PubMed Health⌕ Search

Biomedical subjects

W McGregor

Publications and source records attributed to W McGregor.

At least 37 records · Page 2Linked to original sources
PubMed1986

Effect of imidocarb dipropionate prophylaxis on the infectivity and immunogenicity of a Babesia bovis vaccine in cattle.

Imidocarb dipropionate (IDP), a potent prophylactic drug against Babesia bovis infections in cattle, was tested for its effect on the infectivity and immunogenicity of a live B. bovis vaccine marketed in Australia. At the recommended prophylactic dose rate of 3 mg/kg, IDP suppressed infectivity of the vaccine for at least 6 weeks. The vaccine infected all cattle inoculated either 8 weeks after treatment with 3 mg/kg, or 4 weeks after treatment with the recommended therapeutic dose of 1.2 mg/kg. These infections were, however, partially suppressed and the level of immunity to a subsequent heterologous virulent challenge was reduced. Cattle that failed to become infected after vaccination were fully susceptible to the challenge. It is concluded that where B. bovis vaccination is contemplated, prophylactic use of IDP should be avoided.

Animals↗
PubMed1985

New compound curved needle TG6-C PLUS.

The benefits of a compound curve needle design will be seen readily when used as suggested. The surgeon will be able to position the needle repeatedly and accurately between the wound edges from needle entry through tissue, to exit to the opposite side of the wound. Continuous or interrupted corneal wound closure can be done consecutively without varying more than a few tenths of a millimeter in the positioning of the needle from bite to bite. During retrieval the compound curve needle has yet another advantage. The flat curve of the distal needle body minimizes the tissue distortion as the needle body is pulled through. The wound remains in close apposition. In wound closure, though an important and essential attribute of a surgical needle is its "sharpness", sharpness eventually reaches a maximum. The very sharp needles such as the new EthiconTM TG PLUS needles, have such little tactile feedback that shape and needle strength as exemplified by the compound curvature design become of primary importance. These combinations provide the consistent and accurate needle passage necessary for corneal wound apposition, with all of its optical as well as anatomic consequences, in the final outcome of contemporary keratoplasty and cataract procedures.

Cornea↗
PubMed1982

A microplate enzyme immunoassay for detecting and measuring antibodies to Babesia bovis in cattle serum.

A microplate enzyme immunoassay (EIA) is described for measuring IgG antibody to Babesia bovis in cattle serum. B. Bovis antibody status (whether positive or negative) and the amount of B. Bovis antibody (EIA score), were measured by comparison with reference serums. The EIA was shown to be specific for B. Bovis, and EIA score correlated well with EIA titre. Comparison of EIA with the Indirect Fluorescent Antibody Test (IFAT) showed more than 95% agreement between the methods and disagreement in only 1.6% of serum samples tested. The remaining 3.2% were positive by EIA and suspected positive by IFAT. The EIA was shown, by titrating positive serums, to be more sensitive than IFAT, which explained its tendency to detect more positive serums than IFAT. EIA detected B. bovis antibody in experimentally infected cattle by day 14 post infection (pi) and for at least 268 days pi. EIA score for B. bovis antibody in immune cattle increased significantly (p less than 0.05) following heterologous strain challenge.

Animals↗
PubMed1981

Development of a highly infective Babesia bigemina vaccine of reduced virulence.

The virulence of a strain of Babesia bigemina was reduced by syringe passaging at 3 to 16-week intervals in a series of 7 calves. The calves were splenectomised 1 to 14 weeks after inoculation to induce the relapse parasitaemias used for passaging. Parasites taken at relapse from the last 3 calves in the series were inoculated into splenectomised calves from which highly parasitised blood for vaccine was obtained. The vaccine produced mild infections in 32 recipient cattle. When challenged either 5 weeks or 7 months after vaccination, the cattle had substantial immunity to a heterologous strain of B. bigemina.

Animals↗
PubMed1979

Evaluation of an indirect fluorescent antibody test to diagnose Babesia equi infection in horses.

An indirect fluorescent antibody (IFA) test for the diagnosis of Babesia equi infections was evaluated. Antigen prepared by conventional methods was of high quality in one instance and of lesser quality in a second when possible autofluorescence of the horse blood caused inconvenience in reading tests. Tests on 14 horses shown by parasitological means to be either infected (9) or uninfected (5) produced reactions at dilutions of 1/270 to 1/7290 for infected and at 1/10 to 1/90 for uninfected animals. The accuracy of the test was further demonstrated during investigations of 701 horses in 3 states of Australia. The 30 horses reacting at 1/270 to 1/2430 were from 33 imported to 3 different farms in Australia from a common source. Investigations of crossreactivity between B. equi and B. bovis of cattle suggested that B. bovis would not interfere with the test for B. equi, but that the reverse was possible.

Animals↗
PubMed1977

Biological differences between African Theileria mutans (Theiler 1906) and two benign species of Theileria of cattle in Australia and Britain.

Serological and morphological comparisons between the theilerias found in Australian and British cattle and of these with African Theileria mutans (Theiler 1906) showed that the Australian and British parasites were similar to each other but different from T. mutans. Further investigations are required to determine taxonomic affinities between the Australian and British theilerias and T. sergenti, a similar parasite found in eastern Asia.

Animals↗
PubMedDate not supplied

Influence of cutting edge configuration on surgical needle penetration forces.

A standardized test for measuring the needle penetration forces has been developed that can be easily replicated in any laboratory. Using this test, conventional cutting edge needles utilized in the test produced lower penetration forces than reverse cutting edge needles. The lower penetration forces encountered by the conventional cutting edge needles imply that the physician should be able to handle these needles with more dexterity and precision than the reverse cutting edge needle.

Membranes, Artificial↗
PubMedDate not supplied

Emergency physician's needle holder.

A new needle holder is described that has jaws metallurgically bonded with tungsten carbide particles that enhance needle holding security without causing sutural damage during instrument ties. Scissors have also been incorporated into the needle holder to cut sutures. One ringlet on a handle has been offset to facilitate retrieval of the needle holder from a flat surface.

Emergency Medicine↗
PubMedDate not supplied

A new compound curved needle for intradermal suture closure.

A new compound curved needle has been designed and developed for intradermal suture closure from a unique stainless steel alloy, American Society of Testing Materials (ASTM) 45500. This needle has a short, straight, sharpened point with a reverse cutting edge, followed by a curved distal section. Despite its geometry, it exhibited a similar resistance to bending and breakage as did a curved needle with a single radius of curvature manufactured from the same alloy. The design of this new needle enabled the physician to pass it through the dermis with a greater accuracy to a controlled depth and length of bite than curved cutting edge needle with a single radius of curvature.

Clinical Trials as Topic↗
PubMedDate not supplied

Biomechanics of a new atraumatic surgical needle holder.

It is the purpose of this report to design, develop, and evaluate a needle holder whose jaws improve needle-holding security without altering the geometry of the curved surgical needle. The configuration of the jaws of this new needle holder is curved, conforming to the curvature of the surgical needle. A biomechanical study of this curved surgical needle holder demonstrates that it holds the curved needle securely without needle deformation.

Biomechanical Phenomena↗
PubMedDate not supplied

Mechanical performance of disposable surgical needle holders.

The mechanical performance of disposable Webster surgical needle holders supplied by three different surgical instrument companies was determined by recording the forces (clamping moment) applied by the different needle holder jaws to curved surgical needles. This investigation demonstrated that there was a large variability in the mechanical performance of the disposable needle holders supplied by each surgical instrument company. In addition, the mechanical performance of the disposable needle holder of each surgical instrument company was distinctly different.

Disposable Equipment↗