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Biomedical subjects

W Maguire

Publications and source records attributed to W Maguire.

6 recordsLinked to original sources
PubMed1992

Hyperventilation syndrome and the assessment of treatment for functional cardiac symptoms.

Three methods of breathing retraining (guided breathing retraining, guided breathing retraining with physiologic monitoring of thoracic and abdominal movement plus peripheral temperature, and guided breathing retraining with physiologic monitoring of thoracic and abdominal movement, peripheral temperature and end-tidal carbon dioxide) were compared with a no-treatment control group to determine the effectiveness of breathing retraining on modifying respiratory physiology and reducing functional cardiac symptoms in subjects with signs associated with hyperventilation syndrome. Of 41 subjects studied, 16 were diagnosed with mitral valve prolapse. Results demonstrated that all 3 methods of breathing retraining were equally effective in modifying respiratory physiology and reducing the frequency of functional cardiac symptoms. Results determined that respiratory rate and subject's perception that training had generalized were the best predictors of treatment success. Furthermore, it was found that subjects with mitral valve prolapse responded as well to treatment as did those without prolapse.

Adult↗
PubMed1979

Cutaneous myiasis in visitors to Central America.

Six cases of cutaneous myiasis occurred in three groups of visitors to Guatemala between February and May 1978. Attack rates ranged from 12% to 50%. Furuncular lesions were generally multiple and involved both exposed and usually unexposed areas of the body. Parasitic fly larvae recovered from two patients were identified as the botfly, Dermatobia hominis. Botfly infestation is endemic in areas of Central and South America and is acquired indirectly through the bite of carrier arthropods, including mosquitoes. Although reports of cases in North Americans visting endemic areas are rare, the condition is probably much more common in such persons than it is currently believed to be. A history of travel to Central or South America should suggest the diagnosis.

Adult↗
PubMed1977

A phantom-motion aftereffect.

Motion aftereffects, typically found to result only from localized retinal stimulation, were obtained within regions of the visual field that had not been stimulated by moving contours. "Phantom" stripes are seen moving through a physically homogeneous (empty) region of the visual field when vertical stripes move above and below that region. Immediately afterward, stationary stripes in the previously empty region appear to move in the opposite direction. This phantom-motion aftereffect provides a novel instance of the way global structure affects processes that have been assumed to be influenced only by simpler local spatial and temporal variables.

Afterimage↗
PubMed1975

The effect of glucagon on airway resistance.

Nine subjects with obstructive airway disease took part in this double-blind study of the effect of glucagon in relieving bronchoconstriction compared with isoproterenol or isotonic saline. Drugs were administered via an in-line intermittent positive-pressure breathing unit. FEV1, MEF, PEF, and nitrogen washout data were evaluated. Ten minutes after administration of saline, mean FEV1 and MEF values were significantly reduced from baseline levels (P less than 0.05). Compared to saline, isoproterenol was followed by significantly increased FEV1 and MEF values (P less than 0.05) at both 10 and 30 minutes after medication, indicating reduction in bronchoconstriction. Although the 1-mg dose of glucagon was followed by a mean decrease in these parameters, this decrease was less than that seen after saline alone.

Adolescent↗
PubMedDate not supplied

The effect of cycloserine on pyridoxine-dependent metabolism in tuberculosis.

Measurements were made of urinary tryptophan metabolites of 13 tuberculosis patients in order to reveal characteristics of pyridoxine-dependent metabolism before and during cycloserine treatment. The abnormally high level of xanthurenic acid excretion in untreated patients suggests a decreased availability of pyridoxal phosphate related to the disease process. Although plasma cycloserine levels were kept high once therapy began, xanthurenic acid excretion before and after tryptophan load became progressively more normal as symptoms diminished. This observation suggests that the convulsions which may sometimes accompany cycloserine administration are not due to a direct pyridoxine antagonism by the drug. Throughout the study, no significant changes in 5-hydroxyindoleacetic acid excretion were observed. Presumably, the metabolic pathway of serotonin is unaffected by tryptophan loading, cycloserine administration, or the apparent pyridoxine depletion associated with tuberculosis.

Cycloserine↗