PubMed Health⌕ Search

Biomedical subjects

W M Budde

Publications and source records attributed to W M Budde.

At least 55 records · Page 3Linked to original sources
PubMed1999

[Cataract extraction combined with trans-pupillary silicone oil drainage by planned posterior capsulorhexis].

BACKGROUND: A cataract is frequently observed after pars plana vitrectomy with silicone oil endotamponade. PATIENTS AND METHODS: Forty-three consecutive patients underwent cataract surgery combined with transpupillary removal of silicone oil. After phacoemulsification of the lens material through a sclerocorneal tunnel incision, a planned posterior capsulorhexis with a diameter of 3-4 mm was performed. By injecting saline through the capsulorhexis into the vitreous cavity, the silicone oil was rinsed out. Widening of the sclerocorneal tunnel facilitated the drainage of the silicone oil through the pupil and tunnel. After ophthalmoscopic evaluation of the fundus, a plano-convex PMMA posterior chamber lens was implanted into the capsular bag or ciliary sulcus, and the corneoscleral tunnel was closed by a 10-0 nylon suture. RESULTS: Depending on the underlying retinal disease the visual acuity improved in some eyes. Silicone oil bubbles left behind in the vitreous cavity were smaller than 0.5 mm in diameter. Persisting corneal decompensation or a clinically detectable cystoid macular edema related to cataract surgery did not occur. Due to the posterior capsulorhexis, secondary cataract did not develop postoperatively. Small postoperative vitreous hemorrhages resolved during the first three post-operative days. Retinal detachment recurred in 11 eyes (11/42 or 26.2%). In one eye, dislocation of the pseudophacos occurred which had to be corrected surgically. Since the pars plana region remained untouched, direct retinal lesions in the periphery of the fundus or marked vitreous hemorrhages were not encountered. CONCLUSIONS: Silicone oil removal can be combined with cataract surgery with transpupillary drainage of the silicone oil.

Adult↗
PubMed1999

[Titration of intraoperative anesthesia and postoperative analgesia].

PURPOSE: To evaluate a temporary retrobulbar catheter for local anesthesia in intraocular surgery and for postoperative analgesia after intraocular surgery. PATIENTS AND METHODS: The study included 40 patients undergoing pars-plana vitrectomy (n = 24) or cyclocryocoagulation (n = 16). After a retrobulbar injection through a 23 G needle, a commercially available 28 G flexible catheter was inserted through the needle. As soon as the patients complained about pain during or up to 24 hours after surgery, local anesthetics were injected through the catheter. RESULTS: Repetitive injections of anesthetics were necessary in 13 patients during pars plana vitrectomy. Starting about 2 hours after surgery, 13 patients after pars-plana vitrectomy and all patients who had undergone cyclocryocoagulation received up to 6 re-injections (every 1.5-5 hours). After all re-injections, the patients became pain-free within two minutes. The catheter was removed after 24 hours. CONCLUSIONS: The results suggest that a temporary insertion of a catheter into the retrobulbar space allows repetitive application of local anesthetics thus leading to a titrable local anesthesia and postoperative analgesia in intraocular surgery.

Anesthesia, Local↗
PubMed1999

[Exit of the retinal central vascular trunk and extent of para-papillary atrophy].

PURPOSE: To evaluate whether the position of the central retinal vessel trunk exit on the lamina cribrosa spatially correlates with the location of parapapillary atrophy in glaucoma. METHODS: Color stereo optic disc photographs of 79 patients with primary or secondary open-angle glaucoma and 53 normal subjects were morphometrically evaluated. We determined the position of the central retinal vessel trunk exit on the lamina cribrosa surface and measured the area of parapapillary atrophy in four 90 degrees quadrants. RESULTS: After correction for normal values, the beta zone area of parapapillary atrophy in the glaucoma eyes was significantly larger, when measured in the disc quadrant most distant to the central retinal vessel trunk exit than as if measured in the quadrant containing the vessel trunk exit. CONCLUSIONS: Position of the central retinal vessel trunk exit on the lamina cribrosa influences the location of parapapillary atrophy in glaucoma. The longer the distance to the central retinal vessel trunk exit, the more enlarged is parapapillary atrophy.

Adult↗
PubMed1999

Early versus late removal of retained intraocular foreign bodies.

