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Biomedical subjects

W Matek

Publications and source records attributed to W Matek.

At least 19 recordsLinked to original sources
PubMed1990

[The retrograde endoscopically implantable, self-expanding endoprosthesis (stent) in malignant choledochal stenoses].

Self-expanding, wire-mesh stents, 10 mm in diameter, were implanted retrogradely through the papilla of Vater via an endoscopically introduced catheter system in 14 patients (9 females, 5 males, mean age 70.2 [44-85] years) with stenosis of the common bile duct by malignant tumour. Postimplantation examinations revealed no complications caused by the stent. Two of the patients have since died from their underlying disease, the others have survived an average of 10.8 weeks with markedly reduced clinical symptoms, neither jaundice nor signs of cholestasis having recurred. Serum bilirubin concentration had fallen from a mean of 8.2 mg/dl to 1.7 mg/dl 12 weeks after the procedure. Serum alkaline phosphatase activity had similarly fallen, from 515 to 330 U/l. No increase in serum amylase activity was recorded, either initially or in the course of follow-up.

Aged↗
PubMed1990

Transpapillary miniscopy and mini-biopsy of the pancreatic duct.

This paper reports on the new combined examination of peroral transpapillary fine-caliber endoscopy (miniscope 0.5 mm in diameter) with mini-biopsy of the pancreatic duct in 10 patients and 19 surgical pancreas resection preparations. With this technique, endoscopic-retrograde inspection of the whole length of the pancreatic duct is possible without the need for papillotomy. In the case of pancreatic duct changes due to carcinoma of the pancreas, and chronic pancreatitis, the ductal lesions can be inspected. Furthermore, with the aid of a new mini-biopsy forceps (1.5 mm in diameter), material for histological evaluation can be much more efficiently obtained than was normally possible with conventional biopsy forceps (2.2 mm). This new endoscopic-bioptic technique promises to improve the diagnostic reliability in pancreatic duct lesions requiring clarification.

Biopsy↗
PubMed1990

Self-expanding mesh stent for esophageal cancer stenosis.

The implantation of new self-expanding mesh stents (20 mm in diameter, when fully expanded) in a 67-year-old woman with extensive esophageal cancer stenosis is reported. Prosthesis insertion was easily accomplished without the need for general anesthesia. The patient has been doing well since. The potential advantages of the new stenting procedure suggest further investigation.

Aged↗
PubMed1989

A comparative study of the tissue-destroying effect of the laser and electrocoagulation.

The effect of the laser on compact, glandular tissue at the dosage employed for the local palliative treatment of tumors, can largely be mimicked with the aid of high-frequency current (HF-current), applied with the aid of an electro-hydro-thermo-probe: The experiments described in the present study were performed on the livers of 70 male Wistar rats. The laser was applied for 2 seconds at an output of 80 J at a distance to the tissue of 0.5 cm. In the first stage, in the acute experiment, the effect of the HF-current was matched to that of the laser by varying the modulated and unmodulated current components. It was found that the depths of penetration into the tissue at the given laser settings could be achieved with modulated HF-current (so-called coagulation current) at an output of more than 72 watts (equipment setting K 10) coagulation being performed for 10 seconds. The admixture of modulated HF-current (so-called cutting current) reduces the depth of penetration into the tissue. In the first 5 days, the depth of penetration increases after both laser irradiation and HF-coagulation, by a factor of 2 to 3. With respect to the depths of penetration (DP), the scatter ranges, and the histological changes, no difference is to be seen between laser and HF lesions: Laser DP = 5.7 mm (confidence range: 4.4-7.0 mm); HF DP (equipment setting K 10) = 4.8 mm (confidence range: 3.6-5.4 mm).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1989

Extracorporeal piezoelectric shockwave lithotripsy of multiple pancreatic duct stones under ultrasonographic control.

The first ultrasonographically controlled fragmentation of multiple pancreatic duct stones of up to 14 mm size by means of extracorporeal, piezoelectric shockwave lithotripsy is reported. On account of the ultrasound localization and continuous control during therapy a nasopancreatic tube for instillation of contrast medium and frequent x-ray checks were not necessary. The 48-year-old patient did not experience any pain during the four treatment sessions and during the follow-up period. No complications were noted.

Calculi↗
PubMed1989

Transpapillary cholecystoscopy.

This report describes the inspection of the inside surface of the gallbladder and the cystic duct by a newly available catheter and endoscopic system, with the aid of retrograde endoscopy. Using our newly developed endoscopic retrograde catheter system, we were able to cannulate the gallbladder in nearly 80% of all cases. No papillotomy is needed. Owing to its high degree of flexibility and relative robustness, coupled with brilliant optical quality, the new 0.5 mm miniscope permits careful and virtually complete inspection of even such small structures as the tortuous cystic duct.

Catheterization↗
PubMed1988

Mechanical lithotripsy of bile duct stones in 209 patients--effect of technical advances.

