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Biomedical subjects

W Mischke

Publications and source records attributed to W Mischke.

At least 19 recordsLinked to original sources
PubMed1997

[5 years quality assurance in accordance with the roentgen regulation. Benefits, costs, necessary innovations].

Guidelines and standards supplementing the German "Röntgenverordnung" initiated a complex system of quality control in diagnostic radiology. Cost and profit are analysed for two hospitals of comparable size (Klinikum Buch and Klinikum Nürberg). The considerable expenses that must be incurred for measuring devices, equipment, working time and extra charges on the one hand, are the items that are opposed to achieving a higher image quality and dose reduction on the other. Public quality control enables to demonstrate the quality and to optimise imaging procedures in diagnostic radiology. A critical evaluation of the results of quality control suggests further developments. We should consider larger time intervals for quality tests in some cases, while focussing on techniques with high radiation exposure, e.g. computed tomography, where dose reductions are highly effective.

Adolescent↗
PubMed1991

[Reoperations in primary hyperparathyroidism].

We report on 14 patients suffering from persistent (n = 13) and truly recurrent (n = 1) primary hyperparathyroidism. Reoperations were successful in 13 cases. Cervical reexploration was only required for 5 patients who had previous operations by unexperienced surgeons in other clinics. In 5 out of 7 patients operated by us, the causes of the persistent primary hyperparathyroidism were 4 adenomas and one hyperplastic gland in the mediastinum found by median sternotomy. The remaining cases were a rare ectopic location of the inferior glands and an inadequate resection in four-gland-hyperplasia. Preoperative localization procedures were carried out for most patients. 201-Tl/99m-Tc-subtraction scintigraphy has proved for localization in both the cervical region and the mediastinum to be a highly sensitive method. Reoperative parathyroid surgery can be reduced with thorough initial cervical exploration by experienced surgeons in specialized clinics.

Adenoma↗
PubMed1981

[The problem of intensive care of premature and newborn infants (author's transl)].

Today there is a controversy about the demand for the preservation of human life at any price. Special difficult problems result from intensive care of premature and newborn infants. The clinical criterions of cerebral death are different to those of adults, special investigations are restricted in their application. Often you cannot be sure of the prognosis in spite of knowing the diagnosis. Should the competent parents decide with us about the renunciation of a -- further -- intensive care? It is necessary to value all available factors to take the right decision. The paper wants to inform about some important criterions and stimulate the discussion.

Brain Death↗
PubMed1980

Short-term response of testosterone, dihydrotestosterone, 5 alpha-androstane-3 beta, 17 beta-diol, testosterone-glucosiduronate and estradiol-17 beta as measured in the spermatic vein of human male subjects after infusion of gonadotropins.

In 8 male subjects with normal testicular function, blood was drawn from the left spermatic vein and from the right cubital vein before and during an infusion of 4,000 IU human chorionic gonadotropin (hCG) (preceded by a bolus of 1,000 IU) or of 500 IU hCG plus human menopausal gonadotropin (hMG), respectively, within 30 min. Testosterone levels in the spermatic vein blood increased rapidly up to 518 or 215%, respectively. An increase of estradiol-17 beta and of 5 alpha-dihydrotestosterone concentrations in spermatic vein blood was observed only in 1 and 2 subjects, respectively. It was shown that the human testicle releases also 5 alpha-androstane-3 alpha, 17 beta-diol and testosterone-glucosiduronate. Both steroids did not respond to the short-term infusion of gonadotropins. The same holds true for all five steroids measured in peripheral vein blood.

Adult↗
PubMed1979

Terminal Ph1-positive monocytic crisis in chronic myeloid leukemia providing evidence for the promyelocytic origin of monocytes.

A case of Ph1-positive chronic granulocytic leukemia in described in which a terminal monocytic crisis developed. The case still was Ph1-positive at the time of the monocyte crisis. Bone marrow smears contained promyelocytes and early granulocytes, but most of the cells belonged to the monocyte series as cytochemistry disclosed. No blast cells could be detected. Cytochemically, transitions between promyelocytes and promonocytes could be demonstrated. From these findings and those from the literature it is concluded that the monocytes of the terminal crisis in our case belonged to the leukemic cell strain and that these monocytes developed from non-specific promyelocytes like granulocytes. Our observation does not provide evidence for the existence of a separate monoblast which would implicate disparity of granulocytopoiesis and monocytopoiesis already at the level of undifferentiated blast cells. This, in turn, would be equal to a re-introduction of a modified polyphyletic theory of white blood cell formation.

Adult↗
PubMed1979

Isolation of highly purified sex hormone binding globulin (SHBG): evidence for microheterogeneity.

Highly purified sex hormone binding globulin (SHBG) was isolated in milligram amounts from a human serum fraction (Cohn IV-4). The final preparation was homogeneous by the criteria of polyacrylamide-gel electrophoresis. Immunological evidence for purity could be given by double diffusion according to Ouchterlony. However, following gel isoelectric focusing highly purified SHBG displayed four different bands, as could be demonstrated by staining as well as by a photoscan of the [3H]5alpha-dihydrotestosterone-SHBG complex. After incubation with neuraminidase the microheterogeneity of SHBG disappeared and the asialo-SHBG showed only one band.

Chromatography, Gel↗
PubMed1978

[The value of ultra-sound examinations for tumours and hyperplasia of the adrenals (author's transl)].

The results of ultrasound examination of the adrenals in 76 patients are described. In ten patients, tumours were found and in five there was bilateral hyperplasia of the adrenals due to Cushing's syndrome; these were confirmed at operation or by autopsy or angiography. Two false positive and two false negative findings were corrected at operation. In 57 patients negative findings were confirmed by the subsequent clinical course. An accuracy of 88% in positive and 97% in negative findings is related to the composition of the clinical material and the size of the tumours. The value of sonography is compared with other methods of localisation.

Adrenal Gland Neoplasms↗