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Biomedical subjects

W M Zhang

Publications and source records attributed to W M Zhang.

At least 73 records · Page 4Linked to original sources
PubMed1988

Treatment of longitudinal injuries in avascular area of meniscus in dogs by trephination.

A study promoting the healing of longitudinal injuries in an avascular area of the meniscus in 21 male dogs is reported. One horizontal hole from the peripheral vasculature to one of the artificial longitudinal injuries to both medial menisci of the knee in each dog was made with a needlelike trephine. The knee joints were not immobilized and the samples were taken 2, 4, 8, 12, and 24 weeks, respectively, after the operation. [3H]Thymidine was injected into the joint cavity 72 h before the sample was taken. Healed lengths were measured, and pathologic examinations and autoradiography were performed. The results showed that all of the injuries treated with trephination were partly or totally healed whereas those in controls were not healed at all, suggesting that trephination may be the procedure of choice for clinic orthopedists dealing with such injuries. By the 8th week, the healed length stopped increasing, the scar tissue began to mature, and the DNA synthesis of the fibroblasts in the granulation tissue and the fibrochondrocytes in the trephined meniscus reduced. It is thought that the fibrochondrocyte of the meniscus and the fibroblast in the granulation might be capable of obtaining the thymidine directly from the synovia of knee joint for their DNA metabolism. Multiplication of the fibrochondrocyte in the injured meniscus was also found.

Animals↗
PubMed1986

Suture and immobilization of acute peripheral injuries of the meniscus in rabbits.

A comparative study of suturing or nonsuturing with or without immobilization of acute peripheral injuries to the medial meniscus of rabbits is reported. Artificial injuries to both knees of 44 male China Blue-Violet rabbits were sutured or left unsutured. One knee joint of each rabbit was immobilized postoperatively for 6 weeks. The maximum breaking strength was measured, pathologic examinations were performed, and healed areas were measured. The results showed that there was greater healed area, higher maximum breaking strength, earlier matured scar tissue formation, and more regular fiber alignment in the treatment groups with simple immobilization of the knee joint. These results were superior to suturing plus immobilization, suggesting that external immobilization of the knee joint is the key to the treatment of acute peripheral injuries of the meniscus. It may be the procedure of choice for clinical orthopedists dealing with such injuries. The measurement of the meniscus healed area and maximum breaking strength and the use of new material with this method of immobilization were introduced by the authors.

Acute Disease↗
PubMed1986

A quantitative and histological study on pulmonary effects of asbestos exposure in general autopsied lungs.

We demonstrated the distribution of asbestos bodies (ABs) in the lungs of 656 consecutive autopsy cases by KOH digestion method. Nine patients including one case with asbestosis had more than a thousand ABs. These patients were all blue-collar workers except the two cases without occupational history. The tissue sections for these patients revealed the constant presence of more than one or two ABs. In addition, five of these subjects had parenchymal and/or peribronchiolar fibrosis. On the basis of the result of AB counts, we selected 17 subjects for enumeration and typing of asbestos fibers (AFs). The number of AFs roughly correlated with that of ABs. However, the ratio of AFs to ABs ranged from 13 to 3,700. The fiber types in our selected subjects were almost always amphibole (crocidolite, amosite). These findings indicate that modest or secondary exposure to asbestos causes virtual asbestosis to several subjects among the general population.

Adult↗