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Biomedical subjects

W Mello

Publications and source records attributed to W Mello.

9 recordsLinked to original sources
PubMed2005

Ultrastructural changes on the hard palatine mucosa of Calomys callosus after 120 days of experimental chronic alcoholism.

The present study analyzed the toxic effects of chronic alcohol ingestion on the ultrastructure of the lining epithelium of the hard palatine mucosa of the rodent Calomys callosus, in order to contribute to the understanding of the consequences of alcohol abuse for the morphology of the digestive system. Twenty-six adult animals aged three months were divided into two experimental groups. The control group received a solid diet and tap water, and the alcoholic group received the same solid diet and ethanol P.A. diluted 20% in water (v/v). After 120 days of treatment, all animals were anaesthetised, weighed and sacrificed. At the end of treatment, mean body weight did not differ between control and alcoholic animals. The epithelial cells of the alcoholic group showed many alterations such as the presence of lipid droplets, nuclei in corneum layer, nuclei with increase peripheral chromatin and greater electron density, altered mitochondria, and intense dilatation of the intercellular spaces. It was concluded that 20% ethanol provokes marked ultrastructural lesions in the hard palatine mucosa.

Alcoholism↗
PubMed1998

Ultrastructural study of the lateral lobe of the prostate of Wistar rats submitted to experimental chronic alcohol ingestion.

Alcoholism is considered today one of the most serious social and medical problems. Different investigators have demonstrated that chronic exposure to alcohol causes morphological and physiological changes in the testes and in the accessory sex glands, in the prostate in particular. In the present study, experimental rats were divided into groups receiving sugar cane brandy diluted to 30 degrees G.L. (30%, v/v) and Purina ration ad libitum for 60, 120, 180, 240 and 300 days, respectively. At the end of each period the animals were sacrificed and the lateral lobe of the prostate was collected for histological examination. The results showed atrophied epithelium, accumulation of lipidic droplets and rupture of the microvilli that line the cell surface facing the lumen of cells of the secretory epithelium of the lateral lobe of the prostate.

Alcoholism↗
PubMed1991

Popliteal cyst: a surgical approach.

Twenty-nine adult patients (30 knees) who failed conservative treatment had surgical excision of a non-rheumatoid cyst. To determine the effectiveness of this surgical procedure, we reviewed the cases of 24 patients (25 knees) who were available for subjective and objective follow up. Twenty of the 25 knees (80%) were rated excellent or good. Three knees had fair results. Two knees continued to have problems and ultimately underwent total knee replacement for degenerative arthritis.

Adolescent↗
PubMed1983

The effect of the filling material in the tissue reactions following apical plugging of the root canal with dentin chips. A histologic study in monkeys' teeth.

The object of the present work was to observe whether the root canal filling material has some influence in the periapical healing process after apical plugging with dentin chips. Monkeys' teeth were filled with nine different filling materials in use today. Ninety days after the treatment, the histologic data showed no differences in the results with the nine materials studied. This fact suggests that the filling material does not influence the healing process when the plug is present.

Animals↗
PubMed1980

Apical hard-tissue deposition in adult teeth of monkeys with use of calcium hydroxide.

The periapical tissues of adult teeth of monkeys were examined histologically after root canal treatment with calcium hydroxide. Healing, as evidenced by complete apical closure with a hard tissue bridge and an inflammation-free periodontal ligament, occurred more frequently where canals were instrumented 1 mm short of the apex. Overinstrumented canals exhibited a significantly decreased incidence of apical closure.

Animals↗
PubMedDate not supplied

[Human papillomavirus associated with uterine cervix lesions].

It was studied the prevalence of human papillomavirus (HPV) among 228 women with lesions of uterine cervix attending the Ofir Loiola Institute, in Belem, Para, from March 1992 to May 1996. Histopathological examination was performed with all cervical biopsy samples obtained from these patients. In addition, specimens were analysed by both polimerase chain reaction and dot-blot hybridization to detect HPV DNA. The patients were assigned to three groups, according to the diagnosis made by histopathology, as follows: A, including 155 women suffering from invasive epidermoid carcinoma or adenocarcinoma; B, 54 patients having either cervical intraepithelial neoplasia grade II or III; and C, involving 19 women with chronic cervicitis. The prevalence rates of HPV in groups A, B and C were 70.3%, 63% and 36.8% respectively. HPV 16 accounted for 60.4% and 54.5% of types identified in groups A and B, respectively. Altogether HPV types 16, 18 and 33 were detected in 71.4% of positive patients belonging to group C.

Biopsy↗