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Biomedical subjects

W Nolan

Publications and source records attributed to W Nolan.

8 recordsLinked to original sources
PubMed2002

Biometric gonioscopy and the effects of age, race, and sex on the anterior chamber angle.

AIM: To utilise a novel method for making measurements in the anterior chamber in order to compare the anterior chamber angles of people of European, African, and east Asian descent aged 40 years and over. METHODS: A cross sectional study on 15 people of each sex from each decade from the 40s to the 70s, from each of three racial groups-black, white, and Chinese Singaporeans. Biometric gonioscopy (BG) utilises a slit lamp mounted reticule to make measurements from the apparent iris insertion to Schwalbe's line through a Goldmann one mirror goniolens. The main outcome measures were BG measurements of the anterior chamber angle as detailed above. RESULTS: There was no significant difference in angle measurement between black, white, and Chinese races in this study. However, at younger ages people of Chinese race appeared to have deeper angles than white or black people, whereas the angles of older Chinese were significantly narrower (p = 0.004 for the difference in slope of BG by age between Chinese and both black and white people). CONCLUSION: The failure to detect a difference in angle measurements between these groups was surprising, given the much higher prevalence of angle closure among Chinese. It appears that the overall apparent similarity of BG means between Chinese and Western populations may mask very different trends with age. The apparently more rapid decline in angle width measurements with age among Chinese may be due to the higher prevalence of cataract or "creeping angle closure." However, longitudinal inferences from cross sectional data are problematic, and this may represent a cohort phenomenon caused by the increasing prevalence of myopia in the younger Singaporean population.

Adult↗
PubMed1996

A nurse practitioner-led, collaborative, outpatient practice: a case study in outcomes management.

To survive, a nurse practitioner-led primary care service must demonstrate that clinical care, patient satisfaction, and financial results are better than those of the competition. Nurse managers must develop a customer-oriented outcomes-management system to ensure the viability of the practice, especially in today's managed care environment. The authors describe how one nurse practitioner-led practice confronted these challenges to establish a successful business and provide opportunities for teaching and research.

Community Health Centers↗
PubMed1980

Arterial PaCO2 during chronic hyperthermia in sheep.

This study was undertaken to determine if the decrease in PaCO2 and the concomitant increase in pHa seen during acute (less than 24 h) hyperthermia in all mammals was modified when the hyperthermia was maintained for periods longer than 1 day. Catheters were placed in the descending aortas of anesthetized ewes (pentobarbital, 30 mg/kg, i.v.). After recovery from the surgery, arterial blood samples were drawn daily during a 7 day control period and an 8 day period of continuous hyperthermia. In all animals PaCO2 decreased and remained low during the entire hyperthermic period. PaCO2 (torr) and Tr (degrees C) were inversely correlated by the equation: PaCO2 = - 6.08 Tr + 267.8 (r = 0.84). There was an initial alkalosis with hyperthermia, however pH tended to decrease after the fifth day of hyperthermia. Calculated bicarbonate decreased during hyperthermia. The evidence suggested that when body temperature was increased in sheep, PaCO2 was maintained at a lower value. The low PaCO2 value was maintained independent of changes in pHa.

Acid-Base Equilibrium↗