrically twice weekly for 8 weeks resulted in the development of forestomach tumors in 63% of treated animals. The tumors were frequently found at the junction between the fore and glandular stomach and were multiple. Smaller numbers of tumors were also present in the more proximal parts of the forestomach. All tumors were squamous papillomas. Similar tumors were not observed in zinc sufficient pair-fed rats given NDMA. These findings showed that NDMA, a non-esophageal and non-forestomach carcinogen in the rat, was tumorigenic in the presence of zinc deficiency.

Animals↗
PubMed1984

Tubular dysfunction in systemic lupus erythematosus.

20 patients with systemic lupus erythematosus undergoing renal biopsies had their tubular function assessed by maximal concentrating ability, maximal urinary acidification and fractional urinary excretion of beta 2-microglobulin. 80% of patients showed disturbances in one or more of the parameters tested with fractional beta 2-microglobulin excretion being most frequently abnormal. No correlation was found between the histological changes and functional disturbances.

Adolescent↗
PubMed1984

Peripheral glomerular capillary wall lesions in IgA nephropathy and their implications.

Peripheral glomerular capillary walls were studied in 26 cases of IgA nephropathy by means of the transmission electron microscope. Ultrastructural abnormalities were identified in 11 cases (42%). Abnormalities of the glomerular basement membrane (GBM) were the most frequent change which consisted of localized thinning, lamination, irregular thickening, disruption, membranolysis and aneurysmal dilatation of the GBM. Subendothelial electron dense deposits were seen. Necrosis and detachment of the podocytes from the GBM were also encountered. The changes were correlated with the clinical findings at the time of diagnosis which showed a significant correlation of these peripheral glomerular capillary wall lesions with proteinuria. With light microscopy, crescents were significantly more frequently seen in the cases showing the ultrastructural capillary wall abnormalities than those without. This observation suggested that local peripheral glomerular capillary wall damage was an important factor in the pathogenesis of the extracapillary lesions in IgA nephropathy.

Adult↗
PubMed1984

N-nitrosodimethylamine-induced forestomach tumours in male Sprague-Dawley rats fed a zinc-deficient diet.

Fifty-one zinc-deficient rats and 46 zinc-sufficient, pair-fed controls were administered N-nitrosodimethylamine intragastrically at a dose level of 2 mg/kg body weight, twice weekly for three weeks, followed by 4 mg/kg body weight of the same carcinogen twice weekly for another five weeks. After 45 weeks, none of the control rats had developed epithelial abnormalities in the oesophagus or forestomach or any lesion in other tissues. Oesophageal epithelial hyperkeratosis was detected in all zinc-deficient rats, but no tumour was found. Hyperkeratosis and acanthosis were found in the forestomach of 100% and 88%, respectively, of the zinc-deficient rats; 63% of the zinc-deficient rats also developed squamous papillomas in the forestomach.

Animals↗
PubMed1984

Crescentic lupus glomerulonephritis.

Crescentic lupus glomerulonephritis (greater than or equal to 50% crescents) occurred in 16% of systemic lupus erythematosus (SLE) patients biopsied over a 32-month period. All had underlying WHO class IV lupus nephritis. These patients more frequently manifested with acute renal failure usually of the non-oliguric type, had heavier proteinuria and lower serum albumin, but were otherwise indistinguishable from non-crescentic WHO class IV lupus nephritis in their other renal and extrarenal manifestations or in their serological findings. Crescentic lupus glomerulonephritis may occur in patients at first presentation with SLE, or develop in patients after prolonged follow-up initially for lupus nephritis of WHO class IV or other classes. Combined methylprednisolone pulse therapy, immunosuppressives, antiplatelet agents with or without anticoagulant produced good initial responses. Prognosis was unfavorable for inadequately treated patients or for patients with persistent nephrotic syndrome and crescents.

Adolescent↗
PubMed1983

Disseminated tuberculosis in a renal transplant recipient.

A case of disseminated tuberculosis in a renal transplant recipient is presented. Tuberculosis can occur in the early postoperative period and is potentially curable. It should be vigilantly looked for in every case of post-transplant infection.

Humans↗
PubMed1983

Intravenous methylprednisolone pulse therapy in minimal change nephrotic syndrome.

The effectiveness of intravenous methylprednisolone pulses in 20 mg/kg/day for three consecutive days was compared with a more conventional oral prednisone regime in inducing remission in adult patients presenting with first episodes of minimal change nephrotic syndrome. Methylprednisolone was significantly less effective and failed to induce remission in six of nine patients within two weeks of treatment, while the oral prednisone regime was uniformly effective in all eight patients within five weeks. Of the six non-responders to methylprednisolone five subsequently remitted with oral prednisone, and one with cyclophosphamide. Except for one patient in the oral prednisone group who had acute gastritis with bleeding, no serious side-effect was seen with either treatment regimes.

Adolescent↗
PubMed1983

A scanning electron microscope study of isolated glomeruli in glomerulonephritis.

Glomeruli from 48 cases of glomerulonephritis (Gn) were isolated and studied by means of the scanning electron microscope (SEM). Overall glomerular loss due to processing was 2.4%. SEM of these isolated glomeruli showed good preservation of glomerular structure. Changes of the podocyte cell body and its foot processes were noted and correlated with light microscopic morphology. Individual podocyte necrosis, variable foot process fusion and cell body swelling were seen in IgA nephropathy. Podocyte degeneration with separation from the glomerular basement membrane was evident in idiopathic minimal change Gn while idiopathic membranous Gn was characterized by globular swelling of the podocyte cell bodies. In focal sclerosing Gn, large spherical bodies arising from swollen podocyte cell bodies were frequently encountered. Innumerable microvilli and small spherical bodies characterized membranoproliferative Gn. Variable podocyte cell body swelling, microvilli and small spherical bodies were seen in cases of lupus nephritis. Taken alone, none of the SEM changes were diagnostic. However, when the type of the change, the severity and the combination of the changes were considered as a whole, they were indicative of what light microscopy might reveal and helpful in differentiating between idiopathic minimal change Gn and focal sclerosing Gn.

Basement Membrane↗
PubMed1983

Is sclerosing hemangioma of lung an alveolar mixed tumour?

A case of a peripheral lung tumour histologically categorized as a sclerosing hemangioma of the lung is presented. Ultrastructurally, the tumour is composed of a mixture of epithelial and mesenchymal elements in varying stages of differentiation. Type II pneumocytes are identified as one epithelial component, while primitive mesenchymal cells with a tendency to develop into pericytes are the predominant mesenchymal component. The tumour appears to differentiate along the line of the pulmonary alveolar septa, and should be designated as a 'pulmonary alveolar mixed tumour'.

Child↗