PURPOSE: To compare early versus late removal of retained intraocular foreign bodies (IOFBs). METHODS: Sixty-two patients presenting with open-globe injuries due to lacerations by retained IOFBs were consecutively operated by the same surgeon between 1989 and 1997. Minimum follow-up was more than 3 months. In 43 patients, the IOFB was removed during the first 24 hours after the accident. In 19 patients, in whom the wound had been closed during a first operation, the IOFB was removed later than 24 hours after the accident. The study groups did not vary significantly in age, refractive error, type and size of IOFB, prevalence of traumatic cataract and peripheral or central corneal lacerations, or visual acuity on presentation. RESULTS: Endophthalmitis developed significantly more often in the late intervention group than in the early intervention group (3/19 [15.7%] versus 1/43 [2.3%]; P = 0.0467; chi-square test). Considering patients with retinal lesions due to the IOFB (n = 47), proliferative vitreoretinopathy occurred significantly more often in the late intervention group than in the early intervention group (6/13 [46.2%] versus 6/34 [17.6%]; P = 0.0449). CONCLUSIONS: Confirming previous reports, the results of the current study suggest that removing retained IOFBs within the first 24 hours after the injury may in some clinical situations reduce the risks of infectious endophthalmitis and proliferative vitreoretinopathy.

Adolescent↗
PubMed1999

Temporal contrast sensitivity with peripheral and central stimulation in glaucoma diagnosis.

AIMS: To evaluate temporal contrast sensitivity with full field, peripheral, and central stimulation and to determine the most sensitive corresponding retinal area for glaucoma damage. METHODS: Temporal contrast sensitivity was determined either with a full field, a peripheral annular area from 30 degrees to 90 degrees, or a central area from 0 degree to 30 degrees at a frequency of 37.1 Hz. 232 eyes of 232 subjects were included. They were classified into four groups: eyes with ocular hypertension (OHT, n = 54), "preperimetric" glaucomas (n = 73) with glaucomatous optic disc abnormalities but no visual field loss, "perimetric" glaucomas (n = 53) with visual field loss, and 52 normals. RESULTS: In all four groups, temporal contrast sensitivity was almost equal with full field and peripheral, but significantly higher than with central stimulation (p < 0.001). With regard to the diagnostic power of the three different stimulus areas, OHTs and glaucomas were found to be best discriminated from normals by peripheral stimulation. CONCLUSIONS: According to these results, temporal contrast sensitivity seems to be determined by peripheral retinal areas. As the diagnostic power of the three different stimulus areas was best with the peripheral stimulation, this condition should be used for early glaucoma diagnosis.

Adult↗
PubMed1999

Preperimetric glaucoma diagnosis by confocal scanning laser tomography of the optic disc.

AIM: To evaluate the ability of confocal scanning laser tomography of the optic nerve head to detect glaucomatous optic nerve damage in ocular hypertensive eyes without visual field defects. METHODS: The study included 50 normal subjects, 61 glaucoma patients with glaucomatous changes in the optic disc and visual field, and 102 "preperimetric" patients with increased intraocular pressure, normal visual fields, and glaucomatous appearance of the optic disc as evaluated on colour stereo optic disc photographs. For all individuals, confocal scanning laser tomographs of the optic nerve head were taken using the Heidelberg retina tomograph (HRT; software 2.01). RESULTS: Almost all investigated HRT variables varied significantly (p < 0.05) between the normal eyes and preperimetric glaucoma eyes with pronounced overlap between the two study groups. Corresponding to the overlap, sensitivity and specificity values were relatively low when HRT variables were taken to differentiate between normal and preperimetric glaucoma eyes. At a given specificity of 95% highest sensitivities were found for the variables "rim area in the superior disc sector" (24.8%), "nerve fibre layer thickness in the inferior disc sector" (26.5%), and "rim volume in the superior disc sector" (25.5%). A multivariate approach increased sensitivity to 42.2% at a given specificity of 95%. For the glaucoma group highest sensitivity values were reached by rim volume in the superior disc sector (73.8%) and rim area (72.1%); the multivariate approach reached 83.6%. CONCLUSIONS: Owing to pronounced overlapping between the groups, confocal scanning laser tomography of the optic nerve head has relatively low diagnostic power to differentiate between normal eyes and preperimetric glaucoma eyes. One of the reasons may be the biological interindividual variability of quantitative optic disc variables.

