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Biomedical subjects

W Mazurowski

Publications and source records attributed to W Mazurowski.

At least 19 recordsLinked to original sources

Meningiomas and gliomas in juxtaposition: casual or causal coexistence? Report of two cases.

Two cases of meningioma and glioma established in biopsy material from one or more than one operation are reported. In these cases, an originally benign meningioma was followed by the development of anaplastic astrocytoma in close juxtaposition to the site of first operation. The close juxtaposition of two histologically different tumors suggested that one of them might lead to local proliferation and independent growth of the other.

Brain Neoplasms

Microcystic meningioma--a rarely occurring morphological variant of meningioma.

Two cases of microcystic meningioma are reported. They were found by retrospective study of 124 human intracranial meningiomas. Both of the examined tumors were characterized histologically by a great number of cysts of various size intermixed with nests of neoplastic tissue of meningothelial meningioma type. Nevertheless, there were two kinds of cystic changes in these tumors. In the first case, numerous microcysts within the tumor were surrounded by stellate-shaped processes of meningioma's cells. The microcystic space were empty or rarely contained eosinophilic material. The latter tumor demonstrated small agglomerations of microcysts and many macrocystic changes, some of them filled with eosinophilic, PAS and mucicarmine negative material. Additionally, in focal areas of the tumor, single mitotic figures and giant cells with hyperchromasia were present. The authors discuss morphologic variability of the examined tumors and its possible clinical consequences. The pathogenesis of microcystic changes in meningioma is discussed with a brief review of the literature.

Adult

[Transplantation of fetal dopaminergic cells in Parkinson disease].

Four patients with severe form of Parkinson's disease received transplantation of fetal dopaminergic cells into the caput of the caudate nucleus. The operation was done by an original method using a device designed specially for this purpose. In all cases the duration of the disease was 10 to 15 years, and the predominating signs were tremor, bradykinesia, and markedly pronounced side effects of the treatment (on-off syndrome and involuntary movements). One patients died 5 weeks after the operation. Autopsy demonstrated good survival of the transplanted cells with good integration with the brain of the recipient and traces of positive immunocytochemical reaction for tyrosine hydroxylase. In the other patients a significant clinical improvement was noted after the operation, with reduced intensity of parkinsonian symptomatology, shortening of the duration of the off phase, improved motor ability and reduced intensity of the involuntary movements. The longest follow-up was 24 months.

Brain Tissue Transplantation

[Extensive bifocal location of ependymoma of the spinal cord].

Spinal cord ependymomas belong to rare tumours of the central nervous system. Their malignancy is usually low although anaplastic forms are known also to occur. Surgical treatment is the method of choice supplemented often with radiotherapy. An exceptionally rare form of ependymoma with two foci of origin in the spinal cord is reported. The large extent of the tumour caused that laminectomy at 15 levels was necessary. The mechanism of ependymoma development at two levels is discussed.

Adult

[Favorable outcome of decompression of the trigeminal nerve in a case of bilateral neuralgia].

A case of the bilateral trigeminal neuralgia produced by compression of the V cranial nerve roots by the branch of the anterior lower cerebral artery and post-hemorrhagic aggregates is presented. Complete recovery was obtained in the result of 2-stage, intracranial relief of the right and left trigeminal nerve roots. Neurologists share the opinion that intracranial surgical relief of the V cranial nerve root produces favourable result in case of trigeminal neuralgia resistant to pharmacotherapy.

Arteries

[Microsurgical treatment of cerebral arteriovenous aneurysm].

The authors describe a group of 9 patients with arteriovenous malformations of the brain operated upon using the microsurgical technique and controlled arterial hypotension. In all cases the malformations were radically removed. In one patient the neck of a coexistent aneurysm of the pericallosal artery was clamped with a clip. Disability in one patient was the effect of haemorrhage, another patient with hemiparesis is being rehabilitated. The remaining patients are feeling well and in only one of them epileptic seizures remained after the operation, they had, been however, present before the operation. The use of the microsurgical technique makes possible reduction of the surgical trauma to the brain tissue and opens greater possibilities of intraoperative evaluation of radical performance of the operation.

Adolescent