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Biomedical subjects

W M Stone

Publications and source records attributed to W M Stone.

25 records · Page 2Linked to original sources
PubMed1967

Larval distribution and histopathology of experimental Strongyloides ransomi infection in young swine.

Necropsy at various intervals of three week old pigs following experimental infection with larvae of Strongyloides ransomi showed distribution of the larvae through the body during the first 24 hours. Quiescent larvae at the 24 hour necropsy, as indicated by higher recovery before and after this period may be an indication of physiological changes preceding a moult. Whether or not a moult occurs in the lung prior to migration of the larvae to the intestine has not been determined. At the 72 hour necropsy, larvae were largely confined to the lung and juvenile worms were beginning to appear in the small intestine. Migration to the small intestine was completed by the 96 hour necropsy. Lesions were observed in the skin and lungs up to the 96 hour necropsy, and lymphocytic accumulations were observed in the skin and lungs to this point and lymphocytic accumulations were observed in the liver to the 72 hour necropsy. At 28 days post-application lung lesions were still evident and the duodenum and jejunum were heavily parasitized. Egg passage began on the sixth day post-application and peaked on the 12th day.

Animals↗
PubMedDate not supplied

Catastrophic weight loss after vertical banded gastroplasty: malnutrition and neurologic alterations.

The case of a patient with severe vomiting and very rapid weight loss following vertical banded gastroplasty (VBG) (almost 50% of original weight in 11 months) and who suffered severe neurological and nutritional disorders is reported. All abnormal findings with the exception of nystagmus, disappeared during enteral nutritional support with a complete diet and vitamin supplementation. The alterations found in this case may have been related to the very rapid weight loss, which resulted in protein calorie malnutrition and, probably, in one or more vitamin deficiencies. This complication may be preventable by early nutritional intervention in subjects undergoing gastric reduction surgery and who exhibit very rapid weight loss and intractable vomiting.

Adult↗
PubMedDate not supplied

Executive function and magnetic resonance imaging subcortical hyperintensities in vascular dementia.

OBJECTIVE: To determine the relation between subcortical hyperintensities (SHs) visible on magnetic resonance imaging and executive function among patients with vascular dementia. BACKGROUND: The relation between SHs and executive dysfunction is not well understood, because studies have varied widely in methodology and have produced conflicting results. METHOD: We examined the relation between SHs (expressed as a percentage of total brain volume, not including ventricular volume) and six tests of executive function in a well-defined group of 24 individuals with vascular dementia. Executive tests were divided in two groups: Attention/Speed and Abstraction/Problem Solving. Bivariate correlations were computed between individual neuropsychological variables and SHs. RESULTS: Results showed significant bivariate correlations between SHs and three of the four tests in the Attention/Speed domain. Subcortical hyperintensities shared virtually no association with performance on tests in the Abstraction/Problem-Solving domain. CONCLUSIONS: The finding that SHs are significantly associated with psychomotor slowing and attentional dysfunction is consistent with what is known about the behavioral manifestations of subcortical disease. More detailed investigations of the regional distribution of SHs as well as measures of atrophy, hypoperfusion, and hypometabolism may be necessary to accurately characterize the complex relation between vascular disease and different aspects of executive dysfunction.

Aged↗