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Biomedical subjects

W Lindemann

Publications and source records attributed to W Lindemann.

At least 19 recordsLinked to original sources
PubMed1995

[Laparoscopic resections in Crohn disease].

39 patients with Crohn's disease underwent laparoscopic bowel resections during January 1993 to May 1995 (16 female, 23 male, with an average age of 33 years). The duration of the disease ranged from one to 18 years. 21 of the 39 patients were under steroid therapy at the time of operation. Seven patients have had ileocaecal resection for Crohn's disease. The operative technique is laparoscopically assisted. We performed: small bowel resections (8), ileocaecal resections (16), hemicolectomies (11), subtotal colectomies (2), colectomies (2). Operative time ranged from 90 to 280 min for ileocaecal resections and from 330 to 420 min for colectomies. Intraoperative complications were not encountered. Postoperatively one patient developed a subhepatic abscess which was drained under sonographic guidance on day 6. One patient was reoperated for a different disease on postoperative day 2. Two patients had fever till day 9 and 13 without clinical relevance. Two patients had delayed incision site healing. Postoperative clinical stay was 11 days. The main benefit for the patients was early mobilisation due to reduced pain. Patients experienced the small abdominal incision as a ray of hope in their chronic disease.

Adolescent↗
PubMed1995

[Intersphincteric rectum resection with colosphincter pouch].

In rectal cancer the emphasis has moved towards sphincter saving resection. Tumor site and penetration depth decide the operative technique in low rectal cancer. 1) Resection at the upper confinement of the anal canal. 2) Intersphincteric resection at the level of the dentate line. Reconstruction is achieved by a colonic J-pouch. From 1991 to 1994 we operated on 35 patients with an average age of 58.1 years. An intersphincteric resection was performed in 11 patients whose tumor was situated between 0 and 2 cm upwards the dentate line. 24 cancers were situated between 2 and 6 cm of the dentate line and were resected at the upper confinement of the anal canal with a linear stapler. Tumor penetration depth was determined endosonographically (ES). Four patients had tumor stage ES T1, 13 ES T2 and 18 ES T3. A J-pouch of 7-9 cm size was sutured (11) or stapled (24) to the anal canal. In 10 patients who underwent intersphincteric resection the pre- and post-operative anal pressures were determined. We did not encounter major complications. In three patients a leakage at the colonal anastomosis postponed closure of the diverting colostomy. We had no anastomotic recurrence but one pelvic side recurrence. Four patients developed liver metastases; in one case resectable. Postoperative anal sphincter pressure was reduced in all cases but clinically relevant only in one. This patient has frequent major soiling, three patients have occasional minor leak. Two patients are incontinent of gas, 26 are perfect continent. One patient has bowel movements every two days, 15 one per day, 12 two per day and 3 three per day.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1994

[A hemolytic crisis with liver failure as the first manifestation of Wilson's disease].

An 18-year-old woman developed an acute haemolytic anaemia, acute transient renal failure and progressive hepatic failure. Coeruloplasmin and serum copper concentration were normal; a Kayser-Fleischer ring and any neurological symptoms were absent initially. Liver biopsy was contraindicated because of increased bleeding tendency. Wilson's disease was diagnosed only after the acute renal failure had regressed, on the basis of the urinary copper excretion (2890 micrograms/d, rising to 7330 micrograms/d after D-penicillamine administration). Progressive liver failure required transplantation. After it the patient quickly recovered and is now, two years later, free of disease. -This case demonstrates that Wilson's disease may be difficult to diagnose at the time of initial acute manifestation. But it can be recognized early from the pathognomonic low alkaline phosphatase and by calculation of free serum copper.

Acute Disease↗
PubMed1994

[The colo-anal pouch: indications, function and results].

Low anterior resection of rectal cancer with preservation of the anal sphincter has comparable recurrence and survival rates when compared to abdominoperineal excision. Stool frequency and leakage rates are high after coloanal anastomosis. The colonic J-pouch improves function. Endosonographic tumor stages ES T1 and ES T2 for cancer in the distal third rectum and ES T3 tumors in die middle third rectum are indications for rectal resection with preservation of the sphincter and reconstruction with the colonic pouch. In 33 patients the technique was safe, with no deaths and no reoperation. Three diverting colostomies are not yet closed. 25 patients are perfect continent, two are incontinent for gas, three have minor and one patient major incontinence. Only one patient has more than three bowel movements in 24 hrs. For selected cancers of the distal half of the rectum total resection with preservation of the anal sphincter is a safe operation. Good function is provided by the colon J-pouch.

Adult↗
PubMed1992

[Fluorouracil as monotherapy or combined with folinic acid in the treatment of metastasizing colorectal carcinoma].

In a prospective randomized multicentre trial 139 patients with metastatic colorectal carcinoma (70 men, 69 women; age 35-81 years) were given palliative treatment with fluorouracil (400 mg/m2 daily for 5 days) alone or combined with folic acid (100 mg/m2 before each dose of fluorouracil). Both groups were comparable in respect of age, sex, Karnofsky index and number of localisations of metastases. The criterion for starting the treatment was progression of the malignancy or clinical symptoms caused by the tumour. Resulting remission rates (fluorouracil monotherapy vs combination with folic acid) were: complete or partial remission, 9 vs 16%; arrest of tumour growth, 20 vs 60%; progression 71 vs 24%. Peripheral side effects, such as stomatitis and diarrhoea, were similarly frequent with the two treatment regimens and reasonably tolerable. Median survival time for the fluorouracil monotherapy was 7.24 months from onset of treatment, and 9.1 months from the time that any metastases were diagnosed. The combination treatment with folic acid achieved a significantly longer median survival time (P less than 0.0001), 14.98 months from treatment onset and 16.3 months from metastasis diagnosis. The higher rate of response and the significantly prolonged survival time signify an improvement of the therapeutic profile of fluorouracil by addition of folic acid in the palliative therapy of colorectal carcinomas.

