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Biomedical subjects

W M Chadduck

Publications and source records attributed to W M Chadduck.

At least 73 records · Page 4Linked to original sources

Acrylic stabilization of the cervical spine for neoplastic disease: evolution of a technique for vertebral body replacement.

The resection of collapsed cervical vertebral bodies affected by malignant lytic lesions often requires innovative methods for stabilization. Over the years, immediate stabilization of the cervical spine has been achieved with acrylic bridges, preformed metallic placement bodies, fibular strut grafts, and other aids. Because acrylic bonds poorly to adjacent bony structures, techniques to assure the adequate fixation of an acrylic bridge between resected vertebral bodies are needed. The possible progression of disease in adjacent bone prompts us to maximize the amount of internal fixation with rods or pins to assure stability. Lasting stability has become more important as the longevity of cancer patients has been increased by multimodality therapy. We report our technique for treating cancer patients with acrylic and pin fixation of the cervical spine after vertebral body excision by the anterior route. Certain modifications of the technique may have advantages over previously reported procedures. Our series of six cases demonstrates the evolution of a technique that allows relatively rapid and easy decompression of the cervical spinal cord and provides immediate stability of the cervical spine. Our indications and contraindications for this procedure are also discussed.

Acrylates↗

Multicentric glioma as a cause of multiple cerebral lesions.

Two new cases of multicentric glioblastoma are presented to re-emphasize the needs (a) to consider this diagnosis in patients with multiple intracerebral lesions suggesting metastases or abscesses and (b) to consider prompt biopsy of accessible lesions in these patients.

Brain↗

Familial gliomas: report of four families, with chromosome studies.

Four families having multiple family members with cerebral gliomas are presented. Genetic studies were done in some, but no chromosomal abnormalities were found in this group of patients or their families. The authors recommend that careful attention be given to the family history of all glioma patients and that more extensive genetic studies be done. The formation of a registry to report cases of familial gliomas is also suggested.

Adolescent↗

Cerebellar hemorrhage complicating cervical laminectomy.

A case of cerebellar hemorrhage complicating the postoperative course of a patient who had undergone a cervical laminectomy in the sitting position is presented. The drop in cerebrospinal fluid pressure accompanying the procedure is thought to have had some role in the development of the hemorrhage.

Cerebellar Diseases↗

Actinomycosis and lumbar disc disease.

The occurrence of isolated spinal lesions due to actinomycosis is rare. Nonetheless its presence in this case acts as another reminder of the variety of lesions that may present as a lumbar disc syndrome.

Actinomycosis↗

Cerebellar hemorrhage and CT scanning.

We have reviewed the clinical syndrome of acute cerebellar hemorrhage and have presented five cases of cerebellar hemorrhage of various types in which CT scanning was a significant aid in management. Recognizing the clinical syndrome, establishing the diagnosis rapidly by CT scanning, and avoiding potentially lethal diagnostic procedures, are all of crucial importance in expediting surgical treatment and improving the morbidity and mortality associated with this entity.

Adult↗

Empty sella syndrome secondary to intrasellar cyst in adolescence.

A 15-year-old boy had growth failure and failure of sexual development. The probable onset was at age 10. Endocrine studies showed hypopituitarism with deficiency of growth hormone and follicle-stimulating hormone, an abnormal response to metyrapone, and deficiency of thyroid function. Luteinizing hormone level was in the low-normal range. Posterior pituitary function was normal. Roentgenogram showed a large sella with some destruction of the posterior clinoids. Transsphenoidal exploration was carried out. The sella was empty except for a whitish membrane; no pituitary tissue was seen. The sella was packed with muscle. Recovery was uneventful, and the patient was given replacement therapy. On histologic examination,the cyst wall showed low pseudostratified cuboidal epithelium and occasional squamous metaplasia. Hemosiderin-filled phagocytes and acinar structures were also seen. The diagnosis was probable rupture of an intrasellar epithelial cyst, leading to empty sella syndrome.

Adolescent↗

Familial cerebral sarcomas.

Four cases of cerebral fibrosarcomas occurring in two families are reported. To our knowledge, no similar cases have been reported. Evidence that a heritable factor is involved in the genesis of some brain tumors is suggested by these cases.

Aged↗