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Biomedical subjects

W Mathisen

Publications and source records attributed to W Mathisen.

At least 37 records · Page 2Linked to original sources
PubMed1977

Metabolism of testosterone in the human prostate and seminal vesicles.

Tissue from the normal, hyperplastic and the cancerous human prostate as well as tissue from the human seminal vesicles are capable of metabolizing testosterone in vitro. By incubating minced tissue with 3H-testosterone for 2 hours at 37 degrees C the following radioactive metabolites were identified: testosterone (17 beta-hydroxyl-4-androsten-3-one), androstenedione (4-androstene-3,17-dione), androstanedione (5alpha-androstane-3,17-dione), 5alpha-dihydrostestosterone (17 beta-hydroxy-5alpha-androstane-3-one, DHT), 3alpha-androstanediol (5alpha-androstane-3alpha,17beta-diol), 3beta-androstanediol (5alpha-androstane-3beta-17beta-diol) and androsterone (3alpha-hydroxy-5alpha-androstane-17-one). When normal human prostatic tissue was incubated with 3H-testosterone approximately 40% of the hormone was metabolized and 30-35% of the metabolites were identified as DHT. There were apparently no differences in testosterone metabolism between the dorsal and lateral prostatic lobes. A much lower conversion of 3H-testosterone was observed in the seminal vesicles (24%). The same metabolites were formed by prostatic carcinoma tissue, although distinctive quantitative differences from the normal prostate were observed. Thus, only 23% of the testosterone was metabolized by cancerous tissue of which 15% was present as DHT. The formation of 17-keto metabolites and androstanediols in the prostatic carcinoma tissue was approximately the same as in the normal prostatic tissue. The most extensive metabolism of testosterone was found by incubation of tissue from benign nodular prostatic hyperplasia. About 65% of the testosterone was metabolized, and 40% of the metabolites were identified as DHT. Hyperplastic prostatic tissue also showed a significantly higher formation of 5alpha-androstanedoils and the other tissues examined. The high formation of DHT and 5alpha-androstanediols in benign nodular prostatic hyperplasia in comparison with normal and cancerous prostatic tissue and seminal vesicle tissue might indicate that these metabolites should be studied more closely as possible aetiological factors for prostatic hyperplasia. The very low metabolism of testosterone in prostatic carcinoma tissue should be examined further in relation to tumour differentiation and clinical effect of endocrine therapy.

Adenocarcinoma↗
PubMed1977

Total replacement of ureter with a segment of ileum.

Replacement of ureter with a segment of ileum was successfully performed in two patients. One had ureteral cancer and the other recurrent calculi due to cystinuria. The first patient had only one kidney. In the second both ureters were replaced with ileum. Formation of a papilla at the distal end of the ileal segment in the bladder may reduce the risk of vesico-ileal reflux.

Adult↗
PubMed1976

Duplication of the male urethra treated by septotomy. A case report.

In a case of incomplete duplication of the male urethra the interurethral septum was divided by scissors. After this simple operative procedure, the patient was relieved of his obstructive symptoms. Postoperative urethrography revealed considerable improvement of the calibre of the urethral lumen, and uroflowmetry showed almost normalized flow values. This technique is recommended as treatment in similar cases.

Humans↗
PubMed1976

Uretero-vaginal fistula.

Six cases of uretero-vaginal fistula are presented. Five patients developed this complication after gynaecological surgery and one after Caesarian section. Constant urinary incontinence combined with normal voiding is typical of this lesion. Excretory urography revealed a stricture in the distal part of the ureter in 5 cases, while in one patient the urographic findings were normal. Accumulation of contrast medium in the vagina was seen on urography in 2 patients. Surgical correction is the treatment of choice, and all patients were successfully treated by resection of the distal part of the ureter with reimplantation of the ureter into the bladder.

Adult↗
PubMed1975

Traumatic renal arteriovenous fistula treated by ligation and preservation of the kidney.

A case with traumatic renal arteriovenous fistula is presented. The diagnosis was established by selective renal angiography. The fistula was treated by ligation and division of the feeding artery. Postoperative angiography revealed complete closure of the fistula. The aetiology, clinical manifestations, diagnosis and treatment of renal arteriovenous fistula are discussed.

Adult↗
PubMed1975

A comparison between urography and radioisotope renography in the follow-up of surgery for hydronephrosis.

The result of surgical correction of hydronephrosis caused by chronic obstruction at the pyeloureteral junction has been evaluated clinically as well as by urography and body background substracted renography performed preoperatively and up to 65 months postoperatively. The average follow-up period was 24 months. Twenty-eight patients (29 kidneys) were operated. Clinically 24 patients were improved. Urography showed regress of hydronephrosis and/or improved urinary pelvic drainage in 22 patients, whereas kidney function is judged from renography was improved in only 8 patients. Improvement in all parameters was generally most marked during the first postoperative months. Renographic improvement was seen much more often when the contralateral (non-operated) kidney was abnormal. Thus, kidney function in terms of effective renal plasma flow is rather uninfluenced by hydronephrosis surgery if the contralateral kidney is normal, whereas clinical improvement in urinary drainage is regularly obtained. This improvement in drainage is poorly registered by renography. It is concluded that renography is an important complementary method to urography, but the method cannot replace the radiological methods in the follow-up of hydronephrosis surgery.

Adolescent↗
PubMed1975

Doxycycline levels in prostatic tissue and blood.

Doxycycline was administered orally to 23 patients scheduled for prostatectomy or radical cystectomy. Blood and prostatic tissue samples were collected simultaneously during operation and subsequently assayed for doxycycline levels. The concentration of doxycycline in the prostatic tissue was on average 2.75 mug/g which is far above the therapeutic level. The lowest level recorded was 0.85 mug and the highest was 4.81 mug. The findings suggest a tendency for this antibiotic to accumulate in prostatic tissue. This is in agreement with the clinical observations of the good effect of doxycycline treatment in patients with chronic bacterial prostatitis.

Administration, Oral↗
PubMed1974

[Cystometry].

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Diabetic Neuropathies↗
PubMed1973

[Renal cancer].

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Adenocarcinoma↗