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Biomedical subjects

W M Stewart

Publications and source records attributed to W M Stewart.

At least 19 recordsLinked to original sources

[Pemphigus and pemphigoid].

This comparison of the two diseases--pemphigus and pemphigoid--aimed particularly on points of actual interest. Are thus reviewed: (1) the research on the influence of racial or genetic factors in pemphigus vulgaris; (2) the striking differences between the immunological criteria of the two; (3) the clinical polymorphism of pemphigus: besides pemphigus superficialis, non-bullous forms, usually milder, of various types: herpetiformis, circinate ... are now being described; (4) the importance in all cases of eosinophilic spongiosis; (5) the clinical monomorphism of classical bullous pemphigus; on the contrary, the differences, both from clinical and prognostic points of view, in localized bullous pemphigoid (from the benign mucocutaneous form to the severe scarring disease) and in bullous pemphigoid of children; (3) the cases of genuine pemphigus induced by drugs (D-penicillamine, rifampicine) and the problem of the pemphigus-like antibodies; (7) bullous pemphigoid, UV light and practolol; (8) the outstanding association of two major immune diseases, pemphigus vulgaris, myasthenia and thymoma; (9) the mixed bullous dermatoses: pemphigus vulgaris and dermatosis herpetiformis (to separate from herpetiform pemphigus), bullous pemphigoid and dermatosis herpetiformis (bringing up the unsolved problem of mixed or intermediate forms of the two diseases), bullous pemphigoid and pemphigus vulgaris, exceptionally seen, and (10) some news on therapy.

Adult↗

[Pseudo-angiosarcomatosis (kaposi) and arterio-venous fistulae (author's transl)].

In a few cases, arterio-venous fistulae of the lower limbs lead to cutaneous symptoms of the toes, feet or legs exactly similar to Kaposi's disease; the fairly precocious occurrence, the unilateral localisation, the existence of clinical and radiological arterial symptoms and usually, but not always, particular histological features allow this discrimination. Seen in both sex, male prevailing, between 12 and 50, it can simulate Kaposi's disease even on histological grounds; the diagnosis may, then, be difficult inasmuch as vascular symptoms may clinically lack. The development may be very different from one case to another so that there is no standard treatment between "wait and see" and more or less extensive amputation.

Arteriovenous Fistula↗

[Multiple kerato-acanthomas and visceral carcinomas: Torre's syndrome].

Women 63-between 1949 and 1970 has shown 11 K. A., 1 Bowen's diseas of the vulva, a carcinoma of the rectum (together with a carcinoma of the anus). This last association allows to integrate this observation to Torre's syndrome. No return of the K. A. since the removal of the carcinomas (1970) which have not actually come out again.

Anus Neoplasms↗

[Strontium 90 in the treatment of pre-cancerous lesions and of some superficial skin cancers (author's transl)].

The use of strontium 90 has proved to be efficient and practical, because handy, and permitting short treatment, not only, to cure benign superficial tumors and, as reported in this study, of pre-cancerous lesions such as actinic keratosis, Bowen's disease of the skin but also some carefully chosen cases of superficial carcinomas. Hundred lesions have been so treated and followed for 3 years; two only have relapsed. The cosmetic result has been excellent in 80 p. 100.

Aged↗

[Cutaneous cholesterol emboli (author's transl)].

Fifty cases from the literature and one personal case of cutaneous cholesterol embioli are reviewed. These emboli come from abdominal atheromatous aotitis, sometimes complicated by aneurysm. The cholesterol micro-embolism is sometices induced by vascular surgery or arterial opacification. Male prevalence (47 cases) is evident. Alone or with visceral involvement, cutaneous lesions frequently simulate periarteritis nodosa: circumscribed to abdomen, thighs, legs, dorsum of the feet, the livedo reticularis is the most stricking feature associated or not with cutaneous nodes, purple toes, ulcers and gangrene. Histopathologic study is required for diagnosis: showing "negative" pictures of cholesterol cristals in an obliterating arteriolitis. Nevertheless special intetest is focused on a macrophagic granuloma centered in the vessel.

Aged↗

[Lichen striatus; histologic features (author's transl)].

The histologic picture of lichen striatus is not uniform and changes, as it seems, with the "oldness" of the lesion; showing: sometimes a dense lympho-histiocytic infiltrate of the papillary dermis and epidermis, sometimes features of atypical lichen planus. The existence of spongiotic vesicles in the low epidermis and in certain late forms, pictures of disruption of the basal layer with residual cavities compose particular data of the disease.

Diagnosis, Differential↗

[Diffuse skin mastocytosis of nurslings. 3 clinical cases with bullous manifestations].

Three nurslings are described with diffuse mast cell disease characterized by blisters on widespread skin involvement. The skin changes may be associated with important generalized flares in relation with degranulating mast cell. The mastocytosis infiltrats seems localized to the skin. The skin lesions heal or regress slowly as in other mast cell disorders but long-term evolution remains very impredictable.

Blister↗