Biomedical subjects
Publications and source records attributed to W Mayer.
Only a few cases of anterior chamber epithelialization after penetrating keratoplasty have been reported, and in most of these the keratoplasty had been preceded by another event that could have been the cause of the process. In the patient whose case we are reporting here, epithelialization of the anterior chamber developed after penetrating keratoplasty.
The incorporation of labelled carbon from glucose U-14C into CSF amino acids was investigated in three patients with Parkinson's disease and in three control persons with comparable age and physical stature. Comparing the specific radioactivities of serum and CSF one can postulate that the labelled amino acids found in the CSF are synthesized mainly by brain tissue. The resorption of glucose into the CNS and therefore the synthesis of amino acids from glucose was more rapid in controls; labelled alanine and glutamine appeared later in the CSF of the patients. As expected, in the controls the specific radioactivity of glutamic acid was found to be higher than that of glutamine, in patients the labelling of glutamine was higher as was that of serine, glycine, aspartic acid and asparagine. From our knowledge concerning the compartmentation of the metabolism of glutamate, we assume that in Parkinsonism the metabolic activity of neurons is reduced but that of astroglia is enhanced.
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The importance of the scleral buckling technique without vitrectomy is discussed with reference to a patient with aphakia, myopia and morning-glory redetachment. In this almost hopeless situation, scleral buckling surgery was performed. The culyx of the periretinal membranes was opened without vitrectomy and in spite of massive vitreous body shrinkage. After surgery the retina attached almost completely and the patient's visual acuity improved from light perception to 0.06. His present condition is illustrated by sketches and photographs of the fundus. The value of the method is emphasized by reference to similar cases. The patient, who also underwent retinal detachment surgery on the fellow eye and had been pensioned, is now following his occupation again.
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The concentration of guanidine was determined in blood serum and urine of healthy humans following oral administration of guanidine hydrochloride. The biological half life is 12 h, the renal clearance is 40--50 ml. An improved method for the determination of guanidine in body fluids is described.
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A computer analysis of 87 penetrating kertoplasties done in a uniform manner by a single surgeon revealed the following: 1. On a statistical basis small grafts (7.0 mm) provided better visual acuity than larger grafts (8.0 mm). 2. On a statistical basis small grafts will be clearer postoperatively than larger grafts. 3. On a statistical basis the age of the donor is not related to either graft clarity or visual acuity.
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Using a random selection procedure, 100 patients were evaluated in order to determine the value of prophylactic antibiotics in cesarean section. All patients were evaluated for febrile morbidity, and specific infection sites were recorded. Significant differences were found between the treated and control groups and between cesarean sections performed prior to the onset of labor and after the onset of labor.
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