White blood counts in radiation workers.
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Biomedical subjects
Publications and source records attributed to W M Politzer.
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Automated colorimetric and copper sulphate (4 solutions with different specific gravities) methods were used to examine 218 blood specimens. The correlation between the two was high (r = 0.82)--proving that the copper sulphate method is reliable for haemoglobin screening. Copper sulphate gives better results in the higher haemoglobin region, which includes the majority of healthy people. In the lower haemoglobin region this method generally gives lower results than the cyanmethaemoglobin method. Copper sulphate is also by far the cheapest means currently available for mass screening.
A patient with a fracture of the left femur was investigated for suspected multiple myeloma. Serum total proteins, protein electrophoresis, and immunoglobulin G, A and M levels were within normal limits. Bence Jones proteinuria of the lambda type was present. Subsequent investigations revealed the presence of IgD myeloma.
The diagnosis of multiple myeloma (overt plasma cell dyscrasia) is usually not considered in patients under 30 years of age. Furthermore, multiple myeloma with coexistent megaloblastic and iron deficiency anaemia is very uncommon. Within 6 months we encountered 2 patients under 30 years of age who had multiple myeloma, one with advanced secondary amyloidosis and the other with severe megaloblastic and iron deficiency anaemia.
The presence of two or more monoclonal proteins in serum due to the malignant proliferation of more than one clone of B lymphocytes is uncommon. A patient with raised levels of both immunoglobulin G and M is presented and some clinical and laboratory features are shown.
Hypovitaminosis A was found to be an important cause of menorrhagia, and a statistically significant difference between the fasting serum vitamin A values of healthy controls and patients with menorrhagia was noted. Vitamin A is a co-factor of 3 beta-dehydrogenase in steroidogenesis and deficiencies of this vitamin may result in impaired enzyme activity. The level of endogenous 17 beta-oestradiol appears to be elevated with vitamin A therapy, and menorrhagia was alleviated in more than 92% of patients.
An evaluation in terms of performance and cost was made of the Planotest, Pregnex, Gravindex, Prepurex, Planosec, Quick Test and Dap Test pregnancy test kits. It was found that Pregnex was the most accurate, but that it was expensive. Planotest, Gravindex and Prepurex were identical as far as results were concerned and they were comparable in price. In terms of readability, Gravindex, Pregnex and Prepurex were considered the easiest. Because many pregnancy test kits are available, we thought it desirable to compare these kits in terms of cost and performance.
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