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W Muhammad

Publications and source records attributed to W Muhammad.

8 recordsLinked to original sources
PubMed2004

Averaging signals with random time shift and time scale fluctuations.

OBJECTIVES: Our main objective was to propose an alternative to the technique of signal averaging (SA) to avoid shape distortions due to jittering and scale fluctuations, leading to a mean shape signal rather than to an average one. METHODS: In case of both time shift and time scale fluctuations of the individual signals, the first point was to show what model makes it possible to interpret their expected action as a linear shift invariant filter followed by a scale invariant one. So, even in the case of equal shape signals, the average is clearly not the same shape. The second point was to propose another averaging process, using the normalized integrals and called Shape Averaging (ShA) which provides, in this case, a mean signal preserving the common shape. RESULTS: The performances of ShA were firstly shown by simulation. Shifted and scaled versions of a given signal, without and with additive noise, have been generated at random. The mean shape signal obtained by ShA was compared to the shifted and scaled signal using the exact average values of the shifts and scale factors. A very good reconstruction of the mean shape signal is obtained for SNR = 20 dB and quite good for 8 dB, especially compared to SA. The method was then applied to a series of M-waves coming from surface EMG signals. In this case, the comparison of ShA with SA makes it possible to appreciate the validity of equal shape signal hypothesis.

Algorithms↗
PubMed2004

Prescription and dispensing practices in public sector health facilities in Pakistan: survey report.

OBJECTIVES: To gather information on existing prescription practices, dispensing practices and patient satisfaction in government health services of the NWFP, Baluchistan and Punjab province. METHODS: A cross sectional study design was used for this purpose. Ten health care facilities were selected from each province keeping appropriate representation from first level health facilities, district health facilities and tertiary care hospital. Analysis of selected indicators was carried out on the basis of provinces, health facilities, gender and different age groups. RESULTS: Documentation of 914 responses was completed from three provinces. Almost equal distribution of encounters was maintained representing different health facilities. Forty seven percent of encounters involved children under 15 years of age. Female patients comprised of 56% and the mean age of the entire sample was 26 years. The mean dispensing time was only 38 seconds, the mean consultation time was 1.79 minutes and the average number of drugs per prescription turned out to be 2.7 out of which only 1.6 drugs were being dispensed from the facility. More than half of the prescriptions contained antibiotics and 15% of patients were prescribed with injectables. Only half of the patients expressed satisfaction with their visit to health facility. CONCLUSIONS: Like many other developing countries, prescription and dispensing practices are not satisfactory in public sector health facilities of Pakistan. Appropriate and workable solutions need to be developed and implemented in the country to improve systems. Regular audits and qualitative studies should become part of the effort.

Adolescent↗
PubMed2001

Genotyping single nucleotide polymorphisms using intact polymerase chain reaction products by electrospray quadrupole mass spectrometry.

Both single nucleotide polymorphisms (SNPs) and mutations are commonly observed in the gene encoding the tumor suppressor protein, p53. SNPs occur at specific locations within genes whereas mutations may be distributed across large regions of genes. When determining nucleotide differences, mass spectrometry is the only method other than Sanger sequencing which offers direct structural information. Electrospray ionization (ESI) quadrupole mass spectrometry (MS) analysis of intact polymerase chain reaction (PCR) products was performed following a simple purification and on-line heating to limit ion adduction. The PCR products were amplified directly from genomic DNA rather than plasmids, as in our previous work. Two known polymorphisms of the p53 gene were genotyped. A cytosine (C) or guanine (G) transversion, designated C <--> G (G <--> C on the opposite strand), were each detected by a 40.0 Da change upon ESI quadrupole MS analysis. Using known PCR products as standards, the genotypes determined for 10 human samples corresponded with restriction fragment length polymorphism (RFLP) analysis. Cytosine/thymine (T) transitions, designated C <--> T (G <--> A on the opposite strand), were also genotyped by ESI-MS. This SNP is discriminated by a 15.0 Da change on one strand (C <--> T) and a 16.0 Da change on the other (G <--> A). Appropriate sample preparation and instrumental configuration (including heated sample inlet syringe and MS source), to limit adducts, are both vital for successful ESI quadrupole MS analysis of intact PCR products.

DNA↗
PubMed2001

Estimation of single motor unit conduction velocity from surface electromyogram signals detected with linear electrode arrays.

This work addresses the problem of estimating the conduction velocity (CV) of single motor unit (MU) action potentials from surface EMG signals detected with linear electrode arrays during voluntary muscle contractions. In ideal conditions, that is without shape or scale changes of the propagating signals and with additive white Gaussian noise, the maximum likelihood (ML) is the optimum estimator of delay. Nevertheless, other methods with computational advantages can be proposed; among them, a modified version of the beamforming algorithm is presented and compared with the ML estimator. In real cases, the resolution in delay estimation in the time domain is limited because of the sampling process. Transformation to the frequency domain allows a continuous estimation. A fast, high-resolution implementation of the presented multichannel techniques in the frequency domain is proposed. This approach is affected by a negligible decrease in performance with respect to ideal interpolation. Application of the ML estimator, based on two-channel information, to ten firings of each of three MUs provides a CV estimate affected by a standard deviation of 0.5 m s(-1); the modified beamforming and ML estimators based on five channels provide a CV standard deviation of less than 0.1 m s(-1) and allow the detection of statistically significant differences between the CVs of the three MUs. CV can therefore be used for MU classification.

Action Potentials↗
PubMed2000

P300, N400, aerobic fitness, and maximal aerobic exercise.

Electrophysiological effects of aerobic fitness and maximal aerobic exercise were investigated by comparing P300 and N400 before and after a maximal cycling test. Event-related potentials (ERPs) were obtained from 20 students divided into two matched groups defined by their aerobic fitness level (cyclists vs. sedentary subjects). The session of postexercise ERPs was performed immediately after body temperature and heart rate returned to preexercise values. At rest, no significant differences were observed in ERP parameters between cyclists and sedentary subjects. This finding argued against the hypothesis that ERP modifications may be directly assumed by aerobic fitness level. The postexercise session of ERPs showed a significant P300 amplitude increase and a significant P300 latency decrease in all subjects. Similarly, N400 effect increased significantly after the maximal exercise in all subjects. ERP changes were of the same magnitude in the two groups. The present study argues for a general arousing effect of maximal aerobic exercise, independently of the aerobic fitness level.

Adolescent↗
PubMed2000

Estimation of scale factors in presence of multiple signals: application to sEMG analysis.

When several realizations of an unknown recurrent signal are observed apart from a time expansion or compression, the classical way of estimating these time scaling factors is to take one signal as reference for the estimation. This approach does not take into account the common information between all possible couples of realizations. To achieve this task we use a Maximum-Likelihood based method, in a sub-optimal manner. Using some realistic assumptions and simplifications, we propose a tractable solution. The improvement of classical results is shown through a simulation whose conclusion is that the larger the number of realizations, the more correct the estimation. Finally, we apply the method to electrically evoked sEMG.

Computer Simulation↗
PubMed1987

Chorio angioma.

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Adult↗