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W Niederer

Publications and source records attributed to W Niederer.

At least 37 records · Page 2Linked to original sources

[Trabeculectomy: surgical technique, results, indications (author's transl)].

In this teaching-course special emphasis is given on surgical techniques and postoperative care of trabeculectomy. The follow-up of 114 eyes of 103 patients is reported. High tension in the early postoperative phase allowed no prediction of the later results. After 3 months 11%, and after one year 39% of the operated eyes with simple glaucoma had a tension higher than 22 mm Hg, even if drugs were given. Different sites of the excision in regard to the trabecular meshwork and Schlemm's canal gave no statistically different results. The filtering blebs have the tendency to develop in two directions, either scarring or becoming cystic. The cystic filtering blebs give better functional results. The development of the filtering bleb was inversely proportional to the height of the tension but went parallel to the facility of outflow. The visual acuity diminished in 35%, mostly due to cataract-formation and improved in 3%. Different complications happened in 6%. The authors consider the trabeculectomy to be the operation of choice for almost all forms of glaucoma.

Follow-Up Studies↗

Pharmacokinetic study with synthetic salmon calcitonin (Sandoz).

18 patients randomly divided into 3 groups of six each received 35 mug (140 M.R.C. Units) of synthetic salmon calcitonin intravenously, intramuscularly or subcutaneously. Plasma and urin concentrations were determined using the radioimmunoassay method. There was a rapid distribution phase of ca. 12 minutes after intravenous injection then an elimination half-life of 1.1 hours. The volume of distribution was 11 litres. The invasion half-life after intramuscular and subcutaneous administration was 12 and 11 minutes respectively and the elimination half-lives 1 and 1.5 hours, respectively. The bioavailability of the intramuscular and subcutaneous forms was found to be 66 and 71% respectively when areas under their plasma concentration/time curves were compared with the intravenous area.

Adolescent↗