Adult↗
PubMed1999

Optic cup deepening spatially correlated with optic nerve damage in focal normal-pressure glaucoma.

PURPOSE: To evaluate whether deepening of the optic cup in patients with focal normal-pressure glaucoma is correlated with the location of most marked loss of neuroretinal rim and visual field. METHODS: Using morphometric evaluation of color stereo optic disc photographs of 102 eyes of 65 patients with focal normal-pressure glaucoma, the superior half of the optic disc was compared with the inferior half. RESULTS: In eyes in which the optic cup was deepest in the inferior half of the disc, the most pronounced rim loss was located inferiorly significantly more often than superiorly, and the most marked visual field loss was located superiorly significantly more often than inferiorly. In eyes in which the optic cup was deepest in the superior half of the disc, the most pronounced rim loss was located superiorly significantly more often than inferiorly, and the most marked visual field loss was located inferiorly significantly more often than superiorly. Correspondingly, in eyes in which the most marked rim loss was located inferiorly, the deepest optic cup part was located inferiorly significantly more often than superiorly, and vice versa. CONCLUSION: In focal normal-pressure glaucoma, location of the most marked deepening of the optic cup is spatially correlated with the location of most pronounced neuroretinal rim loss and visual field damage. Because high-pressure glaucoma is typically associated with optic cup deepening and vascular optic nerve damage is associated with optic cup flattening, the spatial correlation between focal optic nerve damage and focal cup deepening may suggest the presence of a pathogenetic aspect in both high-pressure glaucoma and focal normal-pressure glaucoma.

Adult↗
PubMed1999

Polarimetric measurement of retinal nerve fiber layer thickness in glaucoma diagnosis.

PURPOSE: To evaluate reliability and diagnostic value of polarimetric measurements of the retinal nerve fiber layer (RNFL) thickness in the diagnosis of glaucoma. METHODS: The study included 81 eyes with perimetric glaucoma with glaucomatous changes of the optic disc and visual field defects; 52 eyes with preperimetric glaucoma with glaucomatous optic disc abnormalities and normal achromatic visual fields; and 70 normal eyes. For determination of reliability, four examiners repeated polarimetric measurements five times in ten normal subjects. RESULTS: The polarimetric variables were significantly correlated with increasing mean visual field defect and decreasing neuroretinal rim area. In correlation analyses with visual field defects, correlation coefficients were highest for the variable "superior/nasal ratio" and "the Number," a variable calculated by the neural network of the device. In correlations with neuroretinal rim area, correlation coefficients were highest for measurements of the inferior nerve fiber layer thickness. The preperimetric glaucoma group and the control group differed significantly in the variables "superior/nasal ratio" and "the Number" and, to a smaller degree, in the variables "superior/temporal ratio" and "superior/inferior ratio." The Number variable had a sensitivity of 82% and 58% at a predefined specificity of 80% in separating perimetric glaucoma patients and preperimetric glaucoma patients, respectively, from control subjects. Reproducibility of the polarimetric measurements ranged between 70% and 89%. CONCLUSION: Polarimetric measurements of the RNFL thickness can detect glaucomatous optic nerve damage in patients with visual field loss, and in some patients with preperimetric glaucomatous optic nerve damage. Considering the fast performance, easy handling, and low maintenance costs, RNFL polarimetry may be helpful in glaucoma diagnosis.

Adult↗
PubMed1998

Juvenile open angle glaucoma: fine mapping of the TIGR gene to 1q24.3-q25.2 and mutation analysis.

Autosomal dominant juvenile open angle glaucoma (JOAG) is an early-onset form of primary open angle glaucoma (POAG), which has been linked to chromosome 1q21-q31. Recently, mutations in the trabecular meshwork inducible glucocorticoid response gene (TIGR), one of the candidate genes mapped in this region, were identified in glaucoma patients of several families. We screened for mutations of the TIGR gene in two German families with JOAG and in 100 unselected sporadic cases of POAG. In the first family we identified a Pro370Leu mutation and in the second family a Gly367Arg mutation cosegregating with the glaucoma phenotype. No pathogenic mutation was found in 100 sporadic cases but a Tyr347Tyr polymorphism was found in two patients. Furthermore, fluorescence in situ hybridization (FISH) analysis was used to map a TIGR-specific yeast artificial chromosome to 1q24.3-q25.2.

