[Treatment and follow up care of Bechterew patients].
Explore the source record for details and available documents.
Aftercare↗
Biomedical subjects
W Laschner
Publications and source records attributed to W Laschner.
[Results of long-term D-penicillamine therapy in chronic polyarthritis].
In 34 patients with severe rheumatoid arthritis the therapeutic efficacy of 600 mg/die of D-penicillamine was evaluated for five years. Patients were included in the study only if the duration of their disease exceeded 6 months (upper limit 12 months), and there was involvement of 6 or more joints and an elevated erythrocyte sedimentation rate (1 Hour values greater than or equal to 25 mm). In 9 patients (26%) a decline in the activity index could be observed, but 7 of these subjects had a deterioration of findings as assessed by x-ray. The increase of the activity index indicated no therapeutic benefit in 25 patients (74%), which could be confirmed in all subjects by x-ray.
Adult↗
[Clinical value of histomorphologic studies of joint capsules].
The clinical significance of the histomorphological evaluation of synovial tissue from 389 patients with joint diseases was studied. From these data we conclude: (1) the histomorphological diagnosis in joint diseases is rarely of decisive value (6.2%); (2) in 23.1% of cases the histomorphological diagnosis is judged to be of clinical assistance; (3) the histomorphological grading of the inflammatory reaction in the joint under study corresponds in approximately two out of three cases to the clinical judgement.
Arthritis, Rheumatoid↗
[Effectiveness of D-penicillamine therapy in chronic polyarthritis].
In 52 patients with severe rheumatoid arthritis the therapeutic efficacy of 600 mg/die of D-penicillamine was evaluated for two years in a prospective trial. Patients were included in the study only if the duration of their disease exceeded 6 months (upper limit 12 months), and there was involvement of 6 or more joints and an elevated erythrocyte sedimentation rate (1 hour values greater than or equal to 25 mm). In 26 patients (50%) a decline in the activity index could be observed, but 18 of these subjects had a deterioration of findings as assessed by X-ray. The increase of the activity index indicated no therapeutic benefit in 26 patients (50%), which could be confirmed in 23 subjects by X-rays.
Adult↗
[The effect of basic therapeutic procedures on the immunoregulatory T-cell apparatus in patients with chronic polyarthritis].
Five by five patients with rheumatoid arthritis were treated with gold salts, D-penicillamine and cyclophosphamide. The T-lymphocyte subpopulations were measured. In patients, treated with gold salts or D-penicillamine, we did not find alterations of the number of TG- and TM-lymphocytes. The daily treatment with 100 mg cyclophosphamide will result in a significant reduction of TG-lymphocytes.
Arthritis, Rheumatoid↗
[Enzyme histochemical demonstration of immunoglobulins in joint capsules in chronic polyarthritis and active inflammatory arthritis].
In rheumatoid arthritis, immunoglobulins are detectable in joint capsules within the subsynovial space and in superficial cell layers in significantly greater frequency as compared with osteoarthritis. These extravascular immunoglobulins were demonstrated in good agreement by a three-step immuno-peroxydase technique and a two-step alkaline phosphatase technique, the former being preferable because of reduced unspecific background staining. Both techniques are at least as sensitive as conventional immunofluorescence while in addition rendering the histological evaluation of the entire joint capsule possible. Thus, the detection of extravascular immunoglobulins can be related to their activity as mediators of inflammation. Accordingly, hypertrophy and hyperplasia of superficial cells as well as stromal proliferation could be consequences of immunoglobulins or immune-complexes persisting in the joint capsule. The histochemical techniques described here are suitable to morphologically distinguish osteoarthritis from chronic polyarthritis in histological sections. The presence of immunoglobulins in superficial cell layers and/or extravascular spaces argues in favour of rheumatoid arthritis.
Antigen-Antibody Complex↗
[Distribution of immunoglobulin classes in joint capsules in osteoarthritis (arthrosis) and chronic polyarthritis].
The distribution of the various classes of immunoglobulins (IG) in synovial membranes in rheumatoid arthritis (RA) and in osteoarthritis (OA) is analyzed. Both plasma cells and extravascular deposits of immunoglobulins are stained using class-specific antisera and the peroxidase-antiperoxidase technique. It can be shown that the local humoral immune response in RA-Synovialitis occurs at a higher level than that of OA; inflammatory infiltrates are denser and plasma cells are activated to a higher degree which is evident in the greater intensity of cytoplasmic staining. While there is no difference in the relation between singular classes of IG in these two groups of diseases, the fraction of plasma cells synthesizing an immunoglobulin is greatly elevated in RA-Synovialitis and there is a correlation of this to the morphological degree of RA-Synovialitis. This applies even more to extravascular deposits of IG with rheumatoid-factor-activity. The determination and staining of extravascular immunoglobulins with a polyvalent anti-human-serum or with antisera specific for the gamma, alpha, and mu-antigens of heavy chains as well as the demonstration of rheumatoid-factor activity of these IG constitute a possibility to histochemically discriminate between RA-Synovialitis and OA-induced synovialitis. In OA, intensely stained areas of IG with rheumatoid-factor-activity located extravascularly are never found.
Antibody Formation↗