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Biomedical subjects

W Markiewicz

Publications and source records attributed to W Markiewicz.

At least 55 records · Page 3Linked to original sources
PubMed1980

The heart in acromegaly: correlation of echocardiographic and clinical findings.

Echocardiography was performed in 14 patients with acromegaly in order to characterize cardiac involvement in this disease. The left ventricle was enlarged or hypertrophic in 10 patients (71%): the fraction of myocardial shortening, an index of left ventricular contractility, was normal in all but one; and 10 patients had a reduced mitral EF slope, suggesting that their left ventricular compliance was reduced. Cardiac disease was not suspected clinically as most patients had normal clinical, ECG and X-ray examinations of the heart. Left ventricular hypertrophy occurred in the absence of hypertension, diabetes or evidence of coronary artery disease. There was a positive correlation between left ventricular wall thickness and duration of acromegaly but not between the former and growth hormone levels after fasting, suggesting that ther must be prolonged hypersecretion of growth hormone, and not simply high levels, before cardiac hypertrophy develops.

Acromegaly↗
PubMed1979

The heart in acute glomerulonephritis: an echocardiographic study.

Patients with acute glomerulonephritis often are seen with signs suggesting heart failure. Whether these signs are due to fluid overload secondary to kidney damage only, or whether there is associated myocardial damage has not been elucidated. Fourteen children with acute glomerulonephritis were studied by echocardiography during the edematous phase of the disease and five months later to evaluate cardiac function in this disease. Left ventricular size and function remained normal in all children throughout the study. The most consistent finding was enlargement of the left atrium during the edematous phase with a return toward normal values five months later. There was no correlation between blood pressure and the echocardiographic findings. This study suggests that signs of heart failure in acute glomerulonephritis are not due to myocardial damage but probably reflect fluid overload.

Cardiomegaly↗
PubMed1979

Effect of large doses of morphine on experimental myocardial ischemia in cats.

The effect of large doses of morphine (1 mg/kg, i.v.) on experimental myocardial ischemia was evaluated in anesthetized open-chest cats. Myocardial ischemia was produced by intermittent coronary artery occlusion and assessed by measuring ST-segment elevation in multiple epicardial leads. The results obtained in the group of animals given morphine were compared with values obtained in animals given saline (control group), propranolol or nitrous oxide (reference groups). Morphine injected before coronary occlusion produced a significant increase in ST-segment elevation after left anterior descending coronary artery occlusion, whereas no significant change was noted in animals receiving normal saline or nitrous oxide. As expected, in the animals that received propranolol there was a pronounced decrease in ST-segment elevation. Our data suggest that large doses of morphine may increase myocardial ischemia when administered before coronary occlusion in the anesthetized open-chest cat.

Animals↗
PubMed1979

Echocardiography in infective endocarditis. Lack of specificity in patients with valvular pathology.

59 patients with suspected infective endocarditis on a natural valve were studied by M-Mode echocardiography to determine the specificity of the ultrasonic technique in detecting valvular vegetations. All echocardiograms were read independently by two observers who were unaware of the final diagnosis. Among 40 patients who later proved not to have infective endocarditis, two (5%) were diagnosed by echocardiography as having either possible or probably vegetation by at least one observer. Both patients with a false positive diagnosis of vegetation had pre-existing valvular pathology, the presence of which greatly complicated the interpretation of the echocardiogram. Inter-observer disagreement occurred in 5 of the 59 studies (8.5%). The results of this study suggest that caution should be exerted in the echocardiographic diagnosis of vegetation in patients with pre-existing valvular pathology.

Adolescent↗
PubMed1979

A comparison of static and dynamic exercise soon after myocardial infarction.

The cardiovascular response to treadmill exercise testing and to isometric handgrip was compared in 20 selected patients three to five weeks after acute myocardial infarction. The heart rate and the heart rate-systolic blood pressure product were significantly higher during treadmill exercise than during two minutes of isometric handgrip sustained at 25% of maximum voluntary contraction. No significant difference in systolic blood pressure was noted between the two types of exercise while diastolic blood pressure was higher during isometric exercise. Asymptomatic ST-segment depression was noted in two patients during the the treadmill test and was absent during handgrip. Angina pectoris was not noted during either type of exercise. Ventricular ectopic activity was slightly more frequent during treadmill exercise. Isometric handgrip at 25% of maximum voluntary contraction may be performed safely soon after myocardial infarction and provides useful guidelines for performing many customary physical activities requiring upper extremity isometric exertion during early convalescence.

Blood Pressure↗
PubMed1978

Contribuiton of M-mode echocardiography to cardiac diagnosis. An assessment in 1,000 successive patients.

The contribution of M-mode echocardiography to cardiac diagnosis was evaluated in a series of 1,000 successive patients. Among subjects in whom a presumptive clinical diagnosis had been made, echocardiography demonstrated totally unexpected findings in 10 per cent, supported the clinical diagnosis in 50 per cent and was entirely within normal limits in 19 per cent. Among patients with evidence of heart disease but no firm clinical diagnosis, echocardiography established the diagnosis in 23 per cent, including 20 per cent of all patients referred for evaluation of chest pain or arrhythmia of unclear etiology. "Missed" clinical diagnosis frequently involved patients with mitral valve prolapse, congestive cardiomyopathy, pericardial disease or asymmetrical septal hypertrophy of the heart. This study quantifies the amount of independent information contributed by echocardiography to cardiac diagnosis and demonstrates that this technic provides data of important clinical relevance in a surprisingly large number of cardiac patients.

Adult↗
PubMed1977

Echocardiographic detection of pericardial effusion and pericardial thickening in malignant lymphoma.

Serial echocardiographic examinations of the heart were obtained for 13 patients undergoing irradiation for malignant lymphoma. Eleven of these had been shown to have mediastinal adenopathy; none had clinically detectable pericardial disease. The pericardial effusion which had been echocardiographically evident in 6 patients prior to treatment disappeared during or subsequent to the course of radiotherapy. Small asymptomatic effusions appeared in 5 patients during the follow-up period. Pericardial effusions, detected easily by echocardiography, occur more commonly than hed been previously thought in patients with malignant lymphoma.

Adolescent↗