Treatment of hyperparathyroidism.
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Biomedical subjects
Publications and source records attributed to W Lineaweaver.
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A technique of measuring directed and random migration of mouse neutrophils was developed to study these neutrophil functions in a standardized small animal population into which specific variables could be introduced. Values in healthy animals were highly reproducible; variations in random and directed migration did not exceed 9%. Mouse neutrophils had significant impairment of directed and random migration at 3, 5, and 8 days after infection with cytomegalovirus. Technical reproducibility and the ability to reflect a disease process make this model a promising one for the laboratory study of neutrophil migration.
Computed tomographic demonstration of single calcified parathyroid glands in two patients corresponded to operative findings of a calcified carcinoma and a calcified adenoma. The CT demonstration of a calcified parathyroid gland should suggest carcinoma, and the operative approach should be planned to permit an en bloc resection.
An intrahepatic hepatic artery aneurysm with massive hemobilia was successfully obliterated by intraoperative ligation of a branch of the right hepatic artery. Subsequent CT studies showed a large area of intrahepatic necrosis that was well tolerated, but was eventually manifested as a biliary-cutaneous fistula. Our patient's benign course argues that management of segmental hepatic necrosis can be tailored to the clinical response.
After CMV infection, significant reduction in directed neutrophil migration persisted through 21 days; reduction of random migration persisted through 14 days. The duration of these defects coincide with other immune derangements and increased susceptibility to lethal bacterial infections.
Among 23 cases of obscure masses in the abdominal wall or groin examined by ultrasound, 91% had clinical confirmation of the ultrasonic findings, and in 39% of the cases, unsuspected conditions were diagnosed. All of the unconfirmed findings occurred through inability to distinguish inguinal adenopathy from inguinal abscesses.
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Twelve patients with profound gastric atony were taught to administer their own tube jejunostomy bolus feedings and, when necessary, to manage their gastric secretions by connecting their gastrostomy and jejunostomy tubes. These techniques allowed 11 of 12 patients to obtain reasonable nutrient intake and eight of the 12 to successfully reinfuse retained gastric secretions; alleviating the need for intravenous fluid replacement and expediting hospital discharge. Seven patients were able to resume some oral intake at home after resolution of their gastric atony. In the sufficiently motivated patient with gastric atony from multiple causes, these techniques provide alternatives to indefinite hospitalization with cumbersome and expensive intravenous hyperalimentation or constant infusion enteral alimentation.