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Biomedical subjects

W Lawkowicz

Publications and source records attributed to W Lawkowicz.

At least 19 recordsLinked to original sources
PubMed1979

Lysozyme in the serum, urine and peripheral blood leukocytes in patients with immunocytoma.

Lysozyme activity was determined in the serum, urine and leukocytes of 53 patients with immunocytoma and 24 patients with lymphoproliferative syndromes without associated monoclonal gammapathy. In patients with multiple myeloma the frequency of low serum lysozyme activity and high leukocyte lysozyme activity was higher. In the cases with renal failure, lysozyme activity was raised in serum and urine, and the 24-hour urinary lysozyme excretion was increased. In 7 patients with increased urinary lysozyme excretion no clinical or laboratory evidence of renal complications was found. Relative monocytosis in peripheral blood was observed in half of the cases of multiple myeloma, and in these patients also in about half of the cases the lysozyme activity was raised in the leukocytes and urine, and the 24-hour urinary lysozyme excretion was increased. In patients with Hodgkin's disease, lymphosarcoma and chronic lymphatic leukemia the frequency of low serum lysozyme activity was increased.

Adult↗
PubMed1977

Lymphocyte response in in vitro cultures to some mitogens, and serum immunoglobulin levels in aged subjects.

Capacity of lympocytes for blastic transformation in in vitro cultures under the influence of PHA and PWM was studied in 40 subjects aged 20--60 years and in 43 aged 60--100 years. In the higher age group, in about 25% of cases, low percentages of blasts in cultures stimulated with PHA and PWM were observed. In 101 subjects aged 65--100 years, the mean level of IgA in serum was significantly higher compared with the 20--40-year age group. In some cases, levels of two or three immunoglobulin classes were raised. The unexplained changes in the reaction of lymphocytes to PHA and PWM and in levels of serum IgG were attributed to the old age of the subjects.

Adolescent↗
PubMed1976

Autoimmune haemolytic anaemia in children.

Forty-four children with autoimmune haemolytic anaemia (AIHA) are described: 31 had acute, subacute or chronic disease with warm autoantibodies and 13 had acute or chronic anaemia with cold autoantibodies. The commonest forms were the acute and subacute types with warm autoantibodies and these were more frequent in young children, while chronic AIHA occurred mainly among children at puberty. In about 16% the anaemia was accompanied by a chronic disorder but in over 50% the anaemia was preceded by an acute infection or immunization. The former gave rise mainly to chronic anaemia, but the latter was associated with the acute and subacute forms. In general the prognosis was good and death was never caused by anaemia per se. The prognosis was worse in patientw with clinical features of thrombocytopenia and bleeding and with the immunological findings of free autoantibodies in the serum and a positive direct antiglobulin test. In acute and subacute forms, treatment with corticosteroids and sometimes with blood transfusions was effective. In chronic forms of the disease it was often necessary to give additional immunosuppressive drugs or/and to perform a splenectomy.

Acute Disease↗
PubMed1976

[Neoplastic variant of acute erythroblastotis--proerythroblastoma].

In two case of aorthochromatic anaemia refractory to treatment with granulocytopenia and thrombocytopenia without significant enlargement of abdominal viscera a hypothesis of uncontrolled proliferation involving proerythroblasts is put forward on the basis of bone marrow findings. This proliferation seems to be confined to a single focus-bone marrow, without evidence of peripheral dissemination. Profound dysplastic changes of proerythroblasts are suggestive of neoplastic growth.

Acute Disease↗