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Biomedical subjects

W Mönninghoff

Publications and source records attributed to W Mönninghoff.

At least 19 recordsLinked to original sources
PubMed1987

[Fine structure of surviving heart muscle cells in ventricular aneurysms].

Surgically-obtained tissue specimens from 41 patients with ventricular aneurysm were studied electron microscopically. The tissue from the resected aneurysms showed substantially varied morphological differences. In some, there were extensive regions of scar containing increased fibrotic material and few cells, in others there were also larger contiguous regions of myocardium with an essentially normal appearance. In the preserved myocardial regions, the cardiac cells showed moderate hypertrophy. There was an increase in contractile substance in parallel with an increase in mitochondria and enlargement of the nucleus with frequent waves and invaginations in the cell membrane. The cells at the marginal regions between fibrous tissue and preserved myocardium were frequently isolated from adjacent cells. In particular, when the isolated cells were completely surrounded by fibrous tissue, clear degeneration was apparent. These cells showed mainly a fibrillolysis with dissolution of the cross-bands and loss of the entire contractile apparatus. In compensation, occasionally there was proliferation of other cell structures, especially the free sarcoplasmatic reticulum. The hypertrophy of the still intact myocardial cells is considered compensatory for the infarct-incurred loss of tissue. The degenerative appearance is mainly attributable to fibrous tissue invasion. The diminished oxygen supply, compromised or abolished impulse conduction, loss of function and passive stretch during systole may be regarded as causes of the degeneration.

Actin Cytoskeleton↗
PubMed1983

[How dangerous is the dipyridamole test?].

In 203 patients with clinical symptoms of coronary artery disease, cardiac and extracardiac side effects of the dipyridamole test were investigated. Following dipyridamole (0.75 mg/kg body wt. i.v.), heart rate increased significantly, whereas arterial blood pressure remained almost constant. Dyspnea was noted in 80 cases (40.5%). In 48 patients (23.6%) rhythm disturbances were recorded; 58.1% suffered from extracardiac side effects such as congestion in the head, vertigo, heaviness of arms and legs, sensations of heat, upper abdominal pain, and nausea. A detailed report is given of 4 cases with extraordinary symptoms during or after the injection of dipyridamole. A life-threatening status anginosus with dyspnea, ST-segment elevation, and cardiac arrhythmia was observed in one of these cases. High-dose dipyridamole cannot be considered to be harmless. The test should not be performed without continuous ECG monitoring and other safety measures.

Adult↗
PubMed1981

[Roentgenologic diagnosis of coronary vessel calcinosis in patients over 65 years of age].

215 out-patients aged between 65 and 88 years (average age 70.3 years) were examined radiologically for coronary calcification. In 62.5% of the cases positive results were obtained with a prevalence of men over women. From the 134 patients with coronary calcification 81.5% had a pathological ECG and 32% of these showed evidence of transmural infarction. The combination of coronary calcification and chronic arterial hypertension was found in 68.5% of the patients. In our opinion radioscopy of the heart for the detection of coronary calcification is of particular diagnostic value, on account of its safety and simplicity, especially with elderly patients; all the more so since the otherwise usual diagnostic techniques such as ergometry and selective coronary angiography can, for reasons of age, only be performed in certain cases.

Aged↗
PubMed1977

[The significance of coronary artery calcification seen by roentgenoscopy (author's transl)].

The detection of coronary artery calcification by roentgenoscopy is an important hint at possible ischemic heart disease. By the advent of image intensification and magnification, this examination can easily be performed. If no calcifications are visible, an ischemic heart disease must not be excluded. The presence of calcification in the coronary arteries however strongly favours the diagnosis of arteriosclerotic heart disease. The roentgenoscopical search of coronary calcification is considered to be a valuable procedure since it is inexpensive, noninvasive and widely applicable.

Adult↗