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Biomedical subjects

W Lichtenegger

Publications and source records attributed to W Lichtenegger.

10 recordsLinked to original sources
PubMed1978

Clinical experience in the application of the tissue pH electrode.

Only after placing the pH electrode through an incision could its point enter deep enough into the tissue. The storage of the pH electrode in a reference buffer considerably improved the stability of the electrode. The ECG electrode is at present the weakest link in the realization of continuous pH measurements. Improvements should be effected mainly with the ECG electrode, the electrode cable and the application instruments.

Electrocardiography↗
PubMed1978

Practical experience in the usage of a pH electrode.

A total of 57 continuous pH measurements have been carried out at the University Clinic of Gynecology in Graz since September 1976. In 41 cases diagrams were suitable for evaluation. In fetal distress the pH curves showed increasing waves synchronous with labor activity. A linear pH curve seems to preclude imminent danger to the fetus. A decline in the pH curve prior to delivery may be caused either mechanically or by fetal distress.

Electrodes↗
PubMed1978

Insulin levels in amniotic fluid. Management of pregnancy in diabetes.

A correlation between high insulin levels in amniotic fluid and the appearance of diabetogenic fetal morbidity was found in radioimmunoassays of 487 samples of the fluid. The mean insulin level in metabolically normal pregnancies rose from 9 muU/ml (Week 27) to 15 muU/ml (Week 40). The insulin level in amniotic fluid of diabetic patients was elevated up to 27 times the mean. Insulin levels in the umbilical cord and urine of newborns of diabetic mothers were also elevated, to 29 and 21 times the mean, respectively. Elevation of insulin levels in amniotic fluid portends diabetogenic fetal morbidity. High and rising insulin levels at an early stage (26-28 weeks) may indicate a high risk of preterm onset of labor. Regular adjustment of metabolic compensation on the basis of amniotic fluid insulin made it possible to reduce the level in 12 of 17 pregnant diabetic women by increasing insulin dosage. The 12 women were thereby enabled to carry their pregnancies to term and to await the onset of spontaneous labor without diabetogenic fetal morbidity. Beta-stimulating agents affect glucose management and may cause elevated insulin levels in amniotic fluid.

Amniotic Fluid↗
PubMed1978

Alpha-fetoprotein content of amniotic fluid in normal and abnormal pregnancies.

Elevation above the normal range of alpha-fetoprotein (AFP) concentration in amniotic fluid occurs in the presence of certain fetal anomalies. The value of a new method for radioimmunoassay of APF in amniotic fluid was tested by an analysis of 486 samples taken by amniocentesis at various stages of pregnancy. The normal range of concentrations during pregnancy was established by 348 samples from healthy women with normal pregnancies. This was compared with the levels found in the presence of various fetal malformations--Rh-isoimmunization, maternal diabetes, chromosomal anomalies, and fetal death in utero. The findings and their implications are discussed.

Amniotic Fluid↗
PubMed1978

[Determination of the gestation period by means of ultrasound. Cephalometry in twins (author's transl)].

In 147 twin pregnancies, the biparietal diameter of the skull was determined by means of an ultrasound B-scan method. 574 individual measurements were evaluated. It was found that a marked flattening of the growth curve sets in from the 30th week of pregnancy, compared with single births. The difference amounted to 6 mm in the 40th week of pregnancy. The wavy shape of the mean value curve in twins up to the 30th week of pregnancy, appears particularly remarkable. The reason for this phenomenon could be seen in high-grade placental insufficiency causing spontaneous abortion or premature delivery. Accordingly, an increased incidence of abortion was recorded in the 21st and 25th week, as well as a peak in premature births in the 29th and 30th week of pregnancy. The heads of the twins were not equal in size. The average difference of the diameters of the skull was 6 mm.

Abortion, Spontaneous↗
PubMed1977

[The excretion of chorionic gonadetropin in 55 cases of hydatidiform mole (author's transl)].

In 55 cases of hydatidiform mole, 323 quantitative assays of chorionic gonadotropin were evaluated. In cases of molar degeneration the mean HCG excretion was 20% below normal. In cases of hydatidiform mole and invasive mole the mean HCG excretion was significantly above normal. Many cases of hydatidiform mole and all cases of invasive mole showed a repeat rise of the HCG titres after curettage. The pattern of HCG excretion in hydatidiform mole is shown in diagrams.

Chorionic Gonadotropin↗