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Biomedical subjects

W Matthiessen

Publications and source records attributed to W Matthiessen.

14 recordsLinked to original sources
PubMed1991

[Complications of pulmonary involvement in Bechterew's disease].

Fibrocystic changes in the upper lung lobes are a rare visceral manifestation of ankylosing spondylitis. The impaired bronchopulmonary clearance in bronchial, pulmonary or pleural cavities predisposes to secondary microbial colonisation. Two cases are reported--one patient proved to have non-tuberculous mycobacterial disease caused by M. kansasii, the other developed an aspergilloma.

Aspergillosis↗
PubMed1979

[A pilot and a controlled study of the influence of ethambutol on serum urate concentration and uric acid clearance (author's transl)].

Ethambutol is said to be capable of elevating serum urate concentration. This statement was reconsidered in three investigations using strictly supervised administration of ethambutol in a single daily dose of 25 mg. per kg. of body weight: (1) In short term administration 10 healthy subjects received ethambutol for eight days. (2) In a pilot study 13 patients suffering from pulmonary tuberculosis were treated with a triple combination including thambutol for six months. (3) In a controlled trial 23 patients were randomly allocated to one of the following regiments: In the first group patients received ethambutol plus isoniazid plus rifampicin for six months. In the second group patients received streptomycin plus isoniazid plus PAS for three months and thereafter streptomycin plus isoniazid plus ethambutol for another three months. Serum urate concentrations and clearances of uric acid and of creatinine were determined periodically in all subjects. A slight increase in serum urate concentration occurring in long term therapy showed no relation to ethambutol administration, but was obviously dependant on parameters related to the course of the disease in form of increase in body weight and physical activity, or related to the well known syntropy of chronic alcoholism and tuberculosis.

Alcoholism↗
PubMed1977

[Diagnosis of breast cancer metastatic to the chest (author's transl)].

The records of 100 patients with morphologically proven breast cancer metastatic to the chest retrospectively were analysed. The following manifestations were found by evaluating roentgenographs of the chest and available results of endoscopy and biopsy which were carried out in most of the cases: solid pulmonary coin lesion, multiple pulmonary coin lesions, lymphangiosis carcinomatosa, bronchostenosis caused by cancer, mediastinal lymph node metastases. Since life expectancy in approximatively 70 per cent can be increased by chemotherapy the authors put emphasis on the importance of early diagnosis of metastatic breast cancer disseminated to the chest.

Breast Neoplasms↗