[The effect of coffee on the functions of the sense organs and on the central nervous regulatory mechanisms].
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Biomedical subjects
Publications and source records attributed to W Müller-Limmroth.
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In a double-blind cross-over study 15 highly motivated, healthy male subjects (Ss), aged from 23 to 29 years, were given 200 mg and 400 mg p-methoxy-phenoxyaceticacid-diethylaminoethylamide-hydrochloride (mefexamide) and a placebo. On each of the three days the Ss were tested in different tracking devices and the integrated absolute error was measured in the tests of a duration of three hours each. Influences of practice, leading to unwanted and disturbing effects were excluded by a preceding period of four training sessions on different days. The main result of the investigation was that performance in tracking was ambivalent. The single dosage (200 mg mefexamide) caused small improvements in tracking in the range of about 5%. These differences from placebo partly could be determined to be significant at the level of 5% compared to placebo. The double dosage (400 mg mefexamide) deteriorated tracking performance significantly (5%-and partly 1%-level, two-tailed test) in the range of about 10% on the average. Differences in performance between the two dosages were correspondingly larger and could be determined at a higher level of significance, too.
The influence of orally administered carbohydrates and bicycle work on muscle hexokinase activity, blood glucose, and serum insulin levels were studied in 6 young men. Continuously administered glucose of a total amount of 150 g caused a significant increase in hexokinase activity within 3 hrs. Working at a load of 155 to 195 Watt led to an initial increase of hexokinase activity. At the end of the working period hexokinase activity had fallen to resting values. The possible mechanisms of action are discussed.
By measuring the capacity for absorption of water and heat output of the hay flower sack (pack) used in Kneipp therapy, it was established that finely chopped hay absorbed less water with less statistical scatter than the flowers and fruit (Flores graminis), but more than cellulose, bandaging materials and Styropor. The hay particles should have a surface of not less than 4mm. According to the behavior of the water absorption, a hay flower sack connot be used more than twice. From the behavior of the heat output, the hay flower sack should be applied directly to the body and covered. In this way the storage period can be extended significantly by 10 minutes to a maximum of 50 minutes. Compared with the hot water bottle, kaolin poultice and mud pack, the hay flower sack emits an intensely moist heat better and for a longer time.
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