Prenatal diagnosis of lipomyelomeningocele.
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Biomedical subjects
Publications and source records attributed to W McGrew.
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We have described three patients with heterotopic gastric mucosa of the proximal esophagus, which has been recognized by pathologists since the early 19th century. In contrast to Barrett's esophagus, which is now known as an acquired metaplastic lesion of the esophagus, this mucosa is believed to be a remnant of incomplete epithelialization of the esophagus during fetal life. It has little clinical significance because of the small size of the mucosal patch and the neutralization of the acid by saliva.
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Jejunal diverticulosis, a marker of disordered small intestinal motility, presents varied clinical manifestations. It is important to consider this disorder in elderly patients with unexplained abdominal discomfort accompanied by signs of intermittent small bowel obstruction and malabsorption. Diagnosis can be made by a small bowel follow-through x-ray film obtained as part of the evaluation of diarrhea and obstructive symptoms. Medical therapy is helpful in controlling diarrhea and anemia, while surgical therapy can give excellent results in treating complications or refractory symptoms.
Patients with portal hypertension due to cirrhosis commonly have bleeding from varices. In patients with a total colectomy, ileal varices can be a site of bleeding in cases of portal hypertension. Proper diagnosis requires studying the venous phase of the mesenteric arteriogram to show ileal varices, and carefully inspecting the mucocutaneous region of the ileal stoma for venous bleeding sites. Bleeding from ileal varices can be managed by either local control or portal vein decompression.
Colonic lipomas are uncommon tumors but do constitute the most common nonepithelial tumor of the gastrointestinal tract. They tend to occur in an older population and rarely cause symptoms. However, if a lipoma discovered by barium enema or colonoscopy is causing symptoms of obstruction or bleeding, the tumors may require surgical removal. Rarely, as in our patient, the bleeding lipoma may be sufficiently pedunculated to allow safe colonoscopic removal. In general, lipomas of the colon are curiosities that must be distinguished from adenomatous polyps.
This report demonstrates that hepatic metastases can present with fulminant hepatic failure and that liver enzyme abnormalities may not become prominent until there has been massive replacement of the liver. The CT scan of liver may not demonstrate diffuse liver metastases as seen in this patient. Merkel cell tumor or trabecular neuroendocrine skin tumor is a previously unreported cause for the development of the syndrome of hepatic failure due to liver metastases.
Endoscopic sclerotherapy is used to obliterate esophageal varices in an attempt to decrease bleeding episodes. First reported in the 1940s, sclerotherapy has recently enjoyed renewed interest because surgical shunting procedures, though effective in preventing rebleeding, are associated with significant mortality and provide no increase in long-term survival. Sclerotherapy, using a flexible endoscope, has been used in 30 patients at Vanderbilt University and the VA Medical Center, Nashville, Tenn. We present our clinical experience, compare our results with those of other groups, and discuss other approaches to the management of bleeding varices.
We have reported two cases of double pylorus or duplicated pyloric channel as an unusual complication of peptic ulcer disease. It is usually noted as an incidental finding on x-ray films or at endoscopy. Double pylorus seems to be an acquired lesion arising from gastric ulceration and does not necessarily require surgical correction.
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