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Biomedical subjects

W Meinhof

Publications and source records attributed to W Meinhof.

At least 19 recordsLinked to original sources
PubMed1991

[The control of storage mites in the mycological laboratory].

Mycological cultures in the laboratory are threatened by storage mites who feed on fungi and cause contamination by transferring bacteria and fungi from culture to culture. To eliminate mites from fungal cultures without damage to the fungi themselves several chemical and physical procedures were tested. The following substances were added to Sabouraud glucose (2%) agar at concentrations of 0.1 and 1.0%: gamma benzene hexachloride (lindane), N-ethyl-o-crotonyltoluide, pyrethrins, dieldrin N,N-diethyl-m-toluamide, benzyl benzoate, and--as popular household remedies--Eau de Cologne, neutral soap and garlic. The media were inoculated with 4 dermatophytes (T. rubrum, T. mentagrophytes, M. gypseum and E. floccosum). Two to three weeks later the fully grown cultures were contaminated with mites and their eggs. In other test series, mite infested cultures were exposed to heat (40 degrees C and 60 degrees C) or cold from -12 degrees C to -28 degrees C over different periods of time. Finally, the protective value of sealing culture dishes with adhesive tape was investigated. The most useful method to control mite infestation in fungal cultures seemed to be exposure to heat over a short time.

Animals↗
PubMed1989

[Differential diagnosis of tinea manus and tinea pedis].

Dermatophytoses of hands and feet may appear under a variety of different clinical pictures which can easily be mistaken for other skin diseases. The degree of acute or chronic inflammation and of a disturbed keratinization determines if vesicle or pustule formation, scaling, hyperkeratosis or maceration are predominant features of a tinea manus or tinea pedis. Several examples of similar clinical manifestations e.g. eczema, psoriasis, lichen planus, are given. It is stressed that direct microscopy and culture of the fungus are prerequisites of a correct mycological diagnosis.

Diagnosis, Differential↗
PubMed1989

Incidence of oral candidosis.

Although it is well known that both yeasts in general and Candida albicans in particular are frequently found in the oral cavity of ill and even of healthy individuals, the definite incidence of oral candidosis is far from being clear. Today it is, however, possible to assess the frequency of oral candidosis in a country indirectly, judging from the frequency of prescription of drugs for this indication. Data thus obtained indicate a remarkable increase of the frequency of the disease during the last decade. While polyenes are still prescribed for oral candidosis about as often as ever, the prescription of azoles has gained more and more importance.

Age Factors↗
PubMed1987

Occurrence of HPV genomes in penile smears of healthy men.

Penile smears of 530 males without any clinically detectable genital papillomavirus infection were subjected to molecular in situ hybridization on filters with different 32P-labeled HPV-DNAs. HPV genomes were identified in 31 cases (5.8%). Eight smears reacted with HPV 6/HPV 11 DNA and 5 specimens with HPV 16 and HPV 18 DNA exclusively; in 18 cases HPV 6/HPV 11 and HPV 16/HPV 18 were found in coexistence. With regard to the different age groups, HPV-DNA was found in only 1.7% of smears obtained from persons over 35 years of age, while 7.9% of the samples from men aged 15 to 35 gave positive results. This age distribution indicates that the occurrence of HPV genomes in epithelial cells of the glans may be due to infections by sexual contact rather than to reactivation of persisting viruses.

Adolescent↗
PubMed1979

[In vitro investigations of microphages function in patients with chronic mucocutaneous candidosis (author's transl)].

In five patients with either familial or non-familial type of chronic mucocutaneous candidosis some properties of phagocytic function of the polymorphonuclear leucocytes (PMNL) have been studied in vitro. In each of the patients there were found: a) a decreased chemotactic activity of PMNL, b) a weakness of intake and of intracellular destruction of Candida albicans cells by PMNL, c) an impairment of phagocytosis and intracellular killing of Candida albicans as well of Staphylococcus aureus by PMNL. The rate of phagocytosis of heat-inactivated Candida albicans cells by PMNL was normal in each case. In the serum of two patients a phagocytosis inhibiting factor is supposed to exist. In PMNL of 3 patients a defective activity of NADH-dependent oxidase was found. The occurrence of hereditary CMCC in a father and his two daughters points to an autosomal dominant trait, whereas in most cases of familiar CMCC hitherto described an autosomal recessive mode of transmission was found.

Adult↗
PubMed1979

[Present state of antimycotic therapy (author's transl)].

In the local treatment of various forms of dermatophytosis tolnaftate used to be the most convincing drug. More recent developments have led to a group of imidazol derivatives which have a broader spectrum and are also effective against yeasts. Polyene antibiotics are still very useful in the treatment of Candida mycoses. There are only few drugs available for systemic treatment of mycoses. Grisefulvin is only effective against dermatophytes. Amphotericin B, given intravenously, is a very useful drug against a series of systemic mycoses but it's value is decreased by serious side effects. Fluorocytosin shows less unwanted effects than Amphotericin B, but many fungi are resistent against this antimycotic or may become so during treatment. Of the imidazol group only miconazole is available for systemic intravenous therapy. Further developments of systemic antimycotics are of great importance.

Amphotericin B↗
PubMed1978

[Dermatophytoses which may be easily misinterpreted].

Almost absent inflammtory reaction or unusually deep inflammation can lead to atypical varieties of dermatophytoses. Some of the more common varieties of this kind are briefly portrayed. The importance of mycological examination, both microscopic and cultural, is pointed out.

Culture Media↗
PubMed1978

[Morphological variants of folliculitis barbae candidomycetica].

Report on two cases of folliculitis barbae candidomycetica (f.b.c) which mimicked impetigo contagiosa in one case and tinea barbae in the other. Both patients suffered from typical predisposing factors such as leukemia, cytostatic and corticosteroid therapy, and diabetes mellitue. Taking into consideration the morphology of cases described earlier in this journal, three types of f.b.c. can be recognized: folliculitis simplex-like type, tinea barbae-like type and impetigo-like type.

Candidiasis, Cutaneous↗
PubMed1977

[Levamisole in the treatment of therapy-resistant folliculitides].

Report on two cases with chronic folliculitis of the face, resistant to antibiotic therapy. In both cases Staphylococcus epidermidis was the only organism that could be isolated. After a comparatively short treatment with levamisole (150 mg on two successive days weekly) the lesions cleared completely.

Adult↗