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Biomedical subjects

W M Lester

Publications and source records attributed to W M Lester.

25 records · Page 2Linked to original sources
PubMed1986

Diabetes mellitus for 25 years or more. Analysis of cardiovascular findings in seven patients studied at necropsy.

Observations are described in seven patients (four women and three men) aged 38 to 76 years who had had diabetes mellitus for 25 years or more. Five had been treated with insulin, and two had been treated with diet and oral hypoglycemic agents only. Four patients had had bilateral leg amputations, one angina pectoris, and two left-sided congestive heart failure. Two died suddenly, two died of acute myocardial infarction, two died of infection, and one died from trauma. Transmural left ventricular scars were present in five patients and transmural necrosis in three patients. All seven patients had two or more major epicardial coronary arteries narrowed more than 75 percent in cross-sectional area by atherosclerotic plaque. Of 353 segments, each 5 mm, from the four major epicardial coronary arteries from the seven patients (mean 50 per patient), 53 (15 percent) were narrowed up to 25 percent in cross-sectional area, 116 (33 percent) were narrowed 26 to 50 percent, 110 (31 percent) were narrowed 51 to 75 percent, 66 (19 percent) were narrowed 76 to 95 percent, and eight (2 percent) were narrowed 96 to 100 percent. What allowed such long survival in these seven patients is unclear. It is clear that all had severe coronary arterial narrowing by atherosclerosis.

Adult↗
PubMed1984

Nodular pulmonary amyloidosis.

An elderly man had a 10-year history of multiple pulmonary nodules that he had refused to have investigated. He died of a ruptured abdominal aortic aneurysm. At autopsy the nodules were shown to consist of amyloid. There was no evidence of systemic amyloidosis.

Aged↗
PubMed1981

Hypertrophic osteoarthropathy complicating metastatic ovarian adenocarcinoma.

This report documents for the first time the association of hypertrophic osteoarthropathy with ovarian adenocarcinoma metastatic to the lung, in a 47-year-old woman who became totally incapacitated by her joint pain. Surgical removal of the lung metastases resulted in prompt relief of her pain. Theories of the pathogenesis of this clinical syndrome are reviewed. They include neurovascular, humoral and estrogenic mechanisms. Pulmonary arteriovenous shunting has also been considered in the pathogenesis. Operation should be considered in all patients who area incapacitated by joint pain associated with metastatic disease in the lungs.

Adenocarcinoma↗