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Biomedical subjects

W Laass

Publications and source records attributed to W Laass.

At least 19 recordsLinked to original sources
PubMed1980

Therapy of acute oral poisoning by organic solvents: treatment by activated charcoal in combination with laxatives.

High doses of activated charcoal effectively decrease enteral absorption of organic solvents. Insufficiently large amounts of liquid paraffin or castor oil showed no protective effect. On the contrary, blood levels of some solvents were increased, especially by paraffin. Therefore, the use of paraffin in the therapy of solvent intoxications prior to the application of activated charcoal cannot be generally recommended.

Animals↗
PubMed1978

Antiviral activity of dipyridamole derivatives.

Among 46 novel pyrimido [5.4-d] pyrimidine derivatives, 26 compounds were found to exhibit antiviral activity as revealed in a test programme against Mengo, Coxsackie B1, fowl plague, vaccinia and pseudorabies viruses, as concerns inhibition of plaque formation and of infectious virus yield. Attempts to disclose structure-activity relationships by discriminant analysis pointed to a possible importance of hydrophobic substitution for the antiviral effectiveness against Mengo virus of the derivatives investigated.

Antiviral Agents↗
PubMed1978

[Use of structure-activity analysis in toxicology].

An account is given of principles and methods of quantitative structure-action analysis which have promising applications in toxicology. Particular reference is made to the development of active principles with low toxicity for warm-blooded animals, early assessment of toxicity of recently synthetised or envisaged compounds of one substance class of which the toxicity of some agents has already become known, and appraisal of unspecific toxic effects.

Animals↗
PubMed1977

Histological and histochemical studies on the rat brain under conditions of carbon disulfide intoxication.

The brains of 35 male Wistar rats weighing 250 g were histologically and histochemically examined after a chronic intoxication due to five-month exposure to carbon disulfide. Morphologically, myelin sheath disruptions within the longitudinal tract systems of the spinal cord, destructions of individual ganglion cells in all brain regions and elective parenchyma necroses in the frontal and parietal cerebral cortices were found. The histochemical assays for enzyme activities of monoamine oxidase, ATPase, glucose 6-phosphatase, acetylcholine esterase and succinic dehydrogenase in the entire central nervous system revealed values identical to those obtained for control animals. Only succinic dehydrogenase and acetylcholine esterase revealed focal reduction in activities within the elective parenchyma necroses. After twenty-week duration of experiments a moderate decrease in activities of arylsulfatases and glutamic dehydrogenase in the entire central nervous system was found. Eventual causes responsible for these changes are discussed.

Animals↗