PubMed Health⌕ Search

Biomedical subjects

W M Castle

Publications and source records attributed to W M Castle.

17 recordsLinked to original sources
PubMed1992

Safety of ondansetron.

Ondansetron is a novel 5-HT3 receptor antagonist used for the treatment of cytotoxic-induced emesis and postoperative nausea and vomiting. Safety data from volunteer studies, non-emesis development studies, studies in the treatment of cytotoxic-induced emesis and postoperative nausea and vomiting, and spontaneous case reports, all indicate that ondansetron is well tolerated and has an excellent safety profile. There are no known interactions of ondansetron with other drugs, and no interference with postoperative recovery.

Drug Tolerance↗
PubMed1978

Efficacy and acceptability of injectable medroxyprogesterone. A comparison of 3-monthly and 6-monthly regimens.

Five hundred Black Rhodesian women given injections of 150 mg Depo-Provera every 3 months (group A) and 500 women given an injection of 450 mg Depo-Provera every 6 months (group B) were reviewed after 6 months. Group B had a significantly lower rate of defaulters. There was no significant difference between the groups with regard to weight gain, systolic and diastolic blood pressure increase, overall abnormal bleeding patterns and complaints of side-effects. Among those women who reported abnormal bleeding patterns, significantly more in group B had amenorrhoea. There was no significant increase of prolonged bleeding in group B. Among those women who complained of side-effects, significantly more in group B complained of headaches and a bloated abdomen. No pregnancies occurred in either group. The increased annual cost of the 450 mg injections, which was the main reason for women not accepting this regimen, is outweighed by convenience and reduced travel costs. Depo-Provera 450 mg given by 6-monthly injection is well tolerated and effective, and appears to be even more satisfactory as regards continued acceptance than 150 mg given every 3 months.

Adult↗
PubMed1976

Measuring emotional stress in Africa: the difficulties involved and some results.

Two surveys of emotional stress were undertaken and the difficulties experienced in each survey are discussed. In the first survey, 3 sets of personality inventories, selected to identify the type A personality that is associated with the early onset of coronary heart disease, were completed by 95 men, aged from 40 to 50 years, who came from 4 groups: White Rhodesians, urban Blacks of high and low social status, and Blacks from a rural area. The same trend was shown by all 3 inventories, which indicates that type A behaviour is least common among Whites, becomes progressively more marked in Blacks of upper social class, then in Blacks of lower social status, and is greatest in Blacks living in a rural environment. The psychogalvanic response to emotional stress (fear) was used to assess autonomic lability in the first 3 groups.

Adult↗
PubMed1976

The pattern of acceptance by Blacks of family planning facilities in relation to socio-economic status.

Two factors which are said to increase the acceptability of family planning in a developing country are, firstly, the ready availability of the facilities and, secondly, the raising of the socio-economic level of the community. This survey reports the effects on family planning of increasing socio-economic status on the one hand, and of urbanisation without an associated increase in the socio-economic level on the other. It is concluded that, although socio-economic status has some effect on family planning, it has a greater effect on the survival rate of children. Urbanisation, however, with family planning facilities more readily available, exerts a stronger influence upon the acceptance of family planning than socio-economic status.

Adult↗
PubMed1976

Skull thickness of Black and White races.

The skull thickness in Black and White adults of both sexes was studied in Rhodesia by two methods. White women have the thickest, and White men the thinnest skulls. The skulls of women are thicker than those of men in both ethnic groups. The differences are shown to be statistically significant.

Adolescent↗