Biomedical subjects

W L Woo

Publications and source records attributed to W L Woo.

3 recordsLinked to original sources

PubMed2006

Nonlinear signal separation for multinonlinearity constrained mixing model.

In this letter, a new type of nonlinear mixture is derived and developed into a multinonlinearity constrained mixing model. The proposed signal separation solution integrates the Theory of Series Reversion with a polynomial neural network whereby the hidden neurons are spanned by a set of mutually reversed activation functions. Simulations have been undertaken to support the theory of the proposed scheme and the results indicate promising performance.

Algorithms↗

PubMed2006

Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: identification of a novel mutation in inhA.

Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.

Alleles↗

PubMed1996

Synthesis and biological evaluation of 3-(prop-2-enyl)- and 3-(prop-2-ynyl)pyrrolidine-2,5-dione derivatives as potential aromatase inhibitors.

3-(4'-Aminophenyl)pyrrolidine-2,5-dione (WSP3), a known reversible inhibitor of P450 aromatase, was modified using molecular graphics and our model of reversible inhibitor and substrate binding to resemble 10 beta-prop-2-ynylestr-4-ene-3,17-dione (PED), a mechanism-based inactivator of the enzyme. The analogues prepared were 3-substituted 3-(prop-2-enyl) or 3-(prop-2-ynyl) pyrrolidine-2,5-diones and their N-alkyl derivatives. The reported compounds demonstrated no irreversible (time-dependent) inhibition of the human placental P450 aromatase enzyme. However, some reversible activity was seen in several of the 3-(prop-2-ynyl) compounds.

Aminoglutethimide↗