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W M Knight

Publications and source records attributed to W M Knight.

9 recordsLinked to original sources
PubMed1987

Responsibilities of animal scientists and drug sponsors when conducting research with investigational new animal drugs.

The Center for Veterinary Medicine of the Food and Drug Administration (FDA) is charged with implementing the Federal Food, Drug and Cosmetic Act as it pertains to animal drugs and food additives. Title 21 of the Code of Federal Register Part 500 contains the regulations promogulated by the FDA as it implements this Act. Investigational New Animal Drug (INAD) applications provide for the shipment of experimental drugs and provide for the establishment of reconditioning procedures so edible products from research animals may be used for food. The record-keeping requirements for holders of INAD and for researchers are described. Protocol development and importation of investigational new animal drugs are discussed.

Animals↗
PubMed1979

Bioassay of vitamin A in liquid supplements.

Vitamin A bioassay techniques based on liver storage in the chick were adapted for the assay of vitamin A in molasses based liquid supplements for cattle. Methods of administering the assayed supplement to the chicks were: 1) direct dosing of the supplement via four crop infusions at hourly intervals and 2) ether extraction, suspension in cottonseed oil with solvent removal in vacuo followed by direct crop dosing. The last method allowed a larger dosage with fewer analytical problems. Five sequential extractions were required for 97% recovery of the vitamin A from the molasses supplement. With the higher dosage range, the variance of response was a function of dose level. Transformation to a log dose - log response curve allowed a linear plot with homogeneity of variance. Detection of a 10% loss of vitamin A potency (P less than .10) was estimated to require 27 chicks per treatment by the slope ratio bioassay procedure.

Animal Feed↗