Adolescent↗
PubMed1998

Cataract surgery combined with transpupillary silicone oil removal through planned posterior capsulotomy.

OBJECTIVE: The purpose of the study was to evaluate transpupillary removal of silicone oil combined with cataract surgery in patients after pars plana vitrectomy. DESIGN: A prospective case-control study. PARTICIPANTS: Fifty consecutive patients underwent cataract surgery combined with removal of silicone oil, which had served as intraocular tamponade after pars plana vitrectomy. In 28 patients, silicone oil was removed through a planned posterior capsulotomy, and in 22 patients, silicone oil was removed through pars plana sclerotomies. All patients were operated on by the same surgeon. INTERVENTIONS: Pars plana vitrectomy, cataract surgery, and silicone oil removal were performed. MAIN OUTCOME MEASURES: Frequencies of retinal redetachment, secondary cataract, cystoid macular edema, and vitreous hemorrhage; visual acuity; intraocular pressure; and duration of surgery and visual rehabilitation were measured. RESULTS: Frequencies of postoperative vitreous hemorrhage (1 of 28 [4%] vs. 10 of 22 [45%]) and secondary cataract (0 of 28 vs. 6 of 22 [27%]) were significantly lower (P < 0.05; chi-square test), and duration of surgery and visual rehabilitation were significantly shorter (P < 0.01) for patients with transpupillary silicone oil removal than for patients with drainage of silicone oil through pars plana sclerotomies. Rate of retinal redetachment (4 of 28 [14%] vs. 4 of 22 [18%]), time of retinal redetachment (36 +/- 32 postoperative days vs. 54 +/- 65 days), frequency of dislocated intraocular lenses (1 of 28 vs. 0 of 22), and postoperative visual acuity did not vary significantly between the two groups. Persisting comeal endothelial decompensation and clinically significant cystoid macular edema due to cataract surgery were not observed in any patient. CONCLUSIONS: Silicone oil removal can be combined with cataract surgery. In view of a decreased frequency of postoperative vitreous hemorrhage, reduced rate of secondary cataract, and shorter duration of surgery and visual rehabilitation, transpupillary drainage of silicone oil through a planned posterior capsulotomy compares favorably with removal of silicone oil through pars plana sclerotomies. Retinal redetachment usually occurs within the first 3 postoperative months.

Adolescent↗
PubMed1998

[No effect of diabetes mellitus on the morphology of the optic nerve papilla in primary open angle glaucoma].

PURPOSE: To evaluate the effect of diabetes mellitus on the optic disc morphology in primary open-angle glaucoma. PATIENTS AND METHODS: Within a group of 364 patients with primary open-angle glaucoma, a subgroup of 52 patients with diabetes mellitus and a second subgroup of 312 patients without diabetes mellitus were compared with each other. Eyes with proliferative diabetic retinopathy had been excluded. Both subgroups were matched for age, gender, and refractive error. The optic disc was morphometrically evaluated using stereo disc photographs. RESULTS: The two subgroups did not vary significantly (p > 0.10) in mean size of the optic disc, neuroretinal rim and zones Alpha and Beta of the parapapillary chorioretinal atrophy, and frequencies of disc hemorrhages. CONCLUSIONS: Patients with or without diabetes mellitus do not differ significantly in the morphology of the optic disc. One may conclude that diabetes mellitus does not markedly influence planimetric assessed optic disc damage in patients with primary open-angle glaucoma, if eyes with proliferative diabetic retinopathy have been excluded.

Adult↗
PubMed1998

[Chalcosis oculi].

PURPOSE: To report on a patient including measurements of retinal changes in ocular chalcosis. PATIENT AND METHODS: After having suffered an open-globe injury presumably due to a small foreign body after a grenade explosion, a 30-year-old man presented six years later with ocular chalcosis including sunflower cataract, a multitude of tiny brownish particles in the anterior vitreous, a fibrillar degeneration of the posterior vitreous and brilliant patches overriding the foveal region. The patches were measured by confocal scanning laser tomography (HRT) and optical coherence tomography (OCT). RESULTS: Besides an acquired cyandyschromatopsia, psychophysical and electrophysiologic tests were unremarkable. Vision was 20/20. The central patches measured 200 to 700 microns in diameter (HRT) and 150 to 200 microns in height above the inner retinal surface (HRT and OCT). DISCUSSION: With exception of a Kayser-Fleischer ring of the cornea the patient presents all morphologic signs of ocular chalcosis. Although the observed patches on the central retina in ocular chalcosis are described in the literature, their nature is not known.

