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Biomedical subjects

W Meredith

Publications and source records attributed to W Meredith.

8 recordsLinked to original sources

Blood pressure and intellectual functioning in late midlife.

To determine how much change in cognitive performance can be attributed to blood pressure status, 103 adults were assessed on two occasions approximately 11 years apart. Subjects' ages ranged from 49 to 63 years on the second occasion. Regression analyses were performed to determine how much variance in change in performance on the Digit Span, Block Design, Object Assembly, and Digit Symbol tests was accounted for by blood pressure status. Time 1 and Time 2 diastolic blood pressure, and change in hypertension medication significantly predicted Time 2 performance on the Digit Span Forward test even after Time 1 test performance, age, education, and gender were accounted for. The results further confirm the importance of assessing health functioning when studying age-related changes in cognitive performance.

Aging

Vascular injuries in a rural state: a review of 978 patients from a state trauma registry.

The demographics, etiology, and outcome of 1148 vascular injuries suffered by 978 patients reported from eight trauma centers in a largely rural state to a trauma registry (NCTR) data base containing 26,617 patients entered over a 39-month time interval were analyzed. Vascular injury patients were more frequently transferred by helicopter (18%), referred from other hospitals (45%), transfused more blood (8 units mean/24 hours), had higher mean ISS values (14 vs. 9), had lower systolic blood pressures on admission (113 vs. 128 mm Hg), had higher emergency department mortality (3.3%), and required immediate surgery more often (79%) when compared with nonvascular injury NCTR patients (p = 0.0001). Vascular injury patients had significantly longer hospital stays (13 vs. 10 days), longer ICU stays (5 vs. 4 days), and greater hospital costs ($22,500 vs. $12,300) while incurring more serious AIS values for the regions of the chest, abdomen, and extremities. One hundred twenty-nine (13.1%) died, 97 after admission compared with a 6.2% mortality for NCTR nonvascular injury victims. Forty-seven percent of vascular injuries were extremity lesions; the amputation rate was 1.3%; and management was most often by simple repair (41.9%) or patching (22.2%). Rural vascular injury patients had a high incidence of blunt trauma (43.4%) and were older (average, 51 years); they were transported by helicopter more often (30.3%) and were frequently referred from another hospital (77.8%); they had longer ICU, ventilator, and hospital stays and greater hospital charges; and they had higher mortality (14.2%) compared with urban vascular trauma victims. The data suggest a need for the trauma care system to focus on earlier recognition, stabilization, and rapid transportation of this most seriously injured group of patients.

Age Factors

Comparison of the ability of adult and pediatric trauma scores to predict pediatric outcome following major trauma.

The Pediatric Trauma Score (PTS) has been identified as the only accurate and adequate means of predicting outcome in pediatric trauma. In answer to the increasing number of trauma patients arriving at local hospitals, the ability of the adult Trauma Score (TS) to predict pediatric trauma outcome was tested. Of the total 2,604 pediatric trauma cases in the North Carolina State Trauma Registry, 441 had both a PTS and TS available for analysis. The primary measures of outcome were emergency department and hospital dispositions. Logistic regression demonstrated that TS (R2 = 0.50) was a stronger predictor of pediatric outcome and PTS (R2 = 0.35) for emergency department disposition and TS (R2 = 0.63) with PTS (R2 = 0.51) for hospital disposition. The correlation between TS and PTS was high (R = 0.8). Stepwise discriminant analysis demonstrated that TS was the stronger predictor of outcome and the PTS added only 9% (partial R2 = 0.09) more accuracy to TS for emergency department disposition and only 6% (partial R2 = 0.06) for hospital disposition. The results of this research demonstrate that TS is a useful method of predicting outcome in pediatric trauma. The use of both scores for each patient does not increase the predictive value of the scores.

Adolescent

The spectrum of abdominal injuries associated with the use of seat belts.

Several recent reports have described abdominal injuries occurring as a result of seat belt use, raising concerns about seat belts as an agent of injury in motor vehicle crashes. The purpose of this study was to characterize the distribution of abdominal injuries after motor vehicle crashes in belted and unbelted patients admitted to trauma centers. The mortality was higher in unbelted than belted patients (7% vs. 3.2%, respectively, p less than 0.0001). Unbelted patients also had significantly more frequent and more severe head injuries (50.0% vs. 32.9%, respectively, p less than 0.001). The incidence of abdominal injury was equal in both unbelted patients (13.9%), but the spectrum of organs injured was different in the two groups. Gastrointestinal tract injuries (stomach, small bowel, colon and rectum) were significantly more frequent in belted vs. unbelted patients (3.4% vs. 1.8%, respectively, p = 0.001). The frequency of liver and spleen injuries was the same in both groups. This study demonstrates that in patients admitted to trauma centers after motor vehicle crashes, belted and unbelted patients have an equal incidence of abdominal injury, but belted and unbelted patients have a different spectrum of injuries. Hollow viscus injuries are more common in belted crash victims. Seat belt use was associated with significantly fewer head injuries and deaths. Physicians evaluating trauma victims after motor vehicle crashes should be aware of the fact that the types of abdominal injuries may vary substantially depending on seat belt use.

Abdominal Injuries

Change and stability in adult intellectual functioning assessed by Wechsler item responses.

Change in adult intellectual performance was assessed with longitudinal data from the Intergenerational Studies at the Institute of Human Development. Wechsler Intelligence data from two age cohorts spanning ages 18 to 61 were analyzed at the subtest and item level. Hotelling T2 analyses on sets of equivalent items from Wechsler subtests were studied to determine if change in response occurred between pairwise combinations of occasions of test administrations. We used Bowker's test to analyze data at the item level to determine the direction of change in performance. Consistent improvement in performance occurred between the ages of 18-40 and 18-54. Between the ages of 40 and 61, results showed mostly improved performance on the Information, Comprehension, and Vocabulary subtests, mixed change on the Picture Completion subtest, and decline on the Digit Symbol and Block Design subtests. The pattern of mixed change on the Picture Completion subtest indicated improvement on the easy items and decline on the difficult items. Decline in performance on the Block Design test occurred only for the most difficult items.

Adolescent

Effects of sensory and motor functioning on adult intellectual performance.

This study examined longitudinal health and intelligence data to determine whether sensory or motor deficits account for some of the age-related intellectual changes that are commonly seen from midlife onward. Although sensory and motor functioning did not account for the age-related decrements in performance on speeded, visual perceptual tasks found for this sample in previous work, we did find that hearing deficits added error variance to performance estimates on two verbal subtests of the Wechsler scales.

Adult

A longitudinal study of spatial ability.

A number of studies have lent support to the sex-linked major gene theory of spatial ability. Expectations arising from this theory (although not necessarily unique to it) are that spatial ability can be measured in children, that it is the same as spatial ability in adults, and that an individual's position in a distribution of spatial ability remains unchanged over time. Results of a longitudinal experiment utilizing test scores of 76 high school students and their earliertest scores provide confirmatory evidence for these expectations.

Adolescent

Component analysis in multivariate aging research.

A method of components analysis, related to principal components analysis, is described for applications in multivariate cross-sectional or longitudinal data. The method may be useful to researchers seeking to reduce the number of observed variables through scale construction. The method creates component variables as weighted sums of the observed variables using weights that are identical across groups and occasions. The statistical and conceptual properties of these components are discussed. The method is contrasted with traditional principal components analysis and factor analysis. An application of the method is presented using longitudinal WAIS and WAIS-R data.

Cross-Sectional Studies