Adult↗
PubMed1992

[Aneurysms of the hepatic artery].

A series of seven cases of hepatic artery aneurysms is reported. Guidelines for diagnosis and therapeutic approach to this rare disease are specified based on our own results and on the work of other authors. Because of high mortality, hepatic and biliary complications in cases of ruptured hepatic aneurysms elective vascular surgery is recommended in symptomatic and asymptomatic patients. In cases of intrahepatic localization percutaneous catheter embolization may be the method of choice except for some cases of false aneurysms in transplanted livers.

Anastomosis, Surgical↗
PubMed1991

Different systems for iron supply of Salmonella typhimurium and Escherichia coli wild strains as tool for typing.

Hitherto the siderophore-pattern analysis included bioassays to detect enterobactin,aerobactin and other siderophores of Enterobacteriaceae. In addition, 2,3-dihydroxybenzoic acid, the precursor of enterobactin, and new hydroxamate siderophores could be examined by means of two new Salmonella mutants as indicator strains. In this manner the siderophore pattern analysis extends its discriminating ability. Among 167 Salmonella typhimurium strains tested, we detected 5 siderophore patterns. 6 siderophore patterns could be detected among a total of 204 E. coli strains. Using siderophore pattern analysis for clinical-epidemiological and ecological purposes appropriate technical methods can be recommended.

Biological Assay↗
PubMed1990

[Quality of the marginal seal of spark-eroded crowns using different modes of preparation].

Six acrylic tooth stumps were prepared for an evaluation of the marginal quality of crowns produced by spark erosion. Four different methods were used for preparation of the crown margins. Each stump had two different margin preparations. The crowns were fabricated with the aid of spark erosion. Serrated sections were then made for an analysis of marginal defects. The results have shown that the mean size of marginal openings is highly dependent on the preparation method used.

Acrylic Resins↗
PubMed1989

[Apical root pins of high-karat gold alloys for resected roots].

Following earlier studies on corrosion of silver pins in the root canal experience will be presented with the use of high-karat gold pins for apical closure of root amputations. The commercially available standardized Ackermann silver pins were replaced by high-karat gold pins of similar Vicker hardness and inserted in 218 patients with 264 root amputations since 1986. A clinical and radiological follow-up demonstrated a success rate of over 90%.

Dental Pins↗
PubMed1986

Spatial mapping of intracranial auditory events for various degrees of interaural coherence.

The broadening and splitting of auditory events in dichotic listening conditions with various degrees of interaural coherence are discussed. By using a psychoacoustical mapping method, it has been possible to observe broadening and splitting for a wide range of stimuli, including broadband pink noise as well as bandpass noises with different relative bandwidths and center frequencies. The spatial extents of the auditory events decrease with increasing center frequencies for bandpass stimuli of constant relative bandwidth. The number of partial events for bandpass stimuli decreases with increasing degrees of interaural coherence. These results are, for example, of interest with respect to auditory spaciousness in architectural acoustics.

Attention↗
PubMed1986

Auditory spaciousness: some further psychoacoustic analyses.

Psychoacoustic investigations have confirmed the known high correlation of auditory spaciousness and preference in concert-hall types of sound fields. Further, they have provided exploratory results which gave rise to the following interpretations: Auditory spaciousness is a multidimensional perceptual attribute, predominantly caused by early lateral reflections. Low-frequency reverberation may also contribute slightly, but is sensitive with respect to individual taste. All spectral components of early lateral reflections contribute to spaciousness. Spectral restriction of the reflections leads to less favorable judgments. Early lateral reflections which do not contain spectral components above about 3 kHz mainly create image expansion in the front-back direction, thus adding to the sense of envelopment of the listener. If components above about 3 kHz are present, image broadening is prominent. By means of a model of binaural signal processing which takes interaural arrival-time differences as well as interaural level differences into account, a quasiobjective measure of auditory spaciousness can be derived.

Adult↗
PubMed1986

Extension of a binaural cross-correlation model by contralateral inhibition. I. Simulation of lateralization for stationary signals.

Running interaural cross correlation is a basic assumption to model the performance of the binaural auditory system. Although this concept is particularly suited to simulate psychoacoustic localization phenomena, there exist some localization effects which cannot be explained by pure cross correlation. In this paper a model of interaural cross correlation is extended by a "contralateral-inhibition mechanism" and by "monaural detectors" in order to simulate a wide range of psychoacoustic lateralization data. The extended model explains lateralization of pure tones with interaural time differences as well as with interaural level differences. Multiple images are predicted for tones with characteristic combinations of interaural signal parameters and for noise signals with different degrees of interaural cross correlation. The model is also capable of simulating dynamic lateralization phenomena, such as the "law of the first wave front" which is dealt with in a companion paper [Lindemann, J. Acoust. Soc. Am. 80, 1623-1630 (1986)]. The present paper is restricted to a comparison of the model predictions for stationary signals with the results of dichotic listening experiments.

Auditory Perception↗