PubMed Health⌕ Search

Biomedical subjects

W M Brady

Publications and source records attributed to W M Brady.

5 recordsLinked to original sources
PubMed1998

Gastroesophageal reflux disease.

Gastroesophageal reflux disease is a common disorder in which irritant gastric contents enter the esophagus, most commonly via transient lower esophageal sphincter relaxation. The diagnosis of gastroesophageal reflux disease may be made on clinical grounds alone or may be confirmed with studies including esophagogastroduodenoscopy or ambulatory pH monitoring. There are a number of different medications to treat reflux disease, including histamine-2 receptor antagonists, promotility agents and the proton pump inhibitors. Reflux disease often requires chronic maintenance therapy.

Journal Article↗
PubMed1997

Controversies in diagnosis and treatment of hepatitis C. Which patients benefit most from therapy?

Hepatitis C virus has recently been identified as an important cause of morbidity and mortality worldwide. Acute hepatitis C infection is clinically indistinguishable from other types of viral hepatitis but is much more likely to become chronic. Chronic hepatitis C is a significant cause of cirrhosis and hepatocellular carcinoma. While modes of transmission, diagnosis, and treatment are currently controversial, Dr Brady discusses some approaches for dealing with this emerging problem.

Antiviral Agents↗
PubMed1996

Gastroesophageal reflux disease. The long and the short of therapeutic options.

Gastroesophageal reflux disease (GERD) is a common and treatable condition. Initial therapy includes lifestyle modifications, avoidance of certain medications, and use of antacids, alginic acid preparations, and over-the-counter histamine2 (H2) receptor antagonists. Escalation of therapy for acute disease relies primarily on H2 receptor antagonists given in conventional dosages. Although H2 receptor antagonists remain the cornerstone of therapy, sucralfate and promotility agents, especially cisapride, may offer alternatives. Most cases of GERD that are resistant to these therapies can be reliably healed with proton pump inhibitors (PPIs). Patients whose GERD is healed with one of the aforementioned agents often relapse unless they receive further therapy. For patients with mild disease, H2 receptor antagonists, cisapride, or a combination of the two may prevent recurrent symptoms. In severe disease, PPIs are the agents of first choice, but concerns about the safety of long-term use must be considered. In selected patients, surgery offers an option for long-term control of GERD. With present surgical techniques, symptom relief can be obtained with little risk of complications.

Anti-Ulcer Agents↗