Adult↗
PubMed1998

[Acute preretinal hemorrhage before life threatening complications of subarachnoid hemorrhage].

BACKGROUND: To report on a patient with acute preretinal and intraretinal bleedings as first clinical signs of a life-threatening subarachnoid hemorrhage. PATIENT: A 36-year-old, so far healthy woman complained of decreased vision, which had started eight hours before. She presented herself in good general condition. Ophthalmoscopic evaluation showed intraretinal hemorrhages in both eyes and a preretinal hemorrhage in the left eye. During the examination, the patient fainted and suffered generalized seizure. Cranial computed tomography revealed a subarachnoid hemorrhage originating from an internal carotid artery aneurysm. CONCLUSION: Acute intraretinal and preretinal bleedings in apparently healthy patients can be precursors of eventually life-threatening complications of subarachnoid hemorrhages.

Adult↗
PubMed1998

Neuroretinal rim width ratios in morphological glaucoma diagnosis.

AIMS: To evaluate the inferior to temporal neuroretinal rim width ratio and superior to temporal rim width ratio as measures of rim shape for diagnosis of glaucoma. METHODS: Colour stereo optic disc photographs of 527 normal subjects, 100 ocular hypertensive individuals with normal visual fields, and 202 open angle glaucoma patients with a mean perimetric defect of less than 10 dB were morphometrically evaluated. Eyes with an optic cup area of < 0.2 mm2 were excluded. RESULTS: In the normal subjects, inferior to temporal rim width ratio (1.67 (SD 0.53)) was significantly (p < 0.0001) higher than superior to temporal rim width ratio (1.56 (0.49)). Both ratios were significantly (p < 0.0001) higher the more vertically the optic disc was configured. In the normal eyes, both ratios were statistically independent of disc size, rim area, refractive error, age, and sex. With the differences being more marked for the inferior to temporal ratio than for the superior to temporal ratio, both rim width ratios were significantly (p < 0.005) lower in the ocular hypertensive group than in the normal group. Despite the high significance of the differences, diagnostic power of the inferior ratio and the superior ratio was 59% and 58%, respectively, indicating a marked overlap between the groups. CONCLUSIONS: Abnormally low inferior to temporal and superior to temporal rim width ratios can indicate glaucomatous optic nerve damage in some ocular hypertensive eyes. Being independent of optic disc size and ocular magnification, the rim width ratios may be taken as one among other variables for the ophthalmoscopic optic disc evaluation, taking into account, however, a pronounced overlap between normal eyes and ocular hypertensive eyes.

Adolescent↗
PubMed1998

Optic disc morphology in pigmentary glaucoma.

AIM: To evaluate the morphology of the optic nerve head in eyes with pigmentary glaucoma. METHODS: Colour stereo optic disc photographs of 62 patients with pigmentary glaucoma and 566 patients with primary open angle glaucoma were morphometrically evaluated. By prestudy selection, mean visual field defect and neuroretinal rim area were not significantly different between the two groups (p = 0.89 and p = 0.45). RESULTS: The pigmentary glaucoma group did not vary significantly (p > 0.10) from the primary open angle glaucoma group in size and shape of the optic disc, configuration of neuroretinal rim, depth of optic cup, area of alpha zone of parapapillary atrophy, diameter of retinal vessels at the disc border, and frequency of disc haemorrhages and localised retinal nerve fibre layer defects. The beta zone of parapapillary atrophy was slightly, but not statistically significantly (p = 0.06), smaller in the pigmentary glaucoma group. The mean maximal intraocular pressure and mean intraocular pressure amplitude were significantly (p < 0.001) higher in the pigmentary glaucoma group. CONCLUSIONS: In contrast with the characteristic morphology of the anterior segment and despite significantly higher intraocular pressure peaks and a larger pressure amplitude, eyes with pigmentary glaucoma compared with eyes with primary open angle glaucoma do not show a pathognomonic morphology of the optic disc and retinal nerve fibre layer. The slightly smaller beta zone of parapapillary atrophy may correspond to higher intraocular pressure in pigmentary glaucoma.

Adult↗