Between 1982 and 1987, mechanical lithotripsy of common bile duct (CBD) stones was performed in 209 patients (mean age +/- SD: 72 +/- 10 years), using self-constructed lithotripters and baskets with breaking strengths of approximately 50 and 100 kg between 1982 and 1986, and stronger and bigger baskets with breaking strengths of approximately 125 kg since 1987. Patients with single (49.3%) and multiple stones (50.7%) were distributed about equally. Stone size ranged between 4 and 80 mm (mean longitudinal diameter 18 +/- 9 mm, mean transversal diameter 13 +/- 3 mm), with a majority of the patients (61.2%) having stones of between 10 and 19 mm, and about one-third (32.1%) of the patients with stones greater than or equal to 20 (20-80) mm. The overall success rate of mechanical lithotripsy in all 209 patients treated between 1982 and 1987 was 87.6% including 79.1% for CBD stones greater than or equal to 20 mm and 67.6% for stones greater than or equal to 25 mm. The introduction of baskets with breaking strengths of approximately 125 kg in 1987 considerably increased the success rate of mechanical lithotripsy, especially for "large and giant" CBD stones, to 92.3% (greater than or equal to 20 mm) and 85.7% (greater than or equal to 25 mm), respectively.

Aged↗
PubMed1987

Biopsy histamine in ulcerative colitis and Crohn's disease.

The histamine content of biopsy specimens obtained from patients with ulcerative colitis (UC), Crohn's disease (CD), or polyps was measured in vitro. This was done using colonic and rectal mucosa taken from affected and healthy tissue. In general, the results demonstrate a significantly higher histamine content in patients with UC. This was true with respect to colonic as well as rectal mucosa. Moreover, affected mucosa contained significantly more histamine than normal in UC and in CD. The histamine content of colonic and rectal mucosa was similar within each patient group. However, specimens from patients with UC again contained significantly more histamine than did those of patients with CD. The data underscore a distinct pathomechanism in UC and in CD. Therefore, determination of the histamine content of biopsy specimens may be an adjuvant criterion for the discrimination of different inflammatory bowel diseases.

Adult↗
PubMed1986

Is the adenoma-carcinoma sequence contradicted by the differing location of colorectal adenomas and carcinomas?

This article takes a look at the different localisation of colorectal adenomas and carcinomas. The risk of malignancy of 4,257 adenomas found in 1742 patients was determined, and the lesions grouped in accordance with various criteria and risk classes. It was found that the distribution of adenoma locations approximated all the more closely to the distribution pattern of carcinoma sites, the higher the malignancy risk of an adenoma group was. The statistical approximation of adenoma and carcinoma localisations as a function of increasing risk of malignancy must be considered an argument in support of the adenoma--carcinoma sequence.

Adenoma↗
PubMed1986

Hemostasis--therapeutic alternatives to the laser.

In clinical practice, there are a number of other endoscopic procedures for attaining hemostasis available as alternatives to laser hemostasis. Of these the following may be emphasized: Modified electrocoagulation procedures such as EHT coagulation, bipolar or multipolar coagulation, and sclerotherapy. The efficacy of these "laser-alternative" methods of hemostasis has already been demonstrated in clinical studies, and is unquestioned. Large comparative investigations that would provide definitive information on the relative effectiveness of the various techniques, have yet to be carried out. If, however, we consider such aspects as practicability and economy, the laser would appear to be a "dinosaur" among the endoscopic procedures presently available for hemostasis. The oldest recognized fiber-endoscopic instrument for hemostasis, it is anything but highly mobile, and is bound to a fixed location. In addition, it is as expensive as a museum exhibit. If the only indication for its use were hemostasis, it would probably have vanished from the scene.

Electrocoagulation↗
PubMed1985

Follow-up of patients with colorectal adenomas.

With the aim of establishing suitable follow-up intervals, we examined the probability for the recurrence of relevant adenomas in the colorectum. A total of 592 adenoma patients in whom colonoscopy up to the caecum had reliably excluded relevant findings, were admitted to the study. Relevant findings were considered to be 1) colorectal carcinoma, 2) an adenoma with severe cellular atypia, 3) an adenoma of at least 5 mm in diameter, 4) a histologically unclassified polyp of at least 5 mm in diameter. We were able to show that the use of a dose-effect relationship is statistically justified for the follow-up results of the 592 patients. Thus, the probability for renewed relevant findings at any given time can be computed on the basis of the follow-up results. Renewed relevant findings were presented by 6.0% of patients with single adenomas after 4 years (confidence level 4.8-7.3%), while 5.7% of patients with multiple adenomas had relevant findings after 2 years (confidence level 4.5-7.0%). These follow-up intervals are, thanks to the adequate detection rate, economical and, at the same time, safeguard adenoma patients with a high level of reliability, against cancer of the colorectum.

Adenoma↗
PubMed1984

[Gold colitis].

Explore the source record for details and available documents.

Arthritis, Rheumatoid↗