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W N FISHBEIN

Publications and source records attributed to W N FISHBEIN.

8 recordsLinked to original sources

HYDROXYUREA: MECHANISM OF ACTION.

Acetohydroxamic acid has been identified, by paper chromatography, in the blood of three patients with chronic myelogenous leukemia on hydroxyurea therapy. This suggests that the drug is hydrolyzed yielding hyroxylamine, which then cleaves thioesters, in particular acetyl-coenzyme A.

Blood Chemical